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Cat. No. M20815
WS-12 Structure

Acoltremon; AR-15512; AVX-012

Size Price Availability Quantity
5mg USD 99  USD99 In stock
10mg USD 127  USD127 In stock
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Quality Control & Documentation
Biological Activity

WS-12 is a potent TRPM8 agonist with an EC50 of 39 nM.

Chemical Information
Molecular Weight 289.41
Formula C18H27NO2
CAS Number 68489-09-8
Form Solid
Solubility (25°C) DMSO 58 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Guangyu Wang. Chirality. Ligand-stereoselective allosteric activation of cold-sensing TRPM8 channels by an H-bonded homochiral menthol dimer with head-to-head or head-to-tail

[2] Ying Yin, et al. Science. Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel

[3] Michael L Thomas, et al. Assessment. Development of a 12-Item Abbreviated Three-Dimensional Wisdom Scale (3D-WS-12): Item Selection and Psychometric Properties

[4] Sherkheli Ma, et al. Pak J Pharm Sci. Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels

[5] J Shane Hooper, et al. J Appl Physiol (1985). Irritant-evoked reflex tachyarrhythmia in spontaneously hypertensive rats is reduced by inhalation of TRPM8 agonists l-menthol and WS-12

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Keywords: WS-12, Acoltremon; AR-15512; AVX-012 supplier, TRP Channel, inhibitors, activators

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