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Icilin

Cat. No. M2591
Icilin Structure
Synonym:

AG 3-5

Size Price Availability Quantity
10mM*1mL in DMSO USD 40  USD40 In stock
10mg USD 65  USD65 In stock
50mg USD 230  USD230 In stock
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Quality Control & Documentation
Biological Activity

Icilin is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel.icilin, a super-cooling agent, down-regulated the expression of cell cycle signature genes and caused G1 arrest in PC-3 prostate cancer cells. Icilin Induces currents in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) more potently than menthol or low temperatures. icilin affected cell cycle-related transcriptional modules and identified E2F1 transcription factor as a target master regulator of icilin. icilin reduced the activity and expression levels of E2F1.

Chemical Information
Molecular Weight 311.29
Formula C16H13N3O4
CAS Number 36945-98-9
Solubility (25°C) DMSO 15 mg/ml
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lee S,et al. Biochem Biophys Res Commun. Icilin inhibits E2F1-mediated cell cycle regulatory programs in prostate cancer.

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