Cytarabine is an antimetabolic agent and a DNA polymerase with an IC50 of 16 nM for wild-type CCRF-CEM cells.Cytarabine is used mainly in the treatment of hematological malignancies such as acute myeloid leukemia (AML) and non-Hodgkin lymphoma. Cytarabine also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair.
Biochem Pharmacol. 2024 Feb 17;116065.
Panobinostat sensitizes AraC-resistant AML cells to the combination of azacitidine and venetoclax
Cytarabine purchased from AbMole
Neoplasma. 2023 Feb 23;221217N1185.
Synergistic activity and mechanism of cytarabine and MCL-1 inhibitor AZD5991 against acute myeloid leukemia
Cytarabine purchased from AbMole
Cells. 2022 Sep 3;11(17):2752.
Inhibition of Mcl-1 Synergistically Enhances the Antileukemic Activity of Gilteritinib and MRX-2843 in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia
Cytarabine purchased from AbMole
BMC Biol. 2021 May 20;19(1):108.
Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans
Cytarabine purchased from AbMole
Redox Biol. 2019 Jun;24:101153.
Peperomin E and its orally bioavailable analog induce oxidative stress-mediated apoptosis of acute myeloid leukemia progenitor cells by targeting thioredoxin reductase.
Cytarabine purchased from AbMole
| Molecular Weight | 243.22 |
| Formula | C9H13N3O5 |
| CAS Number | 147-94-4 |
| Solubility (25°C) | Water 34 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] D J Murry, et al. Clinical pharmacology of encapsulated sustained-release cytarabine
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Polynucleotide Kinase is a DNA repair enzyme. |
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