EDTA is a chelating agent; sequesters di- and trivalent metal ions. EDTA can activate NOTCH1 signaling.
Cell Res. 2020 Feb;30(2):163-178.
ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer
EDTA purchased from AbMole
Sci Rep. 2021 Jun 14;11(1):12497.
Neuroprotective effect of selumetinib on acrolein-induced neurotoxicity
EDTA purchased from AbMole
Molecules. 2021 Apr 13;26(8):2231.
F4/80 + Kupffer Cell-Derived Oncostatin M Sustains the Progression Phase of Liver Regeneration through Inhibition of TGF-β2 Pathway
EDTA purchased from AbMole
Theranostics. 2020 Apr 27;10(13):5671-5686.
SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating Snail mRNA homeostasis in hepatocellular carcinoma
EDTA purchased from AbMole
Molecular Weight | 292.24 |
Formula | C10H16N2O8 |
CAS Number | 60-00-4 |
Solubility (25°C) | Soluble in NaOH |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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IMR-1A
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