Carboxymethyl cellulose sodium

Biological Activity

Carboxymethyl cellulose sodium is frequently used as viscous agent, paste and barrier agent.

Product Citations

• 

  Front Pharmacol. 2021 Mar 3;12:613104.

  Deciphering the Pharmacological Mechanisms of Guizhi-Fuling Capsule on Primary Dysmenorrhea Through Network Pharmacology
  Carboxymethyl cellulose sodium purchased from AbMole

• 

  Biochem Biophys Res Commun. 2021 Sep 10;569:1-9.

  Rapid tumor recurrence in a novel murine GBM surgical model is associated with Akt/PD-L1/vimentin signaling
  Carboxymethyl cellulose sodium purchased from AbMole

• 

  J Exp Clin Cancer Res. 2020 May 24;39(1):93.

  TFEB-NF-κB Inflammatory Signaling Axis: A Novel Therapeutic Pathway of Dihydrotanshinone I in Doxorubicin-Induced Cardiotoxicity
  Carboxymethyl cellulose sodium purchased from AbMole

Chemical Information

Molecular Weight	242.16
Formula	C8H16NaO8
CAS Number	9004-32-4
Solubility (25°C)	Water ≥ 20 mg/mL
Storage	-20°C, dry, sealed

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Du XH, et al. Braz J Med Biol Res. Dexamethasone and sodium carboxymethyl cellulose prevent postoperative intraperitoneal adhesions in rats.