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2-Bromohexadecanoic acid

Cat. No. M7584
2-Bromohexadecanoic acid Structure
Synonym:

2-Bromopalmitic acid; 2-Bromopalmitate; 2-BP

Size Price Availability Quantity
100mg USD 50  USD50 In stock
500mg USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

2-Bromohexadecanoic acid (2-Bromopalmitic acid, 2-BP) is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-BP inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis. It has also been shown to inhibit fatty acid oxidation, inhibit DHHC-mediated palmitoylation, and promote glucose uptake in rat cardiac cells and the insulin-sensitive murine fibroblast line A31-IS.

Chemical Information
Molecular Weight 335.32
Formula CH3(CH2)13CH(Br)CO2H
CAS Number 18263-25-7
Solubility (25°C) DMSO > 60 mg/mL
Methanol 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lei Hu, et al. Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate

[2] Han Yao, et al. Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours

[3] Yi Yang, et al. Palmitoylation stabilizes PD-L1 to promote breast tumor growth

[4] Ying Lu, et al. 2-Bromopalmitate targets retinoic acid receptor alpha and overcomes all-trans retinoic acid resistance of acute promyelocytic leukemia

[5] Kojiro Mukai, et al. Activation of STING requires palmitoylation at the Golgi

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Keywords: 2-Bromohexadecanoic acid, 2-Bromopalmitic acid; 2-Bromopalmitate; 2-BP supplier, Pyroptosis, inhibitors, activators


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