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Pico145

Cat. No. M14284

All AbMole products are for research use only, cannot be used for human consumption.

Pico145 Structure
Synonym:

HC-608; Zerencotrep

Size Price Availability Quantity
5mg USD 195  USD195 In stock
10mg USD 280  USD280 In stock
25mg USD 480  USD480 In stock
50mg USD 680  USD680 In stock
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Quality Control & Documentation
Biological Activity

Pico145 (HC-608; Zerencotrep) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (−)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8.

Chemical Information
Molecular Weight 524.88
CAS Number 1628287-16-0
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ningyong Xu, et al. Impact of Na+ permeation on collective migration of pulmonary arterial endothelial cells

[2] David J Wright, et al. Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site

[3] Aisling Minard, et al. Potent, selective, and subunit-dependent activation of TRPC5 channels by a xanthine derivative

[4] Katsuhiko Muraki, et al. Na + entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells

[5] Hussein N Rubaiy, et al. Pico145 - powerful new tool for TRPC1/4/5 channels

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Keywords: Pico145, HC-608; Zerencotrep supplier, TRP Channel, inhibitors, activators

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