| Cat.No. | Name | Information |
|---|---|---|
| M6699 | EDTA | EDTA is a chelating agent. EDTA can activate NOTCH1 signaling. |
| M24764 | Navicixizumab | Navicixizumab (OMP-305B83) is a bispecific anti-VEGF and anti-DLL4 inhibitory antibody. Navicixizumab can combine with Paclitaxel for cancer research. Navicixizumab can be used in the research of ovarian, primary peritoneal, or fallopian tube cancer. |
| M24736 | Rovalpituzumab | Rovalpituzumab is a humanized monoclonal antibody against delta-like protein 3 (DLL3). Rovalpituzumab can be used in the synthesis of antibody-drug conjugate (ADC), Rovalpituzumab Tesirine. Rovalpituzumab has activity against small cell lung cancer (SCLC). |
| M24681 | Brontictuzumab | Brontictuzumab (OMP 52M51) is a monoclonal antibody (MAb) that inhibits Notch1 signal. Brontictuzumab selectively binds the negative regulatory region of the Notch1. Brontictuzumab inhibits tumor cell proliferation. Brontictuzumab can be used in the research of leukemia and lymphoma. |
| M24627 | Tarextumab | Tarextumab (OMP-59R5) is an anti-Notch2/3 fully human IgG2 monoclonal antibody. Tarextumab shows anti-tumor activity. |
| M24588 | Demcizumab | Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent inhibitor of the Notch pathway. Demcizumab alone or in combination with chemotherapy is effective in various cancer models. |
| M14574 | Notch inhibitor 1 | Notch inhibitor 1 is a potent inhibitor of Notch, with IC50 values of 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively.In addition, Notch inhibitor 1 is also an inhibitor of gamma-secretase, which can be used in sclerofibrosarcoma-related studies. |
| M14571 | IMR-1A | IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A. |
| M14570 | Carvacrol | Carvacrol is a monoterpenoid phenol isolated from Lamiaceae family plants, with antioxidant, anti-inflammatory and anticancer properties. |
| M11280 | Z-Ile-Leu-aldehyde | Z-ile-leu-aldehyde (Z-IL-Cho) is a potent and competitive peptide-aldehyde inhibitor of gamma-secretase and Notch. |
| M7667 | BMS-906024 | BMS-906024 is a γ-secretase inhibitor and pan-Notch inhibitor with IC50 values of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, 2, 3, and 4 receptors, respectively. BMS-906024 has antineoplastic activity. |
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