All AbMole products are for research use only, cannot be used for human consumption.
CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM.
*The compound is unstable in solutions, freshly prepared is recommended
Gut Microbes. 2024 May 5;16(1):2347722.
Microbiota-derived I3A protects the intestine against radiation injury by activating AhR/IL-10/Wnt signaling and enhancing the abundance of probiotics
CH-223191 purchased from AbMole
Int Immunopharmacol. 2024 Feb;129:111637.
Fraxin (7-hydroxy-6-methoxycoumarin 8-glucoside) confers protection against ionizing radiation-induced intestinal epithelial injury in vitro and in vivo
CH-223191 purchased from AbMole
Cell Death Dis. 2023 Feb 8;14(2):92.
Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury
CH-223191 purchased from AbMole
J Immunol. 2023 Nov 29;ji2300090.
The Microbial Tryptophan Metabolite Contributes to the Remission of Salmonella typhimurium Infection in Mice
CH-223191 purchased from AbMole
Chemosphere. 2022 Nov;307(Pt 2):135962.
Fine particulate matter induces heart defects via AHR/ROS-mediated endoplasmic reticulum stress
CH-223191 purchased from AbMole
Advances in Clinical Medicine. 13(3), 4166-4175.
The Regulation of Aryl Hydrocarbon Receptor (AhR) in Dry Eye
CH-223191 purchased from AbMole
| Cell Experiment | |
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| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
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| Animal models | Male ICR mice (6 weeks old) |
| Formulation | 10 mg/kg in corn oil |
| Dosages | 10 mg/kg once a day for 25 days |
| Administration | oral |
| Molecular Weight | 333.39 |
| Formula | C19H19N5O |
| CAS Number | 301326-22-7 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Kuo-Liang Wei, et al. Sorafenib is an antagonist of the aryl hydrocarbon receptor
[5] Lizath M Aguiniga, et al. Acyloxyacyl hydrolase regulates voiding activity
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Products are for research use only. Not for human use. We do not sell to patients.
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