2-Hydroxypropyl-β-cyclodextrin functions by forming an inclusion complex with the compound being administered for easier diffusion across biological membranes, and its popularity can be attributed to its large 7 glucose unit cavity size. Some advantageous effects are reduction of negative effects, increased aqueous solubility and increased stability.
Cancers (Basel). 2021 May 12;13(10):2310.
Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA
2-Hydroxypropyl-β-cyclodextrin purchased from AbMole
Sci Rep. 2020 Oct 7;10(1):16769.
The effects of fructose and metabolic inhibition on hepatocellular carcinoma
2-Hydroxypropyl-β-cyclodextrin purchased from AbMole
| Molecular Weight | 1541.54 |
| Formula | C63H12O42 |
| CAS Number | 128446-35-5 |
| Solubility (25°C) | Water 50 mg/mL DMSO 150 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Solvents & Excipients Products |
|---|
| Dimethyl sulfoxide
Dimethyl sulfoxide (DMSO) is a commonly used organic solvent with high solvency capacity, soluble in most organic substances such as water, ethanol, propanol, ether, benzene and chloroform, and can be used for the dissolution of compounds and other products. |
| ATX-002
ATX-002 is an ionizable cationic lipid for RNA drug delivery with theoretical pKa (c-pKa) and measured pKa values of 8.68 and 6.03, respectively. |
| 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE is a phospholipid that can be used in studies related to drug delivery. |
| PEG1500
PEG1500 is a polymer produced by the condensation reaction of ethylene oxide and water, generally white waxy solid in appearance, often used as a pharmaceutical excipient. |
| PLGA lactide:glycolide (50:50) (MW 90000)
PLGA lactide:glycolide (50:50) (MW 90000) Poly(D,L-propylidene-CO-ethylidene glycolide) is a synthetic amino acid that can be used for macromolecular delivery. |
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