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Dorsomorphin (Compound C) dihydrochloride

Cat. No. M2238
Dorsomorphin (Compound C) dihydrochloride Structure

BML-275 2HCl; Compound C 2HCl

Size Price Availability Quantity
10mM*1mL In DMSO USD 65 In stock
5mg USD 59 In stock
10mg USD 86 In stock
50mg USD 305 In stock
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Quality Control
Biological Activity

Dorsomorphin dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM) and bone morphogenic protein (BMP) signaling. Dorsomorphin dihydrochloride inhibits AMPK activation induced by AICAR and metformin. Dorsomorphin dihydrochloride also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6). Dorsomorphin dihydrochloride induces autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.

Product Citations
Customer Product Validations & Biological Datas
Source Hum Mol Genet (2016). Figure 2. Dorsomorphin dihydrochloride
Method RT-qPCR
Cell Lines iPSC lines
Concentrations 1 μM
Incubation Time 72 h
Results We generated cortical neurons using a well-established protocol with small molecule dual SMAD inhibition for neural induction followed by plating of neuroepithelial cells for final differentiation
Cell Experiment
Cell lines Spermatogonial Cell
Preparation method Dorsomorphin was added to the medium at a final concentration of 0, 1, 2, 4, or 8 µM (in final 0.4% dimethyl sulfoxide). The cells were maintained at 28.5°C in an atmosphere of 3% carbon dioxide and the medium was replaced every 3–4 days.
Concentrations 0, 1, 2, 4, or 8 µM
Incubation time 3 weeks
Animal Experiment
Animal models C57BL/6 mice
Formulation DMSO
Dosages 10 mg/kg
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 472.41
Formula C24H25N5O.2HCl
CAS Number 1219168-18-9
Purity >99%
Solubility Water 47 mg/mL
Storage at -20°C

Dorsomorphin promotes survival and germline competence of zebrafish spermatogonial stem cells in culture.
Wong TT, et al. PLoS One. 2013 Aug 1;8(8):e71332. PMID: 23936500.

Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.
Yu PB, et al. Nat Chem Biol. 2008 Jan;4(1):33-41. PMID: 18026094.

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Keywords: Dorsomorphin (Compound C) dihydrochloride, BML-275 2HCl; Compound C 2HCl supplier, AMPK, inhibitors

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