KYN-101 is a potent, selective and orally active AHR inhibitor.
| Molecular Weight | 386.42 |
| Formula | C22H19FN6 |
| CAS Number | 2247950-73-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (Need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Aryl hydrocarbon Receptor Products |
|---|
| AHR agonist 4
AHR agonist 4 is an agonist of Aryl hydrocarbon receptor (AHR), assocaited with the immune balance of Th17/22 and Treg cells. |
| Benzyl butyl phthalate
Benzyl butyl phthalate can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs). |
| Indole-3-ylacetaldehyde
Indole-3-ylacetaldehyde (I3A) |
| 1,4-Chrysenequinone
1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR). |
| Carbidopa monohydrate
Carbidopa monohydrate is a dopa decarboxylase (DDC) inhibitor, which can be used for the research of Parkinson's disease. Carbidopa monohydrate is also a selective aryl hydrocarbon receptor (AhR) modulator. |
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