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Cat. No. M4893
2-Hydroxypropyl-β-cyclodextrin Structure

Hydroxypropyl betadex; Hydroxypropyl-β-cyclodextrin; HP-β-CD

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
500mg USD 27  USD30 In stock
1g USD 36  USD40 In stock
5g USD 72  USD80 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

2-Hydroxypropyl-β-cyclodextrin functions by forming an inclusion complex with the compound being administered for easier diffusion across biological membranes, and its popularity can be attributed to its large 7 glucose unit cavity size. Some advantageous effects are reduction of negative effects, increased aqueous solubility and increased stability.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1541.54
Formula C63H12O42
CAS Number 128446-35-5
Purity >99%
Solubility Water 50 mg/mL
DMSO 150 mg/mL
Storage at -20°C

Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell Transcription Factor EB
Haocheng Lu, Circulation. 2020 Aug 4;142(5):483-498. PMID: 32354235.

The effects of cyclodextrins on the disposition of intravenously injected drugs in the rat.
Frijlink HW, Pharm Res. 1991 Mar;8(3). PMID: 2052529.

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Keywords: 2-Hydroxypropyl-β-cyclodextrin, Hydroxypropyl betadex; Hydroxypropyl-β-cyclodextrin; HP-β-CD supplier, Solvent & Hydrotropic Agents, inhibitors

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