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M10677 β-Melanocyte Stimulating Hormone TFA, human β-Melanocyte Stimulating Hormone TFA, human is a 22-residue peptide, which acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.
M10676 Tegoprazan Tegoprazan (CJ-12420, IN-A001, K-CAB, LXI-15028) is a potassium-competitive acid blocker and a potent, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro.
M10675 (2-Aminoethyl)phosphonic acid (2-Aminoethyl)phosphonic acid is a type of abundant and ubiquitous naturally occurring phosphonate used as sources of phosphorus by many prokaryotic lineages.
M10674 Prosapogenin A Prosapogenin A is a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis.
M10673 Procyanidin C1 Procyanidin C1 (PCC1) is a natural polyphenol, which causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells.
M10672 Thonningianin A Thonningianin A is an ellagitannin with anti-cancer activities. Thonningianin A also has antioxidant properties of radical scavenging, anti-superoxide formation and metal chelation.
M10671 Garcinone E Garcinone E is the most active xanthone from mangosteen, which has potent cytotoxic effect against hepatocellular carcinoma cell lines. Garcinone E might inhibit metastasis of an oral cancer cell line by blocking invasion, migration and MMP production.
M10670 Acetyl Coenzyme A trisodium Acetyl Coenzyme A trisodium (Acetyl-CoA trisodium) is a central metabolic intermediate. Acetyl Coenzyme A trisodium is the actual molecule through which glycolytic pyruvate enters the tricarboxylic acid (TCA) cycle, is a key precursor of lipid synthesis, and is the sole donor of the acetyl groups for acetylation. Acetyl Coenzyme A trisodium acts as a potent allosteric activator of pyruvate carboxylase (PC).
M10669 Recombinant Human/Murine/Rat Activin A (CHO) Activin A is a homodimer of two βA chains that is involved in tissue morphogenesis and repair, fibrosis, inflammation, neural development, hematopoiesis, reproductive system function, and carcinogenesis. Activin A protects the heart from hypoxic stress and promotes the differentiation of embryonic stem cells into cardiomyocytes.
M10668 BRM/BRG1 ATP Inhibitor-1 BRM/BRG1 ATP Inhibitor-1 is an orally active inhibitor (IC50 below 5 nM) of Brahma Homolog (BRM)​/SMARCA2 ATPase activity for the treatment of Brahma Related Gene 1 (BRG1)​/SMARCA4-​Mutant cancers.
M10667 UTL-5g UTL-5g is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hematotoxicity.
M10666 CW069 CW069 is an allosteric inhibitor of HSET with IC50 of 75 μM, it showed marked activity against HSET in vitro.
M10665 Masitinib mesylate Masitinib (AB-1010) mesylate is a potent, orally bioavailable and selective inhibitor of c-Kit, IC50 of 200 nM for human recombinant c-Kit. It also inhibits PDGFRα/β, LynB with IC50 values of 540, 800 and 510 nM.
M10664 Isovitexin Isovitexin is a flavonoid isolated from rice hulls of Oryza sativa, possesses anti-inflammatory and anti-oxidant activities. Isovitexin inhibits the activation of NF-κB.
M10663 Alcesefoliside Alcesefoliside is a flavonoid isolated from Nitraria sibirica Pall, with antioxidant activity
M10662 Camelliaside A Camelliaside A is a flavonoid from the methanol extract of tea (Camellia oleifera) seed pomace.
M10661 Tabersonine Tabersonine is an indole alkaloid mainly isolated from Catharanthus roseus. Tabersonine has anti-inflammatory activities and acts as a potential therapeutic candidate for the treatment of ALI/ARDS.
M10660 (-)-Syringaresinol (-)-Syringaresinol has anti-cancer activity.
M10659 Picfeltarraenin IV Picfeltarraenin IV is an acetylcholinesterase (AChE) inhibitor, which is obtained from Picriafel-terrae Lour (P.fel-terrae).
M10658 Calenduloside E Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90).
M10657 Purpureaside C Purpureaside C is a phenolic glycoside which has significant proinflammatory activity.
M10656 Bergaptol Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.
M10655 Picfeltarraegenin X Picfeltarraenin X is an AChE inhibitor, which is a triterpenoid isolated from Picria fel-terrae Lour.
M10654 Ajmalicine (Raubasine) Ajmalicine (Raubasine) is an adrenolytic agent which preferentially blocks alpha 1-adrenoceptor than alpha 2-adrenoceptor. Ajmalicine (Raubasine) is an reversible non-competitive nicotine receptor antagonist with an IC50 of 72.3 μM.
M10653 Dehydroevodiamine Dehydroevodiamine has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.
M10652 Voacamine Voacamine is an indole alkaloid, exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells.
M10651 Shikimic acid Shikimic acid is an important metabolic intermediate with various applications. Shikimic acid is an industrially important compound that acts as a precursor in the synthesis of many chemical substances like oseltamivir phosphate.
M10650 Periplogenin Periplogenin is a naturally occurring furanocoumarin found in Angelica dahurica roots, with potent anti-psoriatic effects. Periplogenin induces adipocyte differentiation.
M10649 DL-α-Tocopherol (Liquid) DL-α-Tocopherol is used as an antioxidant that protects cell membrane lipids from oxidative damage.
M10648 Alagebrium chloride Alagebrium Chloride, also known as ALT711, is an advanced glycation end product (AGE) inhibitor.
M10647 Diphenylterazine Diphenylterazine is a bioluminescence agent. Diphenylterazine alone yields very little background, leading to excellent signal-to-background ratios. DMSO can inactivate Diphenylterazine's activity
M10646 GRP-60367 hydrochloride GRP-60367 hydrochloride is a first-in-class potent and selective inhibitor of rabies virus (RABV) entry that specifically targets the RABV G protein.
M10645 MS402 MS402 is a novel BD1-selective BET BrD inhibitor, inhibiting primarily Th17 cell differentiation with a little or almost no effect on Th1 or Th2 and Treg cells. MS402 has Ki values of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively.
M10644 L-765314 L-765314 is a potent and selective antagonist of α1b adrenergic receptor with Ki of 5.4 nM and 2.0 nM for rat and human α1b adrenergic receptor, respectively.
M10643 Benpyrine racemate Benpyrine racemate ((Rac)-Benpyrine) is a racemate of Benpyrine, Benpyrine racemate ((Rac)-Benpyrine) is a potent and orally active TNF-α inhibitor and has the potential for TNF-α mediated inflammatory and autoimmune disease research.
M10642 ML382 ML382 is a potent and selective MrgX1 (Mas-related G protein-coupled receptor X1, MRGPRX1) positive allosteric modulator with EC50 of 190 nM.
M10641 FOY-251 mesylate FOY-251 mesylate is a metabolite of Camostat that acts as a pollen protease inhibitor for prevention and control of allergies.
M10640 Uricase Uricase is a new type of uric acid-lowering compound, also known as Urate Oxidase, it is characterized by promoting the decomposition of uric acid, catalyzes the rapid oxidation of uric acid into allantoic acid, which is no longer reabsorbed and excreted by the renal tubules, thereby reducing the content of uric acid in the plasma.
M10639 6-Hydroxypurine 6-Hydroxypurine is a potential free radical generator and could be used as an indicator of hypoxia.
M10638 Recombinant Human Interleukin-31 (E. coli) Human Interleukin-33 (IL-33) is a proinflammatory cytokine that belongs to the IL-1 family. IL-33 plays a role in autoimmune disease. IL-33’s interaction with ST2 can drive allergic pathology and IL-33 has been reported to play a role in the development of rheumatoid arthritis and systemic lupus erythematosus.
M10637 GSK3368715 2HCl GSK3368715 2HCl is a novel potent, orally active, reversible type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50 values of 3.1 nM, 48 nM, 1148 nM, 5.7 nM and 1.7 nM for PRMT1, PRMT3, PRMT4, PRMT6, PRMT8, respectively.
M10636 Echistatin TFA Echistatin TFA is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1.
M10635 Fumaric acid Fumaric acid (Fumarate, 2-Butenedioic acid, Trans-Butenedioic acid) is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food.
M10634 NE 52-QQ57 NE 52-QQ57 is an orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 significantly inhibited the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).
M10633 AS601245 AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50 values of 150, 220, and 70 nM for JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively.
M10632 AM211 AM-211 is a novel and potent antagonist of the prostaglandin D2 receptor type 2, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.
M10631 Enpp-1-IN-1 Enpp-1-IN-1, also known as MV 658, is a Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) inhibitor.
M10630 GW280264X GW280264X is an ADAM17 inhibitor.
M10629 Troxerutin Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.
M10628 Adenosine amine congener Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and cisplatin-induced cochlear injury.
M10627 RGX-104 hydrochloride RGX-104 hydrochloride is a small-molecule LXR (liver X receptor) agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
M10626 UAMC-3203 UAMC-3203 is an improved ferroptosis inhibitor, with an IC50 value of 10 nM in IMR-32 neuroblastoma cells.
M10625 GSK2193874 GSK2193874 is a first-in-class orally bioavailable potent antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist with IC50 values of 2, 5, and 40 nM. GSK2193874 is the first-in-class orally bioavailable TRPV4 inhibitor that demonstrated ability to improve pulmonary functions in a number of heart failure models.
M10624 Tetraethylammonium chloride Tetraethylammonium chloride is a non-selective potassium channel blocker with antitumor properties.
M10623 Dehydronuciferine Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC50 of 25 μg/mL
M10622 Hederacoside D Hederacoside D is one of the bioactive saponins from Hedera helix, and plays pivotal roles in the overall biological activity.
M10621 Iristectorigenin B Iristectorigenin B is a liver X receptor (LXR) modulator, which stimulates the transcriptional activity of both LXR-α and LXR-β.
M10620 Kudinoside D Kudinoside D is a main natural component of triterpenoid saponin derived from Ilex kudingcha. Kudinoside D suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes.
M10619 Rhodiosin Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.420 μM and a Ki of 0.535 μM. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL.
M10618 Cassiaside C Cassiaside C (Toralactone 9-O-β-D-gentiobioside) is a naphthopyrone isolated from the seed of Cassia tora and has inhibitory activity on advanced glycation end products (AGE) formation in vitro.
M10617 Iristectorin A Iristectorin A is a natural product from Iris tectorum with anti-cancer activities in breast cancer.
M10616 Picfeltarraenin IA Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor.
M10615 N-Formylcytisine N-Formylcytisine is a cytisine-type alkaloid from the stem bark of Maackia amurensis.
M10614 Buddlejasaponin IVb Buddlejasaponin IVb is a triterpene saponin isolated from Clinopodium chinense (Benth.) O. Kuntze, with hemostasis efficacy, shortens thrombin time.
M10613 Vitexin-4-O-glucoside Vitexin-4''-O-glucoside is a flavonoid derived from the leaves of Crataegus pinnatifida.
M10612 4-Nitroquinoline N-oxide 4-Nitroquinoline N-oxide (4-NQO) corrects DNA damage through nucleotide excision repair. 4NQO may induce DNA damage by generating reactive oxygen species thought to be produced by the enzymatic reduction of its nitro group.
M10611 QS-21 QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18.
M10610 Recombinant Human Fibroblast Growth Factor 9 (E. coli) Fibroblast growth factor-9 (FGF-9) is a steroid-regulated mitogen and survival factor for nerve and mesenchymal cells.
M10609 Ergothioneine Ergothioneine is an imidazole-2-thione derivative of histidine betaine, generally considered as an antioxidant.
M10608 NLX-101 (F-15599) NLX-101 (F-15599) is a highly selective G-protein biased 5-HT1A receptor agonist, with Ki of 3.4 nM. NLX-101 (F-15599) mediates antidepressant-like activity in rats via prefrontal cortex 5-HT 1A receptors. NLX-101 (F-15599) has over 1000-fold higher affinity for this target over other receptors.
M10607 NUN82647 (CU-242) NUN82647 (2-Amino-N-quinolin-8-yl-benzenesulfonamide, QBS, CU-242) is an inhibitor of cell cycle at G2 phase; it is also an apoptosis inducer.
M10606 Radiprodil (RGH-896) Radiprodil (also known as RGH-896) is an orally active and selective NMDA receptors antagonist which was evaluated as potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP).
M10605 Rilzabrutinib Rilzabrutinib, also known as PRN1008, is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK) with IC50 of 1.3 nM.
M10604 Pirtobrutinib (LOXO-305) Pirtobrutinib (LOXO-305; LY 3527727; RXC-005) is a highly selective and non-covalent next generation BTK inhibitor, which inhibits diverse BTK C481 substitution mutations. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases.
M10603 Anti-human CD28 mAb CD28 molecule exists on the surface of most T cells and is considered to be a specific surface molecule of T cells. The responsiveness of T cells to antigens is mainly mediated by the CD3/TCR complex, but it also depends on the cooperation of other molecules on the surface of T cells.
M10602 Necrostatin 2 racemate Necrostatin-2 racemate (also known as 7-Cl-O-Nec-1 and Nec-1s) is a potent and specific receptor-interacting protein kinase 1 (RIPK1) inhibitor lacking the IDO-targeting effect, with >1000-fold more selective for RIPK1 than for any other kinase out of 485 human kinases.
M10601 SCF, Mouse (P. pastoris) Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117). It stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors.
M10600 SAH-SOS1A TFA SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM) and directly and independently blocks nucleotide association.
M10599 PF-543 HCl PF-543 hydrochloride is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2.
M10598 SPHINX31 SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1) with IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1).
M10597 Pamoic acid disodium Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively.
M10596 BIBF0775 BIBF0775 is a potent and selective inhibitor of the transforming growth factor β receptor I (TGFβRI, Alk5) with an IC50 of 34 nM.
M10595 MLi-2 MLi-2 is a highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM).
M10594 PF-07321332 PF-07321332, also known as Paxlovid, is an orally bioavailable 3C-like protease (3CLPRO) inhibitor with an ki of 3.11 nM. PF-07321332 binds directly to the catalytic cysteine (Cys145) residue of the enzyme.
M10593 MRTX1133 MRTX1133 is a first-in-class, potent and highly selective KRAS G12D inhibitor. MRTX1133 targets the KRAS G12D protein in both active and inactive states. MRTX1133 selectively inhibits KRAS G12D mutant, but not KRAS wild-type, tumor cells.
M10592 Recombinant Human M-CSF (CHO-expressed) Macrophage-Colony Stimulating Factor (M-CSF), also known as Colony Stimulating Factor-1 (CSF-1), is a hematopoietic growth factor. It can stimulate the survival, proliferation and differentiation of mononuclear phagocytes, in addition to the spreading and motility of macrophages.
M10591 AZ304 AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF with IC50 values of 79 nM and 38 nM respectively.
M10590 Alofanib (RPT835) Alofanib (RPT835) is a novel selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect with IC50 <10 nM on FGF2-induced phoshphorylation of FRS2a in KATO III cells.
M10589 RGX-104 RGX-104, also known as SB 742881, is a liver X receptor beta (LXR) agonist with potential immunomodulating and antineoplastic activities.
M10588 Methyl syringate Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.
M10587 ML162 ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces ferroptosis, ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines.
M10586 JKE-1674 JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210. JKE-1674 reduces viability of LOX-IMVI cancer cells and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1.
M10585 WM-1119 WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM, Kd of 2 nM, WM-1119 is a reversible competitor of acetyl coenzyme A and inhibits MYST-catalysed histone acetylation.
M10584 SR17018 SR17018 is an mu-opioid-receptor (MOR) agonist, EC50 is 97 nM for binding with GTPγS.
M10583 RRX-001 RRx-001 is a hypoxia-selective epigenetic agent and studied as a radio- and chem-sensitizer, triggers apoptosis and overcomes dгυg resistance in myeloma. RRx-001 exhibits potent anti-tumor activity with minimal toxicity.
M10582 Rbin-1 Rbin-1 (ribozinoindole-1) is a potent and reversible inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family (GI50 value 136 nM in wild-type cells).
M10581 Trans-crocetin Trans-crocetin (Croceic Acid) is a blood-brain barrier-permeable NMDA receptor antagonist with high affinity, extracted from saffron (Crocus sativus L.). *The compound is unstable in solutions, freshly prepared is recommended
M10580 Guaiacol Guaiacol is a phenolic compound, which inhibits LPS-stimulated COX-2 expression and NF-κB activation, with anti-inflammatory activity.
M10579 Dinoprost tromethamine Dinoprost tromethamine (Prostaglandin F2α tromethamine) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist.
M10578 Flavone Flavone is an endogenous metabolite.

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