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EDTA

Cat. No. M6699
EDTA Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100g USD 40  USD40 In stock
250g USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

EDTA is a chelating agent; sequesters di- and trivalent metal ions. EDTA can activate NOTCH1 signaling.

Product Citations
Chemical Information
Molecular Weight 292.24
Formula C10H16N2O8
CAS Number 60-00-4
Solubility (25°C) Soluble in NaOH
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] F Pozzo, et al. Leukemia. NOTCH1-mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin 1 and ribosome-associated components

[2] Isaacson and Nicholl. Proc Natl Acad Sci USA. Aniracetam reduces glutamate receptor desensitisation and slows the decay of fast excitatory synaptic currents in the hippocampus.

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Keywords: EDTA supplier, Notch, inhibitors, activators


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