Penicillin G Sodium

Biological Activity

Penicillin G Sodium is a β-lactam antibiotic produced by Penicillin spp.

Product Citations

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  J Med Chem. 2023 Dec;17138–17154.

  All-Hydrocarbon Stapled Peptide Multifunctional Agonists at Opioid and Neuropeptide FF Receptors: Highly Potent, Long-Lasting Brain Permeant Analgesics with Diminished Side Effects
  Penicillin G Sodium purchased from AbMole

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  Lipids Health Dis. 2021 Apr 26;20(1):40.

  Elucidation of SIRT-1/PGC-1α-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease
  Penicillin G Sodium purchased from AbMole

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  Biomed Res Int. 2021 Mar 23;2021:5542545.

  Sirt-1 Regulates Physiological Process and Exerts Protective Effects against Oxidative Stress
  Penicillin G Sodium purchased from AbMole

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  Sci Adv. 2020 Jul 10;6(28):eaba7260.

  A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control
  Penicillin G Sodium purchased from AbMole

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  J Exp Clin Cancer Res. 2020 May 24;39(1):93.

  TFEB-NF-κB Inflammatory Signaling Axis: A Novel Therapeutic Pathway of Dihydrotanshinone I in Doxorubicin-Induced Cardiotoxicity
  Penicillin G Sodium purchased from AbMole

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  Br J Cancer. 2020 May;122(11):1673-1685.

  CSN6-TRIM21 Axis Instigates Cancer Stemness During Tumorigenesis
  Penicillin G Sodium purchased from AbMole

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  Cell Commun Signal. 2020 Feb 17;18(1):27.

  mTOR May Interact With PARP-1 to Regulate Visible Light-Induced Parthanatos in Photoreceptors
  Penicillin G Sodium purchased from AbMole

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  Sci Rep. 2020 Jul 31;10(1):12991.

  Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis
  Penicillin G Sodium purchased from AbMole

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  Fish Shellfish Immunol. 2020 Jul;102:480-488.

  Target of rapamycin signaling inhibits autophagy in sea cucumber Apostichopus japonicus
  Penicillin G Sodium purchased from AbMole

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  Mar Drυgs. 2020 Aug 17;18(8):429.

  Comparison of Physicochemical Characteristics and Macrophage Immunostimulatory Activities of Polysaccharides from Chlamys farreri
  Penicillin G Sodium purchased from AbMole

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  J Steroid Biochem Mol Biol. 2013 Nov;138:54-62.

  Effect of androgens on different breast cancer cells co-cultured with or without breast adipose fibroblasts
  Penicillin G Sodium purchased from AbMole

Chemical Information

Molecular Weight	356.37
Formula	C16H18N2O4S.Na
CAS Number	69-57-8
Solubility (25°C)	Water 100 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nieto JE, et al. Can J Vet Res. Pharmacokinetics of a combination of amikacin sulfate and penicillin G sodium for intravenous regional limb perfusion in adult horses.

[2] Wenhui Ji, et al. FEMS Microbiol Lett. A novel endolysin disrupts Streptococcus suis with high efficiency