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ASR-490 reduces the viability of HCT116 and SW620 cells by downregulating Notch1 signaling. ASR-490 overcomes Notch1 overexpression and inhibits the growth of HCT/Notch1 transfectants. ASR-490 inhibits the tumor growth in control (pCMV/HCT116) and Notch1/HCT116 in xenotransplanted mice.
| Molecular Weight | 575.69 |
| Formula | C34H41NO7 |
| CAS Number | 2690312-67-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage | Powder -20°C |
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