About 2 results found for searched term "Icilin" (0.132 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2591 | Icilin | TRP Channel |
| AG 3-5 | ||
| Icilin is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel. | ||
| M30211 | Voacangine | TRP Channel |
| Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC50=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC50=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC50=9 μM) and it shows noncompetitive inhibition against icilin (IC50=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana. | ||
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