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CY-09 is a selective and direct NLRP3 inhibitor to treat inflammatory disorders. CY-09 specifically blocks NLRP3 inflammasome activation in macrophages. CY-09 directly binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity, resulting in the suppression of NLRP3 inflammasome assembly and activation. Importantly, treatment with CY-09 shows remarkable therapeutic effects on mouse models of cryopyrin-associated autoinflammatory syndrome (CAPS) and type 2 diabetes. Furthermore, CY-09 is active ex vivo for monocytes from healthy individuals or synovial fluid cells.
ACS Chem Neurosci. 2022 Nov 18.
CY-09 Alleviates the Depression-like Behaviors via Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation in Lipopolysaccharide-Induced Mice
CY-09 purchased from AbMole
| Molecular Weight | 423.43 |
| Formula | C19H12F3NO3S2 |
| CAS Number | 1073612-91-5 |
| Solubility (25°C) | DMSO: ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Pyroptosis Products |
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| INF 195
INF 195 is an NLRP3 inhibitor. |
| Azalamellarin N
Azalamellarin N is an inhibitor of pyroptosis and has different inhibitory effects on different pyroptosis inducers. Azalamellarin N inhibits pyroptosis by targeting molecules that act upstream of NLRP3 inflammasome activation, rather than directly targeting components of the NLRP3 inflammasome. |
| Sodium metatungstate
Sodium metatungstate (Sodium polyoxotungstate) is a potent ecto-nucleoside triphosphate diphosphohydrolase (ENTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively. |
| LDC7559
LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages . |
| MCC950 sodium salt (CP-456773)
MCC950 (CP-456773) sodium salt is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. MCC950 specifically inhibits NLRP3 but not AIM2, NLRC4 or NLRP1 activation. |
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Products are for research use only. Not for human use. We do not sell to patients.
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