Free shipping on all orders over $ 500

4-(Phenylazo)benzoic acid

Cat. No. M22526
4-(Phenylazo)benzoic acid Structure
Synonym:

4-(Phenyldiazenyl)benzoic acid

Size Price Availability Quantity
500mg USD 35  USD35 In stock
1g USD 48  USD48 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

4-(Phenyldiazenyl)benzoic acid is a photosensitive and photoswitchable TRPA1 agonist that can be used for the research of pain signaling.

Chemical Information
Molecular Weight 226.23
Formula C13H10N2O2
CAS Number 1562-93-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jing Zhang, et al. ACS Macro Lett. Thermo-, pH-, and Light-Responsive Supramolecular Complexes Based on a Thermoresponsive Hyperbranched Polymer

[2] Marco Deiana, et al. Sci Rep. Photochromic switching of the DNA helicity induced by azobenzene derivatives

[3] Bin Wang, et al. Chem Asian J. Three-Component Supramolecular System with Multistimuli-Responsive Properties in Water

[4] Xiaoyan Zhang, et al. Chemistry. A photoresponsive wettability switch based on a dimethylamino calix[4]arene

[5] Zhen-Qiang Dong, et al. Langmuir. Photoreversible polymer-surfactant micelles using the molecular recognition of α-cyclodextrin

Related TRP Channel Products
GDC-6599

GDC-6599 is a first-in-class, orally effective TRPA1 inhibitor for studies related to chronic cough and asthma.

Acetaldehyde

Acetaldehyde is a TRP anchor protein 1 (TRPA1) agonist that is converted to non-toxic acetic acid by acetaldehyde dehydrogenase (ALDH).

Adenosine 5′-diphosphoribose sodium

Adenosine 5′-diphosphoribose sodium is a metabolite of nicotinamide adenine nucleotides (NAD+), as well as a potent intracellular Ca2+-permeable cation TRPM2 channel activator, and enhances autophagy.

JNJ-28583113

JNJ-28583113 is a brain-permeable TRPM2 antagonist and blocks phosphorylation of GSK3α and β subunits by inhibiting TRPM2. In addition, JNJ-28583113 inhibits cytokine release from microglia in response to pro-inflammatory stimuli. It has the function of protecting cells from oxidative stress-induced cell death.

L-R4W2 TFA 

L-R4W2 TFA is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC50 of 0.1 μM. L-R4W2 TFA may act as a potent analgesic.

  Catalog
Abmole Inhibitor Catalog




Keywords: 4-(Phenylazo)benzoic acid, 4-(Phenyldiazenyl)benzoic acid supplier, TRP Channel, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.