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Probenecid

Cat. No. M2960
Probenecid  Structure
Synonym:

Benemid

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 50  USD50 In stock
500mg USD 40  USD40 In stock
1g USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

Probenecid is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16.

Product Citations
Chemical Information
Molecular Weight 285.36
Formula C13H19NO4S
CAS Number 57-66-9
Solubility (25°C) DMSO 47 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Richard J Everts, et al. Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers

[2] Richard J Everts, et al. Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers

[3] Ana Laura Coln-Gonzlez, et al. Probenecid: an emerging tool for neuroprotection

[4] Nathan Robbins, et al. The history and future of probenecid

[5] G R Brown. Cephalosporin-probenecid drug interactions

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Keywords: Probenecid , Benemid supplier, TRP Channel, inhibitors, activators

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