| Cat.No. | Name | Information |
|---|---|---|
| M9263 | CY-09 | CY-09 is a selective direct inhibitor of NLRP3 with anti-inflammatory and antidepressant activity, which inhibits inflammatory cytokine production and TRPA1 activation by inhibiting the activation of the NLRP3 inflammatory vesicle, thereby decreasing the intracellular Ca2+ level and reducing the pro-inflammatory polarization of macrophages, alleviating pain and injury in animals. In addition, CY-09 can inhibit pyroptosis. |
| M8083 | MCC950 sodium salt (CP-456773) | MCC950 (CP-456773) sodium salt is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. MCC950 specifically inhibits NLRP3 but not AIM2, NLRC4 or NLRP1 activation. |
| M6164 | MCC950 | MCC950 (CP-456773) is a potent, selective NLRP3 inhibitor with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively. |
| M3390 | Disulfiram | Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1). Disulfiram is used in the study of chronic alcoholism, with acute sensitivity to alcohol, and is a potent copper ion-carrier that can be used in cuproptosis studies. |
| M14494 | Sodium metatungstate | Sodium metatungstate (Sodium polyoxotungstate) is a potent ecto-nucleoside triphosphate diphosphohydrolase (ENTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively. |
| M13554 | LDC7559 | LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages . |
| M7584 | 2-Bromohexadecanoic acid | 2-Bromohexadecanoic acid (2-Bromopalmitic acid, 2-BP) is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. |
| M4363 | Polyphyllin-VI | Polyphyllin VI, an active saponin, has anticancer activity. Polyphyllin VI induces G2/M cell cycle arrest and induces apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis by inducing ROS/NF-κB/NLRP3/GSDMD signaling axis in non-small cell lung cancer. |
| M55903 | INF 195 | INF 195 is an NLRP3 inhibitor. |
| M55214 | Azalamellarin N | Azalamellarin N is an inhibitor of pyroptosis and has different inhibitory effects on different pyroptosis inducers. Azalamellarin N inhibits pyroptosis by targeting molecules that act upstream of NLRP3 inflammasome activation, rather than directly targeting components of the NLRP3 inflammasome. |
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