Free shipping on all orders over $ 500


Cat. No. M6494
BCTC Structure
Size Price Availability Quantity
5mg USD 72  USD80 In stock
10mg USD 108  USD120 In stock
50mg USD 360  USD400 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

BCTC is a orally effective vanilloid receptor 1 (TRPV1 receptor) antagonist. BCTC is also a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. BCTC inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC50 values are 6.0 and 35 nM respectively). BCTC displays analgesic properties in rat models of inflammatory and neuropathic pain.

Cell Experiment
Cell lines
Preparation method
Incubation time
Animal Experiment
Animal models Jugular-cannulated male Sprague-Dawley rats (200-300 g)
Formulation using 25% hydroxypropyl-β-cyclodextrin as vehicle
Dosages 3, 10, and 40 mg/kg p.o. or 3 mg/kg i.v.
Administration p.o. or i.v.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 372.89
Formula C20H25ClN4O
CAS Number 393514-24-4
Purity 99.96%
Solubility DMSO ≥ 38 mg/mL
Storage at -20°C

Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells
Tao Liu, et al. Oncol Lett. 2016 Jan;11(1):182-188. PMID: 26870186.

N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties
Kenneth J Valenzano, et al. J Pharmacol Exp Ther. 2003 Jul;306(1):377-86. PMID: 12721338.

Activity of cytisine and its brominated isoteres on recombinant human α7, α4β2 and α4β4 nicotinic acetylcholine receptors.
Houlihan, et al. J Neurochem. 2001;78: 1029. PMID: 11553677.

Related TRP Channel Products

MDR-652 is a potent and specific transient receptor potential vanilloid 1 (TRPV1) agonist with Ki of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1, respectively.


AC1903 is a specific inhibitor of TRPC5 channel.


MK6-83 is an agonist of the transient receptor potential channel ML3 (TRPML3).


Nonivamide (also called pelargonic acid vanillylamide or PAVA) can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.


HC-067047 is a potent, selective inhibitor of hTRPV4.

Abmole Inhibitor Catalog 2017

Keywords: BCTC supplier, TRP Channel, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.