About 11 results found for searched term "Pyroptosis" (0.118 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3086 | Triclabendazole | Microtubule |
| CGA89317 | ||
| Triclabendazole is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis. Triclabendazole induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. | ||
| M3970 | Scutellarin | STAT |
| Scutellarin, an active flavone isolated from Scutellaria baicalensis, is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively. Scutellarin inhibited caspase-11 activation and pyroptosis in macrophages at least partly via regulating the PKA signaling pathway. | ||
| M4363 | Polyphyllin-VI | Pyroptosis |
| Polyphyllin VI, an active saponin, has anticancer activity. Polyphyllin VI induces G2/M cell cycle arrest and induces apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis by inducing ROS/NF-κB/NLRP3/GSDMD signaling axis in non-small cell lung cancer. | ||
| M9263 | CY-09 | Pyroptosis |
| CY09 | ||
| CY-09 is a selective direct inhibitor of NLRP3 with anti-inflammatory and antidepressant activity, which inhibits inflammatory cytokine production and TRPA1 activation by inhibiting the activation of the NLRP3 inflammatory vesicle, thereby decreasing the intracellular Ca2+ level and reducing the pro-inflammatory polarization of macrophages, alleviating pain and injury in animals. In addition, CY-09 can inhibit pyroptosis. | ||
| M29766 | 7DG | PERK |
| 7-Desacetoxy-6,7-dehydrogedunin | ||
| 7DG (7-Desacetoxy-6,7-dehydrogedunin) is a protein kinase R (PKR) inhibitor. 7DG protects macrophages from lethal toxin-induced pyroptosis. | ||
| M42021 | INF200 | NLR |
| INF200 is a sulfonylurea-based inhibitor of NLRP3 and NLRP3-mediated pyroptosis. | ||
| M43194 | Cathepsin B | Enzymes & Coenzymes |
| Cathepsin B is a cysteine protease and is involved in multiple kinds of programmed cell death (including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death). | ||
| M45372 | NLRP3/AIM2-IN-3 | NLR |
| NLRP3/AIM2-IN-3 is a potent inhibitor that interferes with the interaction of NLRP3 or AIM2 with the bridging protein ASC and inhibits ASC oligomerization, and has different species-specific effects on NLRP3 and AIM2 inflammasome-dependent pyroptosis. In addition, NLRP3/AIM2-IN-3 inhibited LPS/nigericin-stimulated cell pyroptosis in THP-1 macrophages with an IC50 of 0.077 ± 0.008 μM. | ||
| M45373 | NLRP3/AIM2-IN-2 | NLR |
| NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome-dependent cellular pyroptosis, with an IC50 value of 0.2392 ± 0.0233 μM. | ||
| M54577 | Antcin A | NLR |
| Antcin A is an NLRP3 inhibitor that inhibits the assembly and activation of NLRP3 inflammatory vesicles. In addition, Antcin A inhibits pyroptosis of Kupffer cells and has hepatoprotective activity.Antcin A can be used in inflammation-related studies. | ||
| M55214 | Azalamellarin N | Pyroptosis |
| AZL-N | ||
| Azalamellarin N is an inhibitor of pyroptosis and has different inhibitory effects on different pyroptosis inducers. Azalamellarin N inhibits pyroptosis by targeting molecules that act upstream of NLRP3 inflammasome activation, rather than directly targeting components of the NLRP3 inflammasome. | ||
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