CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM.
*The compound is unstable in solutions, freshly prepared is recommended
Int Immunopharmacol. 2024 Feb;129:111637.
Fraxin (7-hydroxy-6-methoxycoumarin 8-glucoside) confers protection against ionizing radiation-induced intestinal epithelial injury in vitro and in vivo
CH-223191 purchased from AbMole
Cell Death Dis. 2023 Feb 8;14(2):92.
Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury
CH-223191 purchased from AbMole
J Immunol. 2023 Nov 29;ji2300090.
The Microbial Tryptophan Metabolite Contributes to the Remission of Salmonella typhimurium Infection in Mice
CH-223191 purchased from AbMole
Chemosphere. 2022 Nov;307(Pt 2):135962.
Fine particulate matter induces heart defects via AHR/ROS-mediated endoplasmic reticulum stress
CH-223191 purchased from AbMole
Advances in Clinical Medicine. 13(3), 4166-4175.
The Regulation of Aryl Hydrocarbon Receptor (AhR) in Dry Eye
CH-223191 purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Male ICR mice (6 weeks old) |
| Formulation | 10 mg/kg in corn oil |
| Dosages | 10 mg/kg once a day for 25 days |
| Administration | oral |
| Molecular Weight | 333.39 |
| Formula | C19H19N5O |
| CAS Number | 301326-22-7 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Kuo-Liang Wei, et al. Sorafenib is an antagonist of the aryl hydrocarbon receptor
[5] Lizath M Aguiniga, et al. Acyloxyacyl hydrolase regulates voiding activity
| Related Aryl hydrocarbon Receptor Products |
|---|
| KYN-101
KYN-101 is a potent, selective and orally active AHR inhibitor. |
| AHR agonist 4
AHR agonist 4 is an agonist of Aryl hydrocarbon receptor (AHR), assocaited with the immune balance of Th17/22 and Treg cells. |
| Benzyl butyl phthalate
Benzyl butyl phthalate can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs). |
| Indole-3-ylacetaldehyde
Indole-3-ylacetaldehyde (I3A) |
| 1,4-Chrysenequinone
1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR). |
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