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EDTA

Cat. No. M6699
EDTA Structure
Size Price Availability Quantity
100g USD 36  USD40 In stock
250g USD 72  USD80 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

EDTA is a chelating agent; sequesters di- and trivalent metal ions. EDTA can activate NOTCH1 signaling.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 292.24
Formula C10H16N2O8
CAS Number 60-00-4
Purity >98%
Solubility Soluble in NaOH
Storage at -20°C
References

NOTCH1-mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin 1 and ribosome-associated components
F Pozzo, et al. Leukemia. 2017 Nov;31(11):2407-2415. PMID: 28321119.

Aniracetam reduces glutamate receptor desensitisation and slows the decay of fast excitatory synaptic currents in the hippocampus.
Isaacson and Nicholl. Proc Natl Acad Sci USA. 1991;88: 10936. PMID: 1660156.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: EDTA supplier, Notch, inhibitors

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