Featured Products

Cat.No.	Name	Information
M1817	Y-27632 dihydrochloride	Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2.
M4839	Cell Counting Kit-8	Cell Counting Kit-8 (CCK-8) allows sensitive colorimetric assays for the determination of cell viability in cell proliferation and cytotoxicity assays.
M1925	LY294002	LY294002 is a highly selective PI3K inhibitor with IC50 values of 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively.
M1837	MK-2206 2HCl	MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively.
M1902	MG132	MG132 is a specific and potent cell-permeable proteasome inhibitor (IC50 = 100 nM, Ki = 4 nM).
M1768	Rapamycin	Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling.
M7528	Phosphatase Inhibitor Cocktail (EDTA-Free)	AbMole Phosphatase Inhibitor Cocktail (EDTA-Free) is a mixture of phosphatase inhibitors prepared by 8 independent phosphatase inhibitors according to the optimized ratio. It is divided into A and B two tubes: A tube is a phosphate - root analogue to prevent the loss of phosphorylation of proteins and lipids, and B tube is a new natural product to provide more comprehensive protection for phosphorylation.
M1732	BMN673	BMN673 is a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2.
M4005	PDTC	PDTC is a selective nuclear factor-κB (NF-κB) inhibitor.
M1820	Tofacitinib	Tofacitinib (formerly tasocitinib, CP-690550) is a novel Janus Kinase 3 (JAK-3) kinase inhibitor with an IC50 value estimated at 0.2 μM.
M1715	GDC-0941	GDC-0941 is a selective and potent inhibitor of Class I PI3K, p110a IC50=0.003uM, U87MG IC50=0.95μM.
M3850	Dimethyl sulfoxide	Dimethyl sulfoxide (abbreviated DMSO) is a common organic solvent which has the strongest dissolving ability, it can dissolve most of the organic compounds.
M4879	Cycloheximide	Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM.
M1977	U0126	U0126 is a potent and highly selective non-competitive inhibitor of MAPK/ERK kinase with IC50 of 72 nM for MEK1 and 58 nM for MEK2.
M1637	ABT-263	ABT-263 (Navitoclax) is a potent, orally bioavailable inhibitor of the antiapoptotic Bcl-2 family members Bcl-2, Bcl-x (L), and Bcl-w.
M1712	FTY720	FTY720 (Fingolimod) is a sphingosine-1-phosphate receptor 1 receptor.
M1781	SB203580	SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3-5 μM.
M1988	Dabrafenib	Dabrafenib (free base) (GSK2118436A) is a V600 mutant BRAF-specific inhibitor.
M2082	Streptozotocin	Streptozotocin is a small molecule antibiotic and a potent DNA methylating agent.
M1759	GSK1120212 (Trametinib)	GSK1120212 (JTP-74057) is a highly potent and selective MEK inhibitor with IC50 values to be 0.7 and 0.9 nM for MEK1 and MEK2 respectively and with long circulating half-life.
M2129	Temozolomide (TMZ)	Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent.
M2084	SCH772984	SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
M1646	AG490	AG490 (Tyrphostin AG490) is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively).
M1749	Gefitinib	Gefitinib (ZD-1839, Iressa) is a novel potent EGFR tyrosine kinase inhibitor with an IC50 of 0.40nM.
M5293	Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO)	Protease inhibitor cocktails are used in mammalian cell lysates or tissue extracts to increase protein stability.
M1671	BEZ235	BEZ235 (NVP-BEZ235) is a potent dual PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively.
M2076	SP600125	SP600125 is a novel and selective inhibitor of c-Jun N-terminal kinase (JNK), inhibited phosphorylation of c-Jun with an IC50 of 5-10 microM.
M2296	3-Methyladenine (3-MA)	3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM, respectively.
M4947	Streptomycin sulfate	Streptomycin sesquisulfate is an antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.
M1763	PD-0325901	PD-0325901 is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM.
M1861	CX-4945	CX-4945 (Silmitasertib) is a potent small molecule protein kinase inhibitor that selectively binds to and inhibits the enzyme casein kinase II (CK2).
M1746	DAPT	DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
M3115	VE-822	VE-822 is an ATR inhibitor with IC50 of 19 nM.
M1966	Fulvestrant	Fulvestrant (Faslodex) is a novel estrogen receptor (ER) antagonist (IC50 = 0.29 nM).
M2066	Staurosporine	Staurosporine (AM-2282) is a potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively.
M1822	PD98059	PD98059 is a potent and selective inhibitor of mitogen-activated protein kinase kinase (MKK / MEK) with IC50 value of 2-7 μM.
M5868	Penicillin G Sodium	Penicillin G Sodium is a β-lactam antibiotic produced by Penicillin spp.
M1738	Niltubacin	Niltubacin, as an inactive derivative of Tubacin, is a highly potent and selective, reversible cell-permeable inhibitor of HDAC6.
M1686	Bortezomib	Bortezomib (Velcade) is a highly selective proteasome inhibitor with a ki value of 6nM.
M3722	Temsirolimus	Temsirolimus (CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM.
M2108	SB-525334	SB-525334 is a potent activin receptor-like kinase (ALK5)/ type I TGFβ-receptor kinase inhibitor with IC50 of 14.3 nM.
M2288	Carboplatin	Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism.
M2326	Etoposide	Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
M2048	Sumatriptan succinate	Sumatriptan succinate is a 5-HT1 serotonin receptor agonist.
M1658	Axitinib	Axitinib (AG013736) inhibits multiple targets including VEGFR, PDGFR and cKit.
M1737	MF63	MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme respectively.
M2008	ICG-001	ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription.
M1709	Everolimus	Everolimus (RAD001) also known as SDZ-RAD and Certican is an mTOR inhibitor with IC50 of 0.63 nM.
M2223	Cisplatin	Cisplatin is a potent anticancer agent that blocks DNA synthesis.
M3241	Imatinib	Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.
M1796	XAV939	XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively.
M1664	AZD2281 (Olaparib)	AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively.
M2080	INCB28060	INCB28060 is a novel inhibitor of c-MET kinase with IC50 of 0.13 nM.
M2748	GW9662	GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM, with at least 100 to 1000-fold functional selectivity in cells with PPARγ versus PPARα and PPARδ.
M1661	AZD6244	AZD6244 (ARRY-142886, Selumetinib) is a potent MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nM.
M1809	NU7441	NU7441 (KU 57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 values of 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively.
M1802	Lapatinib Ditosylate	Lapatinib Ditosylate (CAS 388082-78-8) is a selective and effective inhibitor of EGFR kinase (Ki = 3 nM), ErbB-2 kinase (Ki = 13 nM) and ErbB-4 kinase (Ki = 347 nM).
M1913	Neratinib	Neratinib (HKI-272) is an orally available, irreversible inhibitor of Her 2 tyrosine kinase.
M1761	PLX4032	PLX4032 (Vemurafenib, RG7204, RO5185426 and Zelboraf) is a highly selective B-Raf enzyme inhibitor with an IC50 of 44 nM against V600E-mutant BRAF.
M3932	NVP-TNKS656	NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2.
M4748	Pectolinarigenin	Pectolinarigenin is a dual inhibitor of COX-2/5-LOX with anti-inflammatory activity.
M2510	Chloroquine diphosphate	Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent.
M2052	Decitabine	Decitabine is a potent inhibitor of DNA methylation for the treatment of myelodysplastic syndromes.
M5307	Afatinib dimaleate	Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.
M4838	TAK-242	TAK-242 (Resatorvid) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling.
M3030	S-Ruxolitinib	S-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.
M1666	AZD8055	AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase (both complexes mTORC1 and mTORC2) with an IC50 of 0.8 nM.
M2143	MK-1775	MK-1775 is a potent and selective small molecule Wee1 kinase inhibitor with IC50 of 5.2 nM.
M6118	666-15	666-15 is a potent and selective CREB inhibitor with an IC50 of 81 nM.
M9650	Triazavirin	Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent, works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments.
M2562	ZCL278	ZCL278 is a selective Cdc42 GTPase inhibitor with K_d of 11.4 μM.
M3026	Sorafenib	Sorafenib is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.
M2053	Wortmannin	Wortmannin is a specific, covalent inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) with IC50 of 3 nM.
M1708	EX 527	EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 98 nM.
M1766	PF-04217903	PF-04217903 (PF-4217903) is a novel ATP-competitive small molecule inhibitor of c-Met kinases with the IC50 values from 3.1 nM to142 nM.
M2283	Rosuvastatin calcium	Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions.
M1970	Paclitaxel	Paclitaxel is a mitotic inhibitor with IC50 of 0.1 pM in human endothelial cells.
M3982	Cryptotanshinone	Cryptotanshinone is a potent anticancer agent targeting the activation STAT3 protein with antitumor activity.
M2302	PF-562271	PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.
M8083	CP-456773 sodium salt	CP-456773 sodium salt (MCC950) was found to act as a cytokine release inhibitory drug and inhibitor of the NLRP3 inflammasome.
M2071	ONX-0914	ONX-0914 (PR-957) is a potent and selective immunoproteasome inhibitor.
M1648	AP24534	Ponatinib (AP24534) is a novel potent, orally available small molecule multitargeted kinase inhibitor of BCR-ABL, PDGFRα, c-Src, c-Kit, FGFR and VEGFR.
M2112	LY2835219	LY2835219 is an orally available inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM, respectively.
M1701	Dasatinib	Dasatinib (BMS-354825) is a small molecule inhibitor of both the SRC and BCR/ABL tyrosine kinases, with IC50's for the isolated kinases of 0.55 and 3.0 nM, respectively.
M2277	Semagacestat	Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively.
M2081	LY2109761	LY2109761 is a novel TGF-β receptor type I and type II dual inhibitor.
M2167	(+)-JQ1	(+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.
M5228	THZ1	THZ1 is a covalent CDK7 inhibitor which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7.
M2017	ABT-199	ABT-199 is a highly potent, orally bioavailable and BCL-2 inhibitor.
M1680	BKM120	BKM120 (NVP-BKM120) is a potent and highly specific oral pan-class I PI3K inhibitor.

Signaling Pathways

Product Type

Featured Products

Get to Know Us

Customer Support

Resources

Contact Us