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2-Bromohexadecanoic acid (2-Bromopalmitic acid, 2-BP) is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-BP inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis. It has also been shown to inhibit fatty acid oxidation, inhibit DHHC-mediated palmitoylation, and promote glucose uptake in rat cardiac cells and the insulin-sensitive murine fibroblast line A31-IS.
| Molecular Weight | 335.32 |
| Formula | CH3(CH2)13CH(Br)CO2H |
| CAS Number | 18263-25-7 |
| Solubility (25°C) | DMSO > 60 mg/mL Methanol 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Han Yao, et al. Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours
[3] Yi Yang, et al. Palmitoylation stabilizes PD-L1 to promote breast tumor growth
[5] Kojiro Mukai, et al. Activation of STING requires palmitoylation at the Golgi
| Related Pyroptosis Products |
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