About 30 results found for searched term "Notch" (0.148 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1746 | DAPT | Gamma-secretase/Beta-secretase |
| GSI-IX | ||
| DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively. DAPT inhibits the activation of Notch 1 signaling. | ||
| M14574 | Notch inhibitor 1 | Notch |
| BMS-986115 | ||
| Notch inhibitor 1 is a potent inhibitor of Notch, with IC50 values of 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively.In addition, Notch inhibitor 1 is also an inhibitor of gamma-secretase, which can be used in sclerofibrosarcoma-related studies. | ||
| M24627 | Tarextumab | Notch |
| OMP 59R5; Anti-Human NOTCH2 Recombinant Antibody | ||
| Tarextumab (OMP-59R5) is an anti-Notch2/3 fully human IgG2 monoclonal antibody. Tarextumab shows anti-tumor activity. | ||
| M24681 | Brontictuzumab | Notch |
| OMP 52M51; Anti-Human NOTCH1 Recombinant Antibody | ||
| Brontictuzumab (OMP 52M51) is a monoclonal antibody (MAb) that inhibits Notch1 signal. Brontictuzumab selectively binds the negative regulatory region of the Notch1. Brontictuzumab inhibits tumor cell proliferation. Brontictuzumab can be used in the research of leukemia and lymphoma. | ||
| M2015 | RO4929097 | Gamma-secretase/Beta-secretase |
| RO4929097 is a potent and selective inhibitor of γ-secretase and as a result is able to inhibit Notch pathway signaling. | ||
| M2703 | FLI-06 | Notch |
| FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM. | ||
| M2827 | LY3039478 | Gamma-secretase/Beta-secretase |
| Crenigacestat | ||
| LY3039478 (Crenigacestat) is a novel and orally active Notch and γ-secretase inhibitor, with an IC50 of 1 nM in most of the tumor cell lines tested. | ||
| M2828 | LY900009 | Notch |
| LY900009 is a potent, first-in-class Notch inhibitor with IC50 of 0.27 nM. | ||
| M3523 | YO-01027 | Gamma-secretase/Beta-secretase |
| Dibenzazepine; DBZ | ||
| YO-01027 (Dibenzazepine, DBZ) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch cleavage, respectively. | ||
| M3619 | Begacestat | Gamma-secretase/Beta-secretase |
| GSI-953 | ||
| Begacestat selectively inhibits cleavage of amyloid precursor protein (APP) over Notch. Lowers levels of Aβ42 and Aβ40 (EC50 values are 12.4 and 14.8 nM respectively in cells expressing human recombinant APP). | ||
| M4553 | Tangeretin | Notch |
| Tangeritin; NSC53909; NSC618905; Ponkanetin | ||
| Tangeretin is a flavonoid from citrus fruit peels, and is also selected as a Notch-1 inhibitor, which plays an important role in anti-inflammatory responses and neuroprotective effects in several disease models. | ||
| M6699 | EDTA | Notch |
| EDTA is a chelating agent. EDTA can activate NOTCH1 signaling. | ||
| M7667 | BMS-906024 | Notch |
| Osugacestat | ||
| BMS-906024 is a γ-secretase inhibitor and pan-Notch inhibitor with IC50 values of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, 2, 3, and 4 receptors, respectively. BMS-906024 has antineoplastic activity. | ||
| M8679 | IMR-1 | Notch |
| IMR-1 is a first-in-class, cell-permeable inhibitor of the Notch transcription activation complex, with an IC50 of 26 μM. IMR-1 prevents Maml1 from recruiting to the Notch ternary complex (NTC) in chromatin, inhibits transcription of Notch target genes, and has antitumor activity. | ||
| M9054 | Valproic acid | HDAC |
| Erganyl; Stavzor; VPA | ||
| Valproic acid (VPA) is an HDAC inhibitor with IC50 in the range of 0.5~2 mM. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. | ||
| M9505 | Compound E | Gamma-secretase/Beta-secretase |
| GSI-XXI; γ-secretase inhibitor XXI; γ-Secretase-IN-1 | ||
| Compound E is a cell-permeable, potent, selective inhibitor of γ-secretase and Notch processing. | ||
| M10088 | NVS-ZP7-4 | Notch |
| NVSZP74 | ||
| NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. | ||
| M10373 | CB-103 | Notch |
| CB103; Limantrafin | ||
| CB-103 is a first-in-class, orally active inhibitor of the Notch transcription activation complex. CB-103 inhibits Notch signaling in primary human T cell acute lymphoblastic leukemia and other Notch-dependent human tumor cell lines, and concomitantly induces cell cycle arrest and apoptosis. | ||
| M10798 | BMS-983970 | Notch |
| BMS-983970 is an oral Notch inhibitor with antitumor activity. | ||
| M11280 | Z-Ile-Leu-aldehyde | Notch |
| Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII | ||
| Z-ile-leu-aldehyde (Z-IL-Cho) is a potent and competitive peptide-aldehyde inhibitor of gamma-secretase and Notch. | ||
| M14569 | Bruceine D | Notch |
| Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. | ||
| M14571 | IMR-1A | Notch |
| IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A. | ||
| M14572 | Jagged-1 (188-204) TFA | Notch |
| Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells. | ||
| M14575 | RBPJ Inhibitor-1 | Notch |
| RIN1 | ||
| RBPJ Inhibitor-1 (RIN1) is a first-in-class RBPJ inhibitor that blocks the interaction between RBPJ and SHARP.RBPJ Inhibitor-1 (RIN1) inhibits the proliferation of Notch-dependent tumor cells. | ||
| M14583 | E 2012 | Gamma-secretase/Beta-secretase |
| E2012 | ||
| E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. | ||
| M24588 | Demcizumab | Notch |
| OMP 21M18 Human Anti-TNFRSF10B Recombinant Antibody | ||
| Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent inhibitor of the Notch pathway. Demcizumab alone or in combination with chemotherapy is effective in various cancer models. | ||
| M25550 | ASR-490 | Notch |
| ASR-490 reduces the viability of HCT116 and SW620 cells by downregulating Notch1 signaling. ASR-490 overcomes Notch1 overexpression and inhibits the growth of HCT/Notch1 transfectants. ASR-490 inhibits the tumor growth in control (pCMV/HCT116) and Notch1/HCT116 in xenotransplanted mice. | ||
| M29135 | SAHM1 | Notch |
| SAHM1, a peptide mimetic of a dominant negative form of mastermind-like (MAML), inhibits canonical Notch transcription complex formation. SAHM1 can be used for the research of allergic airway inflammation in mice. | ||
| M29222 | Yhhu-3792 | Notch |
| Yhhu-3792 enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) in mouse. Yhhu-3792 increases the spatial and episodic memory abilities of mice. Yhhu-3792 has the potential for the research of impairment of learning and memory associated DG dysfunction. | ||
| M29400 | JI051 | Notch |
| JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity. | ||
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