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Disulfiram

Cat. No. M3390
Disulfiram Structure
Synonym:

Tetraethylthiuram disulfide; TETD

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 30  USD30 In stock
500mg USD 38  USD38 In stock
1g USD 50  USD50 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Disulfiram is used in the study of chronic alcoholism with acute sensitivity to alcohol and is a potent copper ion-carrier that can be used in the study of copper death.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 296.54
Formula C10H20N2S4
CAS Number 97-77-8
Purity 99.67%
Solubility DMSO 49 mg/mL
Storage at -20°C
References

[1] Di Chen, et al. Cancer Res . Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity

[2] Sukhdev S Brar, et al. Mol Cancer Ther . Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease

[3] Patrycja Kleczkowska, et al. Advantages and disadvantages of disulfiram coadministered with popular addictive substances

[4] Chen Lu, et al. Disulfiram: a novel repurposed drug for cancer therapy

[5] Elmira Ekinci, et al. Repurposing Disulfiram as An Anti-Cancer Agent: Updated Review on Literature and Patents

[6] J Mutschler, et al. Current Findings and Mechanisms of Action of Disulfiram in the Treatment of Alcohol Dependence

[7] T Widenius, et al. Disulfiram therapy

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Keywords: Disulfiram, Tetraethylthiuram disulfide; TETD supplier, Cuproptosis, inhibitors

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