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Probenecid

Cat. No. M2960
Probenecid  Structure
Synonym:

Benemid

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 50  USD50 In stock
500mg USD 40  USD40 In stock
1g USD 55  USD55 In stock
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Quality Control
Biological Activity

Probenecid is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 285.36
Formula C13H19NO4S
CAS Number 57-66-9
Purity 99.56%
Solubility DMSO 47 mg/mL
Storage at -20°C
References

[1] Richard J Everts, et al. Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers

[2] Richard J Everts, et al. Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers

[3] Ana Laura Coln-Gonzlez, et al. Probenecid: an emerging tool for neuroprotection

[4] Nathan Robbins, et al. The history and future of probenecid

[5] G R Brown. Cephalosporin-probenecid drug interactions

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Probenecid , Benemid supplier, TRP Channel, inhibitors

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