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PCL-PVAc-PEG is an amphiphilic polymer that enhances the solubility and bioavailability of difficult-to-solve substances and can be used in studies related to drug delivery.
The following is the information about dissolving PCL-PVAc-PEG (Soluplus):
### Recommended Solvents
- **Water**: Soluplus has good solubility in water.
- **Organic Solvents**:
- Acetone: Maximum solubility up to 50%.
- Methanol: Maximum solubility up to 45%.
- Ethanol: Maximum solubility up to 25%.
- Dimethylformamide (DMF): Maximum solubility up to 50%.
- Ethanol/Acetone (1:1 mass ratio): Maximum solubility up to 45%.
- Methanol/Acetone (1:1 mass ratio): Maximum solubility up to 50%.
### Concentration Ranges
- Soluplus has high solubility in water, but high concentrations may lead to turbid or colloidal solutions.
- In organic solvents, concentrations typically range from 10% to 50% (w/w), depending on the solvent and application.
### Dissolution Conditions
- **Temperature**: Soluplus may become turbid at higher temperatures (around 40°C) due to micelle formation (lower critical solution temperature, LCST), but it will return to clarity upon cooling.
- **Stirring**: Gentle stirring is recommended to accelerate dissolution.
- **Mixed Solvents**: Using mixed solvents (e.g., ethanol/acetone or methanol/acetone) can improve dissolution efficiency.
### Optimization Recommendations
1. **Select Suitable Solvents**: Choose appropriate solvents based on the specific application, such as water or organic solvents.
2. **Control Concentration**: Avoid excessively high concentrations to prevent turbidity or colloidal formation.
3. **Temperature Control**: Avoid exceeding the critical dissolution temperature (around 40°C).
4. **Mixing Method**: Use gentle stirring to ensure uniform dissolution.
These recommendations can help optimize the dissolution process of PCL-PVAc-PEG for your experimental needs.
| Molecular Weight | 591.55 |
| Formula | (C8H13NO·C4H6O2·C2H4O)x |
| CAS Number | 402932-23-4 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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