Featured Products

Cat.No.	Name	Information
M1817	Y-27632 dihydrochloride	Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2.
M1925	LY294002	LY294002 is a highly selective PI3K inhibitor with IC50 values of 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively.
M4839	Cell Counting Kit-8	Cell Counting Kit-8 (CCK-8) allows sensitive colorimetric assays for the determination of cell viability in cell proliferation and cytotoxicity assays.
M1837	MK-2206 2HCl	MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively.
M1902	MG132	MG132 is a specific and potent cell-permeable proteasome inhibitor (IC50 = 100 nM, Ki = 4 nM).
M1732	BMN673	BMN673 is a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2.
M7528	Phosphatase Inhibitor Cocktail (EDTA-Free)	AbMole Phosphatase Inhibitor Cocktail (EDTA-Free) is a mixture of protease inhibitors prepared by 8 independent protease inhibitors according to the optimized ratio. It is divided into A and B two tubes: A tube is a phosphate - root analogue to prevent the loss of phosphorylation of proteins and lipids , and B tube is a new natural product to provide more comprehensive protection for phosphatase.
M1715	GDC-0941	GDC-0941 is a selective and potent inhibitor of Class I PI3K, p110a IC50=0.003uM, U87MG IC50=0.95μM.
M4005	PDTC	PDTC is a selective nuclear factor-κB (NF-κB) inhibitor.
M1820	Tofacitinib	Tofacitinib (formerly tasocitinib, CP-690550) is a novel Janus Kinase 3 (JAK-3) kinase inhibitor with an IC50 value estimated at 0.2 μM.
M1768	Rapamycin	Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling.
M4879	Cycloheximide	Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM.
M1988	Dabrafenib	Dabrafenib (free base) (GSK2118436A) is a V600 mutant BRAF-specific inhibitor.
M1977	U0126	U0126 is a potent and highly selective non-competitive inhibitor of MAPK/ERK kinase with IC50 of 72 nM for MEK1 and 58 nM for MEK2.
M2082	Streptozotocin	Streptozotocin is a small molecule antibiotic and a potent DNA methylating agent.
M1746	DAPT	DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
M2084	SCH772984	SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
M2129	Temozolomide (TMZ)	Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent.
M1646	AG490	AG490 (Tyrphostin AG490) is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively).
M1671	BEZ235	BEZ235 (NVP-BEZ235) is a potent dual PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively.
M1861	CX-4945	CX-4945 (Silmitasertib) is a potent small molecule protein kinase inhibitor that selectively binds to and inhibits the enzyme casein kinase II (CK2).
M5293	Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO)	Protease inhibitor cocktails are used in mammalian cell lysates or tissue extracts to increase protein stability.
M1763	PD-0325901	PD-0325901 is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM.
M1759	GSK1120212 (Trametinib)	GSK1120212 (JTP-74057) is a highly potent and selective MEK inhibitor with IC50 values to be 0.7 and 0.9 nM for MEK1 and MEK2 respectively and with long circulating half-life.
M2223	Cisplatin	Cisplatin is a potent anticancer agent that blocks DNA synthesis.
M1796	XAV939	XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively.
M1637	ABT-263	ABT-263 (Navitoclax) is a potent, orally bioavailable inhibitor of the antiapoptotic Bcl-2 family members Bcl-2, Bcl-x (L), and Bcl-w.
M1966	Fulvestrant	Fulvestrant (Faslodex) is a novel estrogen receptor (ER) antagonist (IC50 = 0.29 nM).
M1712	FTY720	FTY720 (Fingolimod) is a sphingosine-1-phosphate receptor 1 receptor.
M3115	VE-822	VE-822 is an ATR inhibitor with IC50 of 19 nM.
M1781	SB203580	SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3-5 μM.
M2288	Carboplatin	Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism.
M2066	Staurosporine	Staurosporine (AM-2282) is a potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively.
M1738	Niltubacin	Niltubacin, as an inactive derivative of Tubacin, is a highly potent and selective, reversible cell-permeable inhibitor of HDAC6.
M1664	AZD2281 (Olaparib)	AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively.
M1749	Gefitinib	Gefitinib (ZD-1839, Iressa) is a novel potent EGFR tyrosine kinase inhibitor with an IC50 of 0.40nM.
M3722	Temsirolimus	Temsirolimus (CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM.
M2076	SP600125	SP600125 is a novel and selective inhibitor of c-Jun N-terminal kinase (JNK), inhibited phosphorylation of c-Jun with an IC50 of 5-10 microM.
M2048	Sumatriptan succinate	Sumatriptan succinate is a 5-HT1 serotonin receptor agonist.
M1737	MF63	MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme respectively.
M2008	ICG-001	ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription.
M2296	3-Methyladenine (3-MA)	3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM, respectively.
M2108	SB-525334	SB-525334 is a potent activin receptor-like kinase (ALK5)/ type I TGFβ-receptor kinase inhibitor with IC50 of 14.3 nM.
M2080	INCB28060	INCB28060 is a novel inhibitor of c-MET kinase with IC50 of 0.13 nM.
M3932	NVP-TNKS656	NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2.
M3241	Imatinib	Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.
M2112	LY2835219	LY2835219 is an orally available inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM, respectively.
M1802	Lapatinib Ditosylate	Lapatinib Ditosylate (CAS 388082-78-8) is a selective and effective inhibitor of EGFR kinase (Ki = 3 nM), ErbB-2 kinase (Ki = 13 nM) and ErbB-4 kinase (Ki = 347 nM).
M2143	MK-1775	MK-1775 is a potent and selective small molecule Wee1 kinase inhibitor with IC50 of 5.2 nM.
M3030	S-Ruxolitinib	S-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.
M1970	Paclitaxel	Paclitaxel is a mitotic inhibitor with IC50 of 0.1 pM in human endothelial cells.
M2326	Etoposide	Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
M1766	PF-04217903	PF-04217903 (PF-4217903) is a novel ATP-competitive small molecule inhibitor of c-Met kinases with the IC50 values from 3.1 nM to142 nM.
M2053	Wortmannin	Wortmannin is a specific, covalent inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) with IC50 of 3 nM.
M1686	Bortezomib	Bortezomib (Velcade) is a highly selective proteasome inhibitor with a ki value of 6nM.
M1666	AZD8055	AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase (both complexes mTORC1 and mTORC2) with an IC50 of 0.8 nM.
M2302	PF-562271	PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.
M1658	Axitinib	Axitinib (AG013736) inhibits multiple targets including VEGFR, PDGFR and cKit.
M4748	Pectolinarigenin	Pectolinarigenin is a dual inhibitor of COX-2/5-LOX with anti-inflammatory activity.
M2562	ZCL278	ZCL278 is a selective Cdc42 GTPase inhibitor with K_d of 11.4 μM.
M1822	PD98059	PD98059 is a potent and selective inhibitor of mitogen-activated protein kinase kinase (MKK / MEK) with IC50 value of 2-7 μM.
M2283	Rosuvastatin calcium	Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions.
M5228	THZ1	THZ1 is a covalent CDK7 inhibitor which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7.
M2052	Decitabine	Decitabine is a potent inhibitor of DNA methylation for the treatment of myelodysplastic syndromes.
M1680	BKM120	BKM120 (NVP-BKM120) is a potent and highly specific oral pan-class I PI3K inhibitor.
M2277	Semagacestat	Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively.
M2167	(+)-JQ1	(+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.
M1661	AZD6244	AZD6244 (ARRY-142886, Selumetinib) is a potent MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nM.
M1913	Neratinib	Neratinib (HKI-272) is an orally available, irreversible inhibitor of Her 2 tyrosine kinase.
M2017	ABT-199	ABT-199 is a highly potent, orally bioavailable and BCL-2 inhibitor.

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