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Cat. No. M10318
AC1903 Structure


Size Price Availability Quantity
10mg USD 91.8  USD102 In stock
25mg USD 198  USD220 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

AC1903 is a specific inhibitor of TRPC5 channel. AC1903 does no effects on TRPC4 or TRPC6 currents and shows no off-target effects in kinase profiling assays. AC1903 (30 µM) inhibits angiotensin II-induced production of reactive oxygen species (ROS) in wild-type podocytes and podocytes expressing a mutant angiotensin II type 1 (AT1) receptor that cannot be inactivated and endocytosed. 

AC1903 specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats. Chronic administration of AC1903 suppressed severe proteinuria and prevented podocyte loss in a transgenic rat model of FSGS. AC1903 also provided therapeutic benefit in a rat model of hypertensive proteinuric kidney disease.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 303.36
Formula C19H17N3O
CAS Number 831234-13-0
Purity >98.5%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C

Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903
Swagat H Sharma, et al. Bioorg Med Chem Lett. 2019 Jan 15;29(2):155-159. PMID: 30538066.

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models
Yiming Zhou, et al. Science. 2017 Dec 8;358(6368):1332-1336. PMID: 29217578.

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Abmole Inhibitor Catalog 2017

Keywords: AC1903, AC-1903 supplier, TRP Channel, inhibitors

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