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TRPM4-IN-1

Cat. No. M11223
TRPM4-IN-1 Structure
Synonym:

CBA, Compound 5, TRPM4 inhibitor 5

Size Price Availability Quantity
10mg USD 100  USD100 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Trpm4-in-1 (CBA) is an effective and selective cationic channel TRPM4 inhibitor with an IC50 of 1.5 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 340.16
Formula C15H11Cl2NO4
CAS Number 351424-20-9
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
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  Catalog
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Keywords: TRPM4-IN-1, CBA, Compound 5, TRPM4 inhibitor 5 supplier, TRP Channel, inhibitors

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