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Sodium metatungstate

Cat. No. M14494
Sodium metatungstate Structure
Synonym:

Sodium polyoxotungstate; POM-1

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25mg USD 70  USD70 4-7 Days
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Sodium metatungstate (Sodium polyoxotungstate) is a potent ecto-nucleoside triphosphate diphosphohydrolase (ENTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 2986.01
Formula
CAS Number 12141-67-2
Purity >99%
Solubility Water 50 mg/mL
DMSO 50 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Ping Wan, et al. Extracellular ATP mediates inflammatory responses in colitis via P2 × 7 receptor signaling

[2] Nikolay Strigul, et al. Tungsten speciation and toxicity: acute toxicity of mono- and poly-tungstates to fish

[3] Julius Pavlov, et al. Generation and detection of gaseous W12O41-* and other tungstate anions by laser desorption ionization mass spectrometry

[4] Qi Lu, et al. Determination of carbon nanotube density by gradient sedimentation

[5] P G Roessler, et al. Purification of Hydrogenase from Chlamydomonas reinhardtii

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Keywords: Sodium metatungstate, Sodium polyoxotungstate; POM-1 supplier, Phosphatase, inhibitors

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