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JT010

Cat. No. M8608
JT010 Structure
Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 160  USD160 In stock
25mg USD 310  USD310 In stock
50mg USD 500  USD500 In stock
100mg USD 800  USD800 In stock
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Quality Control & Documentation
Biological Activity

JT010 is a potent agonist of TRPA1 with an EC50 of 0.65 nM. JT0101 stimulates calcium influx in TRPA1-transfected HEK293 cells in a dose-dependent manner (EC50 = 650 pM) with excellent selectivity over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 >1 μM).

Chemical Information
Molecular Weight 354.85
Formula C16H19ClN2O3S
CAS Number 917562-33-5
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Clara Hoebart, et al. No functional TRPA1 in cardiomyocytes

[2] Kento Tazawa, et al. Transient Receptor Potential Ankyrin 1 Is Up-Regulated in Response to Lipopolysaccharide via P38/Mitogen-Activated Protein Kinase in Dental Pulp Cells and Promotes Mineralization

[3] Yang Suo, et al. Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel

[4] Stefan Heber, et al. A Human TRPA1-Specific Pain Model

[5] Junichiro Takaya, et al. A Potent and Site-Selective Agonist of TRPA1

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