EDTA

Biological Activity

EDTA is a chelating agent; sequesters di- and trivalent metal ions. EDTA can activate NOTCH1 signaling.

Product Citations

• 

  Cell Res. 2020 Feb;30(2):163-178.

  ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer
  EDTA purchased from AbMole

• 

  Sci Rep. 2021 Jun 14;11(1):12497.

  Neuroprotective effect of selumetinib on acrolein-induced neurotoxicity
  EDTA purchased from AbMole

• 

  Molecules. 2021 Apr 13;26(8):2231.

  F4/80 + Kupffer Cell-Derived Oncostatin M Sustains the Progression Phase of Liver Regeneration through Inhibition of TGF-β2 Pathway
  EDTA purchased from AbMole

• 

  Theranostics. 2020 Apr 27;10(13):5671-5686.

  SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating Snail mRNA homeostasis in hepatocellular carcinoma
  EDTA purchased from AbMole

Chemical Information

Molecular Weight	292.24
Formula	C10H16N2O8
CAS Number	60-00-4
Solubility (25°C)	Soluble in NaOH
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] F Pozzo, et al. Leukemia. NOTCH1-mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin 1 and ribosome-associated components

[2] Isaacson and Nicholl. Proc Natl Acad Sci USA. Aniracetam reduces glutamate receptor desensitisation and slows the decay of fast excitatory synaptic currents in the hippocampus.