WS-12 is a potent TRPM8 agonist with an EC50 of 39 nM.
| Molecular Weight | 289.41 |
| Formula | C18H27NO2 |
| CAS Number | 68489-09-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 58 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related TRP Channel Products |
|---|
| beta-Eudesmol
Beta-Eudesmol is a natural oxygenated sesquiterpene, activates hTRPA1, with an EC50 of 32.5 μM. Beta-Eudesmol increases appetite through TRPA1. |
| GFB-887
GFB-887 is an inhibitor of transient receptor potential channels 4 and 5 (TRPC4/5) and can be used in studies related to anxiety disorders. |
| Tivanisiran
Tivanisiran is an siRNA that silences TRPV1 mRNA and can be used in studies related to dry eye. |
| MK-2295
MK-2295 (NGD-8243) is a TRPV1 antagonist. |
| KM-001
KM-001 is a potent and selective TRPV3 antagonist. |
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