Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist that induces the production of phospholipase A2 inhibitory protein. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses. Dexamethasone also inhibits induction of nitric oxide synthase with IC50 of 5 nM. Dexamethasone reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Dexamethasone induces differentiation of human mesenchymal stem cells (MSCs). Dexamethasone also induces autophagy in acute lymphoblastic leukemia (ALL) cell lines. Dexamethasone is used to treat many inflammatory and autoimmune conditions, such as rheumatoid arthritis and bronchospasm.It can be used to construct models of allergic conjunctivitis.
J Control Release. 2023 Dec 13;365:729-743.
Injectable dexamethasone-loaded peptide hydrogel for therapy of radiation-induced ototoxicity by regulating the mTOR signaling pathway
Dexamethasone purchased from AbMole
Front Pharmacol. 2023 Jul 20;14:1211302.
A Mendelian randomization study for drug repurposing reveals bezafibrate and fenofibric acid as potential osteoporosis treatments
Dexamethasone purchased from AbMole
Pharmacology. 2023 Feb 1;1-10.
DPP4 Inhibitor Sitagliptin Reduces Inflammatory Responses and Mast Cell Activation in Allergic Rhinitis
Dexamethasone purchased from AbMole
Ann Transl Med. 2021 Jul;9(13):1087.
Functional hit 1 (FH1)-based rapid and efficient generation of functional hepatocytes from human mesenchymal stem cells: a novel strategy for hepatic differentiation
Dexamethasone purchased from AbMole
| Molecular Weight | 392.47 |
| Formula | C22H29FO5 |
| CAS Number | 50-02-2 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL Ethanol 8 mg/mL (Need ultrasonic) |
| Storage | 4°C, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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| Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat
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| Heparin sodium salt (MW 15kDa)
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