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CY-09

Cat. No. M9263
CY-09 Structure
Synonym:

CY09

Size Price Availability Quantity
2mg USD 93  USD93 In stock
5mg USD 120  USD120 In stock
10mg USD 187  USD187 In stock
25mg USD 410  USD410 In stock
100mg USD 1280  USD1280 In stock
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Quality Control
Biological Activity

CY-09 is a selective and direct NLRP3 inhibitor to treat inflammatory disorders. CY-09 specifically blocks NLRP3 inflammasome activation in macrophages. CY-09 directly binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity, resulting in the suppression of NLRP3 inflammasome assembly and activation. Importantly, treatment with CY-09 shows remarkable therapeutic effects on mouse models of cryopyrin-associated autoinflammatory syndrome (CAPS) and type 2 diabetes. Furthermore, CY-09 is active ex vivo for monocytes from healthy individuals or synovial fluid cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 423.43
Formula C19H12F3NO3S2
CAS Number 1073612-91-5
Purity 99.43%
Solubility DMSO: ≥ 60 mg/mL
Storage at -20°C
References

[1] Jiang H, et al. J Exp Med. Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders.

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Keywords: CY-09, CY09 supplier, NLR, inhibitors

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