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TRPM4-IN-1

Cat. No. M11223
TRPM4-IN-1 Structure
Synonym:

CBA, Compound 5, TRPM4 inhibitor 5

Size Price Availability Quantity
10mg USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Trpm4-in-1 (CBA) is an effective and selective cationic channel TRPM4 inhibitor with an IC50 of 1.5 μM.

Chemical Information
Molecular Weight 340.16
Formula C15H11Cl2NO4
CAS Number 351424-20-9
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: TRPM4-IN-1, CBA, Compound 5, TRPM4 inhibitor 5 supplier, TRP Channel, inhibitors, activators

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