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Brontictuzumab

Cat. No. M24681
Brontictuzumab Structure
Synonym:

OMP 52M51; Anti-Human NOTCH1 Recombinant Antibody

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Biological Activity

Brontictuzumab (OMP 52M51) is a monoclonal antibody (MAb) that inhibits Notch1 signal. Brontictuzumab selectively binds the negative regulatory region of the Notch1. Brontictuzumab inhibits tumor cell proliferation. Brontictuzumab can be used in the research of leukemia and lymphoma.

Chemical Information
CAS Number 1447814-75-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dayana Herrera-Rios, et al. Sci Rep. A computational guided, functional validation of a novel therapeutic antibody proposes Notch signaling as a clinical relevant and drυggable target in glioma

[2] Mian Xie, et al. Lung Cancer. Alterations of Notch pathway in patients with adenoid cystic carcinoma of the trachea and its impact on survival

[3] R Ferrarotto, et al. Ann Oncol. A phase I dose-escalation and dose-expansion study of brontictuzumab in subjects with selected solid tumors

[4] Renata Ferrarotto, et al. J Clin Oncol. Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors

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Keywords: Brontictuzumab, OMP 52M51; Anti-Human NOTCH1 Recombinant Antibody supplier, Notch, inhibitors, activators

 
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