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Heparin sodium

Cat. No. M5688
Heparin sodium Structure
Synonym:

Sodium heparinate

Size Price Availability Quantity
100mg USD 50  USD50 In stock
500mg USD 85  USD85 In stock
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Quality Control & Documentation
Biological Activity

Heparin sodium salt, a highly sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule.

Product Citations
Customer Product Validations & Biological Datas
Source INT J NANOMED 2020 Aug. Figure 3. heparin sodium (Abmole Bioscience Inc, Houston, TX, USA)
Method ROS Level of Peripheral Blood Neutrophils analysis
Cell Lines peripheral blood
Concentrations 4 μL of 1% heparin sodium
Incubation Time 2 min
Results There were no significant differences between the groups treated with the CQDs and the negative control group
Chemical Information
Molecular Weight 1157.92
Formula C26H42N2NaO37S5+
CAS Number 9041-08-1
Solubility (25°C) Water 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Daas A, et al. Pharmeur Bio Sci Notes. Collaborative study for the recalibration of Ph. Eur. Heparin sodium BRP batch 3 for chromogenic potency assays.

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Heparin sodium salt (MW 15kDa)

Heparin sodium salt (MW 15kDa) is a heparin polymer with a molecular weight of 15kDa.Heparin sodium salt is an anticoagulant that reversibly binds to antithrombin III (ATIII), thereby accelerating the rate of inactivation of Thrombin factor IIa and factor Xa by ATIII. Heparin sodium salt is used for blood collection and plasma preparation in experimental animals and for the construction of parenteral nutrition models in mice.

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