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Jagged-1 (188-204) is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity.
| Molecular Weight | 2107.4 |
| Formula | C93H127N25O26S3 |
| CAS Number | 219127-21-6 |
| Solubility (25°C) | Water ≥ 10 mg/mL |
| Storage | -20°C, dry, sealed |
| Related Notch Products |
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| DAPM
DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. |
| Procyanidin B2 3,3'-di-O-gallate
Procyanidin B2, 3,3'-di-O-gallate is an active constituent. Procyanidin B2, 3,3'-di-O-gallate strongly suppresses the constitutive as well as Jagged1 (Notch1 ligand)-induced activated Notch1 pathway. |
| SAHM1 TFA
SAHM1 TFA is a Notch pathway inhibitor. SAHM1 TFA stabilizes hydrocarbon-stapled alpha helical peptide. SAHM1 TFA targets the protein-protein interface and prevents Notch complex assembly. |
| JI051
JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity. |
| Yhhu-3792
Yhhu-3792 enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) in mouse. Yhhu-3792 increases the spatial and episodic memory abilities of mice. Yhhu-3792 has the potential for the research of impairment of learning and memory associated DG dysfunction. |
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