|M10373||CB-103||CB-103 is a first-in-class, orally active γ-secretase inhibitor, CB-103 inhibits Notch signaling in primary human T cell acute lymphoblastic leukemia and other Notch-dependent human tumor cell lines, and concomitantly induces cell cycle arrest and apoptosis.|
|M10088||NVS-ZP7-4||NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress.|
|M8679||IMR-1||IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex that disrupted the recruitment of Mastermind-like 1 (Maml1) to the Notch transcriptional activation complex on chromatin.|
|M7667||BMS-906024||BMS-906024 is a γ-secretase inhibitor and pan-Notch inhibitor with antineoplastic activity.|
|M6699||EDTA||EDTA is a chelating agent. EDTA can activate NOTCH1 signaling.|
|M4553||Tangeretin||Tangeretin is a flavonoid from citrus fruit peels, and is also selected as a Notch-1 inhibitor, which plays an important role in anti-inflammatory responses and neuroprotective effects in several disease models.|
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