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Sodium metatungstate (Sodium polyoxotungstate) is a potent ecto-nucleoside triphosphate diphosphohydrolase (ENTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition.
| Molecular Weight | 2986.01 |
| Formula | H2Na6O40W12 |
| CAS Number | 12141-67-2 |
| Solubility (25°C) | Water 50 mg/mL DMSO 40 mg/mL |
| Storage | 2-8°C, dry, sealed |
[4] Qi Lu, et al. Determination of carbon nanotube density by gradient sedimentation
[5] P G Roessler, et al. Purification of Hydrogenase from Chlamydomonas reinhardtii
| Related Pyroptosis Products |
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| Azalamellarin N
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| LDC7559
LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages . |
| CY-09
CY-09 is a selective direct inhibitor of NLRP3 with anti-inflammatory and antidepressant activity, which inhibits inflammatory cytokine production and TRPA1 activation by inhibiting the activation of the NLRP3 inflammatory vesicle, thereby decreasing the intracellular Ca2+ level and reducing the pro-inflammatory polarization of macrophages, alleviating pain and injury in animals. In addition, CY-09 can inhibit pyroptosis. |
| MCC950 sodium salt (CP-456773)
MCC950 (CP-456773) sodium salt is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. MCC950 specifically inhibits NLRP3 but not AIM2, NLRC4 or NLRP1 activation. |
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