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TRP Channel Transient Receptor Potential Channel

Cat.No.  Name Information
M6494 BCTC BCTC is a tRPV1 antagonist. BCTC is also a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells.
M3422 Capsaicin Capsaicin is an active component of chili peppers, which are plants belonging to the genus Capsicum.
M7698 Capsazepine Capsazepine is a specific vanilloid receptor antagonist; synthetic analog of capsaicin.
M10315 MK6-83 MK6-83 is an agonist of the transient receptor potential channel ML3 (TRPML3).
M9962 Nonivamide Nonivamide (also called pelargonic acid vanillylamide or PAVA) can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.
M2960 Probenecid Probenecid is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16.
M7816 GSK1016790A GSK1016790A is a novel and potent TRPV4 channel agonist.
M1846 SB-705498 SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1.
M7264 SB 366791 SB 366791 is a potent, selective, competitive TRPV1 antagonist.
M14285 Pyr10 Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor.
M14284 Pico145 Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (−)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8.
M14283 PF-4840154 PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively. PF-4840154 elicits TrpA1-mediated nocifensive behaviour in mouse.
M14279 GSK205 GSK205 is a potent, selective TRPV4 antagonist with an IC50 of 4.19  μM for inhibiting TRPV4-mediated Ca2+ influx.
M14277 BI-749327 BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively.
M11223 TRPM4-IN-1 Trpm4-in-1 (CBA) is an effective and selective cationic channel TRPM4 inhibitor with an IC50 of 1.5 μM.
M10927 GFB-8438 GFB-8438 is a potent subtype selective TRPC5 inhibitor against hTRPC5 and hTRPC4 IC50 0.18 and 0.29 μM, respectively. GFB-8438 has good selectivity for TRPC6, other members of the TRP family, NaV1.5, and limited activity against hERG channels. Protective effect of GFB-8438 on mouse podocytes.
M10841 Mavatrep Mavatrep is an orally active TRPV1 antagonist with high affinity for the hTRPV1 channel, inhibits the binding of the TRPV1 agonist to [3H]-Resiniferatoxin (Ki=6.5 nM), and has a low effect on the enzymatic activity of CYP subtypes 3A4, 1A2, and 2D6.
M10840 JNJ-17203212 JNJ-17203212 is a selective, highly effective, competitive TRPV1 antagonist. JNJ-17203212 was developed for research on pain management, such as migraines.
M10625 GSK2193874 GSK2193874 is a first-in-class orally bioavailable potent antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist with IC50 values of 2, 5, and 40 nM. GSK2193874 is the first-in-class orally bioavailable TRPV4 inhibitor that demonstrated ability to improve pulmonary functions in a number of heart failure models.
M10588 Methyl syringate Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.
M10535 Probenecid sodium Probenecid sodium is a sodium salt of Probenecid that is soluble in water. Probenecid (Benemid) is an organic anionic transport competitive inhibitor, as well as an agonist of transient receptor potential vanillin receptor subfamily 2(TRPV2) and an inhibitor of human bitter taste receptor TAS2R16.
M10493 MDR-652 MDR-652 is a potent and specific transient receptor potential vanilloid 1 (TRPV1) agonist with Ki of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1, respectively.
M10318 AC1903 AC1903 is a specific inhibitor of TRPC5 channel.
M8608 JT010 JT010 is a potent agonist of TRPA1 with an EC50 of 0.65 nM.
M8239 HC-067047 HC-067047 is a potent, selective inhibitor of hTRPV4.
M7975 Olvanil Vanilloid receptor agonist.
M7836 Hyperforin Hyperforin is a transient receptor typical 6 (TRPC6) channel activator that regulates Ca2+ levels by activating Ca2+-transducing non-selective typical TRPC6 channels, with antidepressant and antitumor activities. In addition, Hyperforin modulates IL-17α secretion from γδ T cells and ameliorates Imiquimod-induced skin inflammation in psoriasis-like mice.
M7387 TCS 5861528 TCS 5861528 (Chembridge-5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively.
M7375 TC-I 2000 TC-I 2000 is a tRPM8 blocker.

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