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4-(Phenylazo)benzoic acid

Cat. No. M22526
4-(Phenylazo)benzoic acid Structure
Synonym:

4-(Phenyldiazenyl)benzoic acid

Size Price Availability Quantity
500mg USD 35  USD35 In stock
1g USD 48  USD48 In stock
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Quality Control & Documentation
Biological Activity

4-(Phenyldiazenyl)benzoic acid is a photosensitive and photoswitchable TRPA1 agonist that can be used for the research of pain signaling.

Chemical Information
Molecular Weight 226.23
Formula C13H10N2O2
CAS Number 1562-93-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jing Zhang, et al. ACS Macro Lett. Thermo-, pH-, and Light-Responsive Supramolecular Complexes Based on a Thermoresponsive Hyperbranched Polymer

[2] Marco Deiana, et al. Sci Rep. Photochromic switching of the DNA helicity induced by azobenzene derivatives

[3] Bin Wang, et al. Chem Asian J. Three-Component Supramolecular System with Multistimuli-Responsive Properties in Water

[4] Xiaoyan Zhang, et al. Chemistry. A photoresponsive wettability switch based on a dimethylamino calix[4]arene

[5] Zhen-Qiang Dong, et al. Langmuir. Photoreversible polymer-surfactant micelles using the molecular recognition of α-cyclodextrin

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Keywords: 4-(Phenylazo)benzoic acid, 4-(Phenyldiazenyl)benzoic acid supplier, TRP Channel, inhibitors, activators


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