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MPP+ iodide is a toxic metabolite of the neurotoxin MPTP, MPP+ iodide causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT). MPP+ also inhibits the activity of nicotinamide adenosine dinucleotide (NADH)-linked respiration in mitochondrial preparations and impairs aerobic glycolysis, leading to the present belief that the inhibition of NADH-linked cell respiration may constitute the final molecular mechanism of MPP+ neurotoxicity.
J Inflamm Res. 2024 May 21;17:3259-3282.
Role of Inflammation in the Development of COVID-19 to Parkinson’s Disease
MPP+ iodide purchased from AbMole
| Molecular Weight | 297.13 |
| Formula | C12H12IN |
| CAS Number | 36913-39-0 |
| Solubility (25°C) | Water 90 mg/mL DMSO 60 mg/mL |
| Storage | -20°C, dry, sealed |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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