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EDTA is a chelating agent; sequesters di- and trivalent metal ions. EDTA can activate NOTCH1 signaling.
Sci Rep. 2021 Jun 14;11(1):12497.
Neuroprotective effect of selumetinib on acrolein-induced neurotoxicity
EDTA purchased from AbMole
Molecules. 2021 Apr 13;26(8):2231.
F4/80 + Kupffer Cell-Derived Oncostatin M Sustains the Progression Phase of Liver Regeneration through Inhibition of TGF-β2 Pathway
EDTA purchased from AbMole
Theranostics. 2020 Apr 27;10(13):5671-5686.
SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating Snail mRNA homeostasis in hepatocellular carcinoma
EDTA purchased from AbMole
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 292.24 |
| Formula | C10H16N2O8 |
| CAS Number | 60-00-4 |
| Purity | >98% |
| Solubility | Soluble in NaOH |
| Storage | at -20°C |
| Related Notch Products |
|---|
| Z-Ile-Leu-aldehyde
Z-ile-leu-aldehyde (Z-IL-Cho) is a potent and competitive peptide-aldehyde inhibitor of gamma-secretase and Notch. |
| CB-103
CB-103 is a first-in-class, orally active inhibitor of the Notch transcription activation complex. CB-103 inhibits Notch signaling in primary human T cell acute lymphoblastic leukemia and other Notch-dependent human tumor cell lines, and concomitantly induces cell cycle arrest and apoptosis. |
| NVS-ZP7-4
NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. |
| IMR-1
IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex that disrupted the recruitment of Mastermind-like 1 (Maml1) to the Notch transcriptional activation complex on chromatin. |
| BMS-906024
BMS-906024 is a γ-secretase inhibitor and pan-Notch inhibitor with antineoplastic activity. |
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