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Cat.No.  Name Information
M1817 Y-27632 dihydrochloride Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2.
M1925 LY294002 LY294002 is a highly selective PI3K inhibitor with IC50 values of 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively.
M1837 MK-2206 2HCl MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively.
M1715 GDC-0941 GDC-0941 is a selective and potent inhibitor of Class I PI3K, p110a IC50=0.003uM, U87MG IC50=0.95μM.
M1902 MG132 MG132 is a specific and potent cell-permeable proteasome inhibitor (IC50 = 100 nM, Ki = 4 nM).
M1820 Tofacitinib Tofacitinib (formerly tasocitinib, CP-690550) is a novel Janus Kinase 3 (JAK-3) kinase inhibitor with an IC50 value estimated at 0.2 μM.
M1988 Dabrafenib Dabrafenib (free base) (GSK2118436A) is a V600 mutant BRAF-specific inhibitor.
M1861 CX-4945 CX-4945 (Silmitasertib) is a potent small molecule protein kinase inhibitor that selectively binds to and inhibits the enzyme casein kinase II (CK2).
M1759 GSK1120212 (Trametinib) GSK1120212 (JTP-74057) is a highly potent and selective MEK inhibitor with IC50 values to be 0.7 and 0.9 nM for MEK1 and MEK2 respectively and with long circulating half-life.
M4005 PDTC PDTC is a selective NF-kB inhibitor.
M2082 Streptozotocin Streptozotocin is a small molecule antibiotic and a potent DNA methylating agent.
M1746 DAPT DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
M1646 AG490 AG490 (Tyrphostin AG490) is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively).
M2223 Cisplatin Cisplatin is a potent anticancer agent that blocks DNA synthesis.
M2080 INCB28060 INCB28060 is a novel inhibitor of c-MET kinase with IC50 of 0.13 nM.
M1671 BEZ235 BEZ235 (NVP-BEZ235) is a potent dual PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively.
M3115 VE-822 VE-822 is an ATR inhibitor with IC50 of 19 nM.
M1768 Rapamycin Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling.
M1637 ABT-263 ABT-263 (Navitoclax) is a potent, orally bioavailable inhibitor of the antiapoptotic Bcl-2 family members Bcl-2, Bcl-x (L), and Bcl-w.
M1732 BMN673 BMN673 is a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2.
M4839 Cell Counting Kit-8 Cell Counting Kit-8 (CCK-8) allows sensitive colorimetric assays for the determination of cell viability in cell proliferation and cytotoxicity assays.
M2048 Sumatriptan succinate Sumatriptan succinate is a 5-HT1 serotonin receptor agonist.
M1737 MF63 MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme respectively.
M2296 3-Methyladenine 3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM, respectively.
M1977 U0126 U0126 is a potent and highly selective non-competitive inhibitor of MAPK/ERK kinase with IC50 of 72 nM for MEK1 and 58 nM for MEK2.
M2302 PF-562271 PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.
M2017 ABT-199 ABT-199 is a highly potent, orally bioavailable and BCL-2 inhibitor.
M2143 MK-1775 MK-1775 is a potent and selective small molecule Wee1 kinase inhibitor with IC50 of 5.2 nM.
M2084 SCH772984 SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
M1712 FTY720 FTY720 (Fingolimod) is a sphingosine-1-phosphate receptor 1 receptor.
M2066 Staurosporine Staurosporine (AM-2282) is a potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively.
M2129 Temozolomide Temozolomide is an oral DNA methylating, chemotherapeutic agent.
M1738 Niltubacin Niltubacin, as an inactive derivative of Tubacin, is a highly potent and selective, reversible cell-permeable inhibitor of HDAC6.
M3722 Temsirolimus Temsirolimus (CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM.
M1802 Lapatinib Ditosylate Lapatinib Ditosylate (CAS 388082-78-8) is a selective and effective inhibitor of EGFR kinase (Ki = 3 nM), ErbB-2 kinase (Ki = 13 nM) and ErbB-4 kinase (Ki = 347 nM).
M1966 Fulvestrant Fulvestrant (Faslodex) is a novel estrogen receptor (ER) antagonist (IC50 = 0.29 nM).
M4879 Cycloheximide Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM.
M2288 Carboplatin Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism.
M5679 Gefitinib HCl Gefitinib Hcl(ZD-1839 Hcl) is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells. Therefore, it is only effective in cancers with mutated and overactive EGFR.
M1781 SB203580 SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3-5 μM.
M2053 Wortmannin Wortmannin is a specific, covalent inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) with IC50 of 3 nM.
M1970 Paclitaxel Paclitaxel is a mitotic inhibitor with IC50 of 0.1 pM in human endothelial cells.
M1680 BKM120 BKM120 (NVP-BKM120) is a potent and highly specific oral pan-class I PI3K inhibitor.
M3030 S-Ruxolitinib S-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.
M1666 AZD8055 AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase (both complexes mTORC1 and mTORC2) with an IC50 of 0.8 nM.
M2562 ZCL278 ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.
M1763 PD-0325901 PD-0325901 is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM.
M2167 (+)-JQ1 (+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.


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