Penicillin G Sodium

Biological Activity

Penicillin G Sodium is a β-lactam antibiotic produced by Penicillin spp.

Product Citations

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  Lipids Health Dis. 2021 Apr 26;20(1):40.

  Elucidation of SIRT-1/PGC-1α-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease
  Penicillin G Sodium purchased from AbMole

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  Biomed Res Int. 2021 Mar 23;2021:5542545.

  Sirt-1 Regulates Physiological Process and Exerts Protective Effects against Oxidative Stress
  Penicillin G Sodium purchased from AbMole

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  Mar Drυgs. 2020 Aug 17;18(8):429.

  Comparison of Physicochemical Characteristics and Macrophage Immunostimulatory Activities of Polysaccharides from Chlamys farreri
  Penicillin G Sodium purchased from AbMole

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  Sci Rep. 2020 Jul 31;10(1):12991.

  Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis
  Penicillin G Sodium purchased from AbMole

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  Fish Shellfish Immunol. 2020 Jul;102:480-488.

  Target of rapamycin signaling inhibits autophagy in sea cucumber Apostichopus japonicus
  Penicillin G Sodium purchased from AbMole

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  J Steroid Biochem Mol Biol. 2013 Nov;138:54-62.

  Effect of androgens on different breast cancer cells co-cultured with or without breast adipose fibroblasts
  Penicillin G Sodium purchased from AbMole

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  Sci Adv. 2020 Jul 10;6(28):eaba7260.

  A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control
  Penicillin G Sodium purchased from AbMole

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  Cell Commun Signal. 2020 Feb 17;18(1):27.

  mTOR May Interact With PARP-1 to Regulate Visible Light-Induced Parthanatos in Photoreceptors
  Penicillin G Sodium purchased from AbMole

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  J Exp Clin Cancer Res. 2020 May 24;39(1):93.

  TFEB-NF-κB Inflammatory Signaling Axis: A Novel Therapeutic Pathway of Dihydrotanshinone I in Doxorubicin-Induced Cardiotoxicity
  Penicillin G Sodium purchased from AbMole

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  Br J Cancer. 2020 May;122(11):1673-1685.

  CSN6-TRIM21 Axis Instigates Cancer Stemness During Tumorigenesis
  Penicillin G Sodium purchased from AbMole

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information

References

[1] Nieto JE, et al. Can J Vet Res. Pharmacokinetics of a combination of amikacin sulfate and penicillin G sodium for intravenous regional limb perfusion in adult horses.

[2] Wenhui Ji, et al. FEMS Microbiol Lett. A novel endolysin disrupts Streptococcus suis with high efficiency