EDTA is a chelating agent; sequesters di- and trivalent metal ions. EDTA can activate NOTCH1 signaling.
Sci Rep. 2021 Jun 14;11(1):12497.
Neuroprotective effect of selumetinib on acrolein-induced neurotoxicity
EDTA purchased from AbMole
Molecules. 2021 Apr 13;26(8):2231.
Theranostics. 2020 Apr 27;10(13):5671-5686.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||Soluble in NaOH|
NOTCH1-mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin 1 and ribosome-associated components
F Pozzo, et al. Leukemia. 2017 Nov;31(11):2407-2415. PMID: 28321119.
Aniracetam reduces glutamate receptor desensitisation and slows the decay of fast excitatory synaptic currents in the hippocampus.
Isaacson and Nicholl. Proc Natl Acad Sci USA. 1991;88: 10936. PMID: 1660156.
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