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Dihydrotestosterone

Cat. No. M6033
Dihydrotestosterone Structure
Synonym:

17β-Hydroxy-5α-androstan-3-one; DHT

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 36  USD40 In stock
10mg USD 36  USD40 In stock
25mg USD 72  USD80 In stock
50mg USD 126  USD140 In stock
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Quality Control
Biological Activity

Dihydrotestosterone is a hormone with powerful androgenic actions, causes the body to mature during puberty and is responsible for many of the physical characteristics associated with adult males.

Product Citations
Protocol
Cell Experiment
Cell lines Primary pig hepatocytes
Preparation method In steroid metabolism studies, hepatocytes were incubated in 10 ml of basal growth medium containing phenol red-free DMEM with 10% of charcoal treated FBS fortified with 10 µM (final concentration) of androstenone, 17β-estradiol or dihydrotestosterone.
Concentrations 10 µM
Incubation time 48 h
Animal Experiment
Animal models SOD1-G93A mutant mice with the congenic C57BL/6J background
Formulation Saline
Dosages 5 mg
Administration silastic implant
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 290.44
Formula C19H30O2
CAS Number 521-18-6
Purity 99.40%
Solubility DMSO 50 mg/mL
Storage at -20°C
References

Metabolism of androstenone, 17β-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3β-hydroxysteroid dehydrogenase in this process.
Chen G, et al. PLoS One. 2015 Jan 15;10(1):e113194. PMID: 25590624.

Design and synthesis of new dihydrotestosterone derivative with positive inotropic activity.
Lauro FV, et al. Steroids. 2015 Mar;95:39-50. PMID: 25578737.

Dihydrotestosterone ameliorates degeneration in muscle, axons and motoneurons and improves motor function in amyotrophic lateral sclerosis model mice.
Yoo YE, et al. PLoS One. 2012;7(5):e37258. PMID: 22606355.

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Keywords: Dihydrotestosterone, 17β-Hydroxy-5α-androstan-3-one; DHT supplier, Androgen Receptor, inhibitors

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