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Cat. No. M10088
NVS-ZP7-4 Structure


Size Price Availability Quantity
10mg USD 350  USD350 In stock
25mg USD 650  USD650 In stock
50mg USD 1100  USD1100 In stock
100mg USD 1700  USD1700 In stock
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Quality Control
Biological Activity

NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. NVS-ZP7-4 altered zinc in the ER, and an analog of the compound photoaffinity labeled ZIP7 in cells. NVS-ZP7-4 can probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 501.62
Formula C28H28FN5OS
CAS Number 2349367-89-9
Purity 99.92%
Solubility DMSO 100 mg/mL
Storage -20°C, protect from light, dry, sealed

[1] Erin Nolin, et al. Nat Chem Biol. Discovery of a ZIP7 inhibitor from a Notch pathway screen

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Keywords: NVS-ZP7-4, NVSZP74 supplier, Notch, inhibitors

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