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Methyl α-D-glucopyranoside

Cat. No. M11217
Methyl α-D-glucopyranoside Structure
Synonym:

Methyl α-D-glucoside

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100g USD 50  USD50 In stock
500g USD 120  USD120 In stock
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Biological Activity

Methyl α-D-glucopyranoside can be used in a study to investigate saccharide-mediated protection of chaotropic-induced deactivation of concanavalin A.

Chemical Information
Molecular Weight 194.18
Formula C7H14O6
CAS Number 97-30-3
Solubility (25°C) Water ≥ 500 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sirpa Vuorinen, et al. AAPS PharmSciTech . Sugar end-capped poly-D,L-lactides as excipients in oral sustained release tablets

[2] D N Figlas, et al. Arch Biochem Biophys . Dramatic saccharide-mediated protection of chaotropic-induced deactivation of concanavalin A

[3] Linda Khler, et al. RSC Adv. Binding modes of methyl α-d-glucopyranoside to an artificial receptor in crystalline complexes

[4] Hwei-Ee Tan, et al. Nature. The gut-brain axis mediates sugar preference

[5] Ilham Naoual Taleb-Mokhtari, et al. Spectrochim Acta A Mol Biomol Spectrosc. Vibrational normal modes calculation in the crystalline state of methylated monosaccharides: Anomers of the methyl-D-glucopyranoside and methyl-D-xylopyranoside molecules

[6] Andreas Pikis, et al. J Biol Chem. Genetic requirements for growth of Escherichia coli K12 on methyl-alpha-D-glucopyranoside and the five alpha-D-glucosyl-D-fructose isomers of sucrose

[7] E Brot-Laroche, et al. Biochim Biophys Acta. Characterization of the D-glucose/Na+ cotransport system in the intestinal brush-border membrane by using the specific substrate, methyl alpha-D-glucopyranoside

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Keywords: Methyl α-D-glucopyranoside, Methyl α-D-glucoside supplier, Solvents & Excipients, inhibitors, activators

 
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