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Cat.No.  Name Information
M9002 ML281 ML-281 is a potent ans selective STK33 inhibitor with IC50 value of 14 nM.
M9001 ML-265 ML-265 (TEPP-46) is a potent and selective activator of recombinant pyruvate kinase M2 (PKM2).
M9000 ML-098 ML-098 is an activator of the GTP-binding protein Rab7 with EC50 value of 77.6 nM.
M8999 CCG-1423 CCG-1423 is a novel specific inhibitor of RhoA transcriptional signaling.
M8998 PIK-III PIK-III (also known as VPS34-IN2) is a potent and selective inhibitor of VPS34 enzymatic activity, with IC50s of 18 nM and 1.2 μM for VPS34 and PI(3)Kδ, respectively.
M8997 MK-1064 MK-1064 is a potent, selective and orally active Orexin OX2 Receptor Antagonist for the research of insomnia.
M8996 SAR-20347 SAR-20347 is a potent dual inhibitor of JAK1 and TYK2 with IC50 values of 23 and 0.6 nM, respectively.
M8995 THZ2 THZ2 (an analog of THZ1) is a potent and selective CDK7 inhibitor which overcomes the instability of THZ1 in vivo (IC50s: CDK7=13.9 nM; TNBC cells=10 nM).
M8994 AM095 free acid AM095 free acid is a potent LPA1 receptor antagonist which inhibited GTPγS binding to CHO cell membranes overexpressing recombinant human or mouse LPA1 with IC50 values of 0.98 and 0.73 μM, respectively.
M8993 BMS-986020 BMS-986020 (also known as AM152) is a potent and selective LPA1 antagonist.
M8992 AM966 AM966 is a potent, selective and orally active LPA(1) receptor antagonist which inhibits lung fibrosis in the mouse bleomycin model.
M8991 Dilmapimod Dilmapimod (also known as SB-681323 and GW-681323) is a p38 MAPK inhibitor that potentially suppresses inflammation in COPD.
M8990 LB-100 LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor, with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.
M8989 BIX-01294 BIX-01294 is a potent chemical inhibitor of G9a methyltransferase that catalyzes the mono-and di-methylation of the lysine 9 residue of histone H3, with IC50 of 1.9 μM.
M8988 PF-05089771 PF-05089771 is a selective Nav1.7 channel blocker that interacts with the voltage-sensor domain (VSD) of domain IV.
M8987 EMA401 EMA401 (also known as Olodanrigan and PD-126055) is a highly selective angiotensin AT2 antagonist.
M8986 CCX140 CCX140 is a potent CCR2 antagonist.
M8985 LY2828360 LY2828360 is a novel potent, selective, and efficacious CB2 cannabinoid agonist.
M8983 Compstatin Compstatinis is a 13-residue cyclic peptide, binds to complement component C3 and inhibits complement activation with IC50 of 12 μM.
M8982 Azaserine Azaserine is an inhibitor of the rate limiting step of the hexosamine biosynthethic pathway (HBP) and an irreversible inhibitor of GGT1 (gamma-Glutamyltranspeptidase).
M8981 Triadimenol Triadimenol (Triademenol) is a triazole-type fungicide that was identified as weak estrogen receptor agonists, Triademenol is reported as a potent exosome inhibitor which can block the activity of exosomes.
M8980 Neticonazole Hydrochloride Neticonazole Hydrochloride is an imidazole antifungal for the treatment of fungal skin infections, Neticonazole is reported as a potent exosome inhibitor which can block the activity of exosomes.
M8979 TM6008 TM6008 is a novel PHD inhibitor, which inhibited PHD and stabilized HIF activity in vitro.
M8978 3-TYP 3-TYP is a selective SIRT3 inhibitor, more potent over SIRT1 and SIRT2, with IC50 values of 88 nM, 92 nM, 16 nM for SITR1, SIRT2, SIRT3, respectively.
M8977 MK-4101 MK-4101 is a novel SMO antagonist of the Hedgehog Pathway.
M8976 ASP9521 ASP9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3).
M8975 CWHM-12 CWHM-12 is a potent inhibitor of αV integrins with IC50 values of 0.2, 0.8, 1.5, and 1.8 nM for αvβ8, αvβ3, αvβ6, and αvβ1, respectively.
M8974 ALW-II-41-27 ALW-II-41-27 is a Eph receptor tyrosine kinase inhibitor with an IC50 of 11 nM for EPHA2.
M8973 Fevipiprant Fevipiprant (QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.
M8972 BMS-626529 BMS-626529 is a potent HIV-1 attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells.
M8971 Grapiprant Grapiprant is a novel, potent and selective prostaglandin EP4 receptor antagonist with antihyperalgesic properties.
M8970 MLN120B MLN120B is a potent and effective, ATP competitive IKKβ inhibitor with IC50 value of 20 μM.
M8969 LY-3177833 LY-3177833 is a potent and selective inhibitor of CDC7 with IC50 of 3.3 nM.
M8968 FPS-ZM1 FPS-ZM1 is a high-affinity RAGE-specific blocker that inhibits amyloid-β binding to RAGE with a Ki of 25 nM.
M8967 Maytansinol Maytansinol, also known as Ansamitocin P-0, is a potent microtubule depolymerizing agent.
M8966 SB-649868 SB-649868 is a selective orally active orexin (OX) receptor antagonist with pKi values of 9.4 and 9.5 at the OX1 and OX2 receptor, respectively.
M8965 2,6-Diaminopurine 2,6-Diaminopurine is a compound used to treat leukemia.
M8964 Thymidine Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose.
M8963 JNJ-42041935 JNJ-42041935 is a potent, competitive, reversible, and selective inhibitor of PHD with pKi values of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09 for PHD1, PHD2, and PHD3, respectively.
M8962 Voruciclib Voruciclib (P1446A-05) is a protein kinase inhibitor specific for the cyclin-dependent kinase 4 (CDK4) with IC50s of 90nM, 25nM, and 22nM for CDK4-CyclinD1, CDK1-Cyclin B, and CDK9-Cyclin T, respectively.
M8961 LY2409881 trihydrochloride LY2409881 trihydrochloride is a potent and selective IKK2 inhibitor with IC50 of 30 nM.
M8960 LY2334737 LY2334737 is an orally available valproic acid ester of gemcitabine, a broad-spectrum antimetabolite with antineoplastic activity.
M8959 PD1-PDL1 inhibitor 1 PD1-PDL1 inhibitor 1 is an inhibitor of the PD-1 /PD-Ll protein/protein interaction with IC50 value of 6 nM.
M8958 Ivosidenib Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.
M8957 LH846 LH846 is a selective inhibitor of casein kinase with IC50 values of 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α, respectively.
M8956 Canagliflozin hemihydrate Canagliflozin hemihydrate (JNJ-28431754; TA 7284) is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM.
M8955 MIN-101 MIN-101 (Roluperidone) is a novel compound with affinities for 5-HT2A and sigma-2 receptors with Ki values of 7.53 nM and 8.19 nM, respectively.
M8954 Kobe2602 Kobe2602 is analog of Kobe0065, inhibits binding of H-Ras·GTP to c-Raf-1 with a Ki value of 149 ± 55 μM.
M8953 GDC-0810 GDC-0810 (Brilanestrant, ARN-81) is an orally bioavailable selective estrogen receptor degrader (SERD) with IC50 of 0.7 nM.
M8952 WS6 WS6 is a novel beta cell proliferation simulator, which promotes β cell proliferation in rodent and human primary islets with EC50 of 0.28 uM(R7T1 cell viability).
M8951 WEHI-345 WEHI-345 is a potent and selective RIPK2 inhibitor with IC50 of 0.13 μM.
M8950 JNJ-42165279 JNJ-42165279 is a potent and selective FAAH inhibitor with IC50s of 70 ± 8 nM and 313 ± 28 nM for hFAAH and rFAAH, respectively.
M8949 JI-101 JI-101 is an orally available multi-kinase inhibitor of VEGFR2,PDGFRβ and EphB4 with potential antiangiogenic and antineoplastic activities.
M8948 TUG-891 TUG-891 is a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120).
M8947 PF-01247324 PF-01247324 is a novel selective and orally bioavailable Nav 1.8 channel blocker with an IC50 of 196 nM for recombinant human Nav1.8 channel.
M8946 IQ-1S IQ-1S is a potent and selective JNK inhibitor with Kds of 100 nM, 240 nM, and 360 nM for JNK3, JNK1, and JNK2, respectively.
M8945 Defactinib hydrochloride Defactinib hydrochloride is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.
M8944 IDO-IN-1 IDO-IN-1 is a potent and selective indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50 of 59 nM.
M8943 GSK2981278 GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).
M8942 GSK163090 GSK163090 is a potent, selective, and orally active 5-HT1A/B/D receptor antagonist.
M8941 GDC-0853 GDC-0853 is an orally BTK inhibitor with potential antineoplastic activity.
M8940 GRA Ex-25 GRA Ex-25 is an inhibitor of glucagon receptor, with IC50 values of 56 and 55 nM for rat and human glucagon receptors, respectively.
M8939 Firategrast Firategrast (SB-683699) is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist.
M8938 FIIN-3 FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor with IC50 values of 13.1, 21, 31.4 and 35.3 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.
M8937 CPI-455 HCl CPI-455 HCl is a potent and selective inhibitor of KDM5 demethylases which reduces survival of drug-tolerant cancer cells, with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays.
M8936 FGFR4-IN-1 FGFR4-IN-1 is a potent and selective FGFR4 inhibitor with IC50 of 0.7 nM.
M8935 EXP-3174 EXP-3174 is a potent AT1 antagonist with Kis of 0.57 and 0.67 nM for rat and human forms, respectively.
M8934 ETC-159 ETC-159 is a potent, selective and orally available PORCN inhibitor, which inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
M8933 EPZ011989 EPZ011989 is a potent, orally-available EZH2 inhibitor with Ki < 3 nM for EZH2 wt and EZH2 Y646.
M8932 Eptapirone Eptapirone (F11440) is a potent 5HT(1A) receptor agonist with marked anxiolytic and antidepressant potential.
M8931 BI-7273 BI-7273 is a potent and selective BRD9 inhibitor with IC50s of 19 nM and 117 nM for BRD9 and BRD7, respectively.
M8930 EMD534085 EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC50 of 8 nM.
M8929 NAV-2729 NAV-2729 is a selective ARF6 inhibitor with IC50 value of 1.0 μM.
M8928 CEP-40783 CEP-40783 (RXDX-106) is a potent, selective and orally available inhibitor of AXL and c-Met with IC50 values of 7 nM and 12 nM, respectively.
M8927 VU-0155069 VU-0155069 is a potent and selective phospholipase D1 (PLD1) inhibitor.
M8926 Niraparib (MK-4827) tosylate Niraparib (MK-4827) tosylate is an excellent PARP1 and PARP2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively.
M8925 LY3023414 LY3023414 is a selective ATP-competitive inhibitor of PI3Kα and mTOR, DNA-PK, and other class I PI3K family members.
M8924 Daprodustat Daprodustat (GSK1278863) is a novel, orally active HIF-prolyl hydroxylase inhibitor.
M8923 CCG215022 CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50 values of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, GRK5 and GRK1, respectively.
M8922 Brevianamide F Brevianamide F belongs to a class of naturally occurring 2,5-diketopiperazines.
M8921 Bentamapimod Bentamapimod, also known as AS602801, is an ATP-competitive JNK inhibitor with IC50 of 80 nM, 90 nM, and 230 nM for JNK1, JNK2, and JNK3, respectively.
M8920 BDA-366 BDA-366 is a small molecule antagonist that specifically binds the BCL2 BH4 domain, and has the ability to convert anti-apoptotic BCL2 into a pro-apoptotic death molecule.
M8919 BAY 59-3074 BAY-59-3074 is a novel cannabinoid CB1/CB2 receptor partial agonist with Ki values of 48.3 and 45.5 nM at human CB1 and CB2 receptors, respectively.
M8918 BAY 1217389 BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM.
M8917 BAW2881 BAW2881 (NVP-BAW2881) is a potent and selective VEGFR2 inhibitor with activity to inhibit chronic and acute skin inflammation.
M8916 SU1498 SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM).
M8915 TP-0903 TP-0903 is a potent and selective AXL inhibitor with an IC50 value of 27 nM.
M8914 AZD6738 AZD6738 is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM.
M8913 Telotristat ethyl Telotristat ethyl, also known as LX1606, is an oral serotonin synthesis inhibitor or peripheral tryptophan hydroxylase (TPH) inhibitor.
M8912 ML-18 ML18 is Bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM).
M8911 GS967 GS967, also known as GS-458967, is a potent and selective blocker of cardiac late sodium current (late INa) with IC50 values of 0.13 and 0.21 μM for ventricular myocytes and isolated hearts, respectively.
M8910 Pamapimod Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor, inhibited p38alpha and p38beta enzymatic activity, with IC50 values of 0.014 +/- 0.002 and 0.48 +/- 0.04 microM, respectively.
M8909 Miransertib Miransertib, also known as ARQ 092, is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3).
M8908 ASC-J9 ASC-J9, also known as GO-Y025 and Dimethylcurcumin, suppressesing castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors.
M8907 Acecainide HCl Acecainide HCl, also known as N-acetylprocainamide and ASL 601, is the N-acetylated metabolite of procainamide.
M8906 Sematilide hydrochloride Sematilide (CK-1752) hydrochloride is a novel class III antiarrhythmic agent.
M8905 EBE-A22 EBE-A22 is a derivative of PD 153035, has no effect on EGF-R TK but maintains a high cytotoxic profile.
M8904 NIH-12848 NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor.
M8903 SR-3029 SR-3029 is a potent and ATP competitive CK1δ and CK1ε inhibitor, with IC50s of 44 nM and 260 nM, respectively.
M8902 CVT-313 CVT-313 is a potent and selective inhibitor of CDK2 that prevents neointimal proliferation, which has an IC50 of 0.5 microM in vitro.


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