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Gemcitabine

Cat. No. M5680
Gemcitabine Structure
Size Price Availability Quantity
100mg USD 80 In stock
100mg USD 80 In stock
200mg USD 120 In stock
200mg USD 120 In stock
500mg USD 220 In stock
500mg USD 220 In stock
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Quality Control
Biological Activity

Gemcitabine(LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 263.2
Formula C9H11F2N3O4
CAS Number 95058-81-4
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Gemcitabine resistance in pancreatic ductal adenocarcinoma.
Binenbaum Y, et al. Drug Resist Updat. 2015 Nov;23:55-68. PMID: 26690340.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Gemcitabine supplier, DNA/RNA Synthesis, inhibitors

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