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SKF 96365 hydrochloride

Cat. No. M7303
SKF 96365 hydrochloride Structure
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

SKF 96365 hydrochloride is a store-operated Ca2+ entry (SOCE) inhibitor that inhibits STIM1. Also blocks TRPC channels, voltage-gated Ca2+ channels and potassium channels.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 402.92
Formula C22H26N2O3.HCl
CAS Number 130495-35-1
Purity >99%
Solubility Water 60 mg/mL
DMSO 60 mg/mL
Storage at -20°C
References

[1] Gierse, et al. Biochem J. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase.

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