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Cat. No. M7975
Olvanil Structure
Size Price Availability Quantity
5mg USD 225  USD225 In stock
10mg USD 380  USD380 In stock
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Quality Control & Documentation
Biological Activity

Vanilloid receptor agonist

Chemical Information
Molecular Weight 417.62
Formula C26H43NO3
CAS Number 58493-49-5
Solubility (25°C) Water: <0.2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Nuray Erin, et al. Olvanil activates sensory nerve fibers, increases T cell response and decreases metastasis of breast carcinoma

[2] Tania Diaz-Vidal, et al. Cross-linked enzyme aggregates of recombinant Candida antarctica lipase B for the efficient synthesis of olvanil, a nonpungent capsaicin analogue

[3] Piotr Tutka, et al. Arvanil, olvanil, AM 1172 and LY 2183240 (various cannabinoid CB1 receptor agonists) increase the threshold for maximal electroshock-induced seizures in mice

[4] Mohammad Alsalem, et al. Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat

[5] Kit-Man Chu, et al. Olvanil: a non-pungent TRPV1 activator has anti-emetic properties in the ferret

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