Featured Products

Cat.No.	Name	Information
M1925	LY294002	LY294002 is a highly selective PI3K inhibitor with IC50 values of 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively.
M1817	Y-27632 dihydrochloride	Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2.
M1837	MK-2206 2HCl	MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively.
M1988	Dabrafenib	Dabrafenib (free base) (GSK2118436A) is a V600 mutant BRAF-specific inhibitor.
M1902	MG132	MG132 is a specific and potent cell-permeable proteasome inhibitor (IC50 = 100 nM, Ki = 4 nM).
M1861	CX-4945	CX-4945 (Silmitasertib) is a potent small molecule protein kinase inhibitor that selectively binds to and inhibits the enzyme casein kinase II (CK2).
M2082	Streptozotocin	Streptozotocin is a small molecule antibiotic and a potent DNA methylating agent.
M1820	Tofacitinib	Tofacitinib (formerly tasocitinib, CP-690550) is a novel Janus Kinase 3 (JAK-3) kinase inhibitor with an IC50 value estimated at 0.2 μM.
M1759	GSK1120212 (Trametinib)	GSK1120212 (JTP-74057) is a highly potent and selective MEK inhibitor with IC50 values to be 0.7 and 0.9 nM for MEK1 and MEK2 respectively and with long circulating half-life.
M1768	Rapamycin	Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling.
M1746	DAPT	DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
M1732	BMN673	BMN673 is a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2.
M1637	ABT-263	ABT-263 (Navitoclax) is a potent, orally bioavailable inhibitor of the antiapoptotic Bcl-2 family members Bcl-2, Bcl-x (L), and Bcl-w.
M4005	PDTC	PDTC is a selective NF-kB inhibitor.
M2223	Cisplatin	Cisplatin is a potent anticancer agent that blocks DNA synthesis.
M2048	Sumatriptan succinate	Sumatriptan succinate is a 5-HT1 serotonin receptor agonist.
M3115	VE-822	VE-822 is an ATR inhibitor with IC50 of 19 nM.
M1671	BEZ235	BEZ235 (NVP-BEZ235) is a potent dual PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively.
M1737	MF63	MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme respectively.
M4839	Cell Counting Kit-8	Cell Counting Kit-8 (CCK-8) allows sensitive colorimetric assays for the determination of cell viability in cell proliferation and cytotoxicity assays.
M2296	3-Methyladenine	3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM, respectively.
M1715	GDC-0941	GDC-0941 is a selective and potent inhibitor of Class I PI3K, p110a IC50=0.003uM, U87MG IC50=0.95μM.
M2080	INCB28060	INCB28060 is a novel inhibitor of c-MET kinase with IC50 of 0.13 nM.
M2562	ZCL278	ZCL278 is a selective Cdc42 GTPase inhibitor with K_d of 11.4 μM.
M1977	U0126	U0126 is a potent and highly selective non-competitive inhibitor of MAPK/ERK kinase with IC50 of 72 nM for MEK1 and 58 nM for MEK2.
M2084	SCH772984	SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
M1966	Fulvestrant	Fulvestrant (Faslodex) is a novel estrogen receptor (ER) antagonist (IC50 = 0.29 nM).
M1646	AG490	AG490 (Tyrphostin AG490) is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively).
M1712	FTY720	FTY720 (Fingolimod) is a sphingosine-1-phosphate receptor 1 receptor.
M1781	SB203580	SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3-5 μM.
M2066	Staurosporine	Staurosporine (AM-2282) is a potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively.
M1738	Niltubacin	Niltubacin, as an inactive derivative of Tubacin, is a highly potent and selective, reversible cell-permeable inhibitor of HDAC6.
M2143	MK-1775	MK-1775 is a potent and selective small molecule Wee1 kinase inhibitor with IC50 of 5.2 nM.
M3030	S-Ruxolitinib	S-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.
M3722	Temsirolimus	Temsirolimus (CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM.
M4879	Cycloheximide	Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM.
M2129	Temozolomide	Temozolomide is an oral DNA methylating, chemotherapeutic agent.
M2053	Wortmannin	Wortmannin is a specific, covalent inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) with IC50 of 3 nM.
M2302	PF-562271	PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.
M1802	Lapatinib Ditosylate	Lapatinib Ditosylate (CAS 388082-78-8) is a selective and effective inhibitor of EGFR kinase (Ki = 3 nM), ErbB-2 kinase (Ki = 13 nM) and ErbB-4 kinase (Ki = 347 nM).
M5679	Gefitinib HCl	Gefitinib Hcl(ZD-1839 Hcl) is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells. Therefore, it is only effective in cancers with mutated and overactive EGFR.
M2288	Carboplatin	Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism.
M2167	(+)-JQ1	(+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.
M1970	Paclitaxel	Paclitaxel is a mitotic inhibitor with IC50 of 0.1 pM in human endothelial cells.
M1680	BKM120	BKM120 (NVP-BKM120) is a potent and highly specific oral pan-class I PI3K inhibitor.
M1666	AZD8055	AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase (both complexes mTORC1 and mTORC2) with an IC50 of 0.8 nM.
M2017	ABT-199	ABT-199 is a highly potent, orally bioavailable and BCL-2 inhibitor.

Signaling Pathways

Product Type

Featured Products

Get to Know Us

Customer Support

Resources

Contact Us