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Dihydrotestosterone

Cat. No. M6033

All AbMole products are for research use only, cannot be used for human consumption.

Dihydrotestosterone Structure
Synonym:

17β-Hydroxy-5α-androstan-3-one; DHT

Size Price Availability Quantity
10mM*1mL in DMSO USD 40  USD40 In stock
10mg USD 40  USD40 In stock
25mg USD 60  USD60 In stock
50mg USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Dihydrotestosterone is a hormone with powerful androgenic actions, causes the body to mature during puberty and is responsible for many of the physical characteristics associated with adult males. It can be used to construct animal models of polycystic ovary syndrome (PCOS).

Product Citations
Protocol (for reference only)
Cell Experiment
Cell lines Primary pig hepatocytes
Preparation method In steroid metabolism studies, hepatocytes were incubated in 10 ml of basal growth medium containing phenol red-free DMEM with 10% of charcoal treated FBS fortified with 10 µM (final concentration) of androstenone, 17β-estradiol or dihydrotestosterone.
Concentrations 10 µM
Incubation time 48 h
Animal Experiment
Animal models SOD1-G93A mutant mice with the congenic C57BL/6J background
Formulation Saline
Dosages 5 mg
Administration silastic implant
Chemical Information
Molecular Weight 290.44
Formula C19H30O2
CAS Number 521-18-6
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Chen G, et al. PLoS One. Metabolism of androstenone, 17β-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3β-hydroxysteroid dehydrogenase in this process.

[2] Lauro FV, et al. Steroids. Design and synthesis of new dihydrotestosterone derivative with positive inotropic activity.

[3] Yoo YE, et al. PLoS One. Dihydrotestosterone ameliorates degeneration in muscle, axons and motoneurons and improves motor function in amyotrophic lateral sclerosis model mice.

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Keywords: Dihydrotestosterone, 17β-Hydroxy-5α-androstan-3-one; DHT supplier, Animal Modeling, inhibitors, activators

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