EDTA

Biological Activity

EDTA is a chelating agent; sequesters di- and trivalent metal ions. EDTA can activate NOTCH1 signaling.

Product Citations

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  Sci Rep. 2021 Jun 14;11(1):12497.

  Neuroprotective effect of selumetinib on acrolein-induced neurotoxicity
  EDTA purchased from AbMole

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  Molecules. 2021 Apr 13;26(8):2231.

  F4/80 + Kupffer Cell-Derived Oncostatin M Sustains the Progression Phase of Liver Regeneration through Inhibition of TGF-β2 Pathway
  EDTA purchased from AbMole

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  Theranostics. 2020 Apr 27;10(13):5671-5686.

  SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating Snail mRNA homeostasis in hepatocellular carcinoma
  EDTA purchased from AbMole

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information

References

NOTCH1-mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin 1 and ribosome-associated components
F Pozzo, et al. Leukemia. 2017 Nov;31(11):2407-2415. PMID: 28321119.

Aniracetam reduces glutamate receptor desensitisation and slows the decay of fast excitatory synaptic currents in the hippocampus.
Isaacson and Nicholl. Proc Natl Acad Sci USA. 1991;88: 10936. PMID: 1660156.