Cat.No. | Name | Information |
---|---|---|
M54744 | Dihydroferulic acid | Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC50 value of 19.5 μM. Dihydroferulic acid (Hydroferulic acid) is a metabolite of human gut microflora as well as a precursor of vanillic acid. |
M54743 | 4-Isopropylbenzoic acid | 4-Isopropylbenzoic acid is an aromatic monoterpenoid isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid shows antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive mushroom tyrosinase inhibitor. |
M54742 | Leaf alcohol | Leaf alcohol (Cis-3-Hexen-1-ol) is an aroma compound which typically described as "green grassy" or the smell of "cut grass". Cis-3-Hexen-1-ol has been found in many fresh fruits and vegetables and widely used as an added flavor in processed food and perfume. Cis-3-Hexen-1-ol is also an attractant to various insects. |
M54741 | 3-Amino-2-piperidinone | 3-Amino-2-piperidinone is a metabolite from all living organisms and can be used as a cyclic ornithine analogue. |
M54740 | 6-Methoxynaringenin | 6-Methoxynaringenin is an aerial part of Scutellaria barbata D. Don (Lamiaceae) and inhibits NO production efficiently with an IC50 value of 25.8 μM. |
M54739 | Recombinant Human ICA 512/PTPRN Protein (80AA&94AA, E.coli, N-6His) | ICA 512/PTPRN Protein belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. ICA 512/PTPRN implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. |
M54738 | Recombinant Human ICA 512/PTPRN Protein (293AA, E.coli, N-6His) | ICA 512/PTPRN Protein belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. ICA 512/PTPRN implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. |
M54737 | Recombinant Human GAD67 Protein (Baculovirus-Insect, C-His) | GAD67 (GAD1) is a member of thegroup II decarboxylase family. GAD67 is expressed in benign and malignant prostatic tissue and may serve as a highly prostate-specific tissue biomarker. |
M54736 | hFSH-β-(33-53) TFA | hFSH-β-(33-53) TFA, a thiol-containing peptide which corresponds to a second FSH receptor-binding domain, is a FSHR (follicle-stimulating hormone receptor) antagonist. hFSH-β-(33-53) TFA inhibits binding of FSH to receptor and is a partial agonist of estradiol synthesis in Sertoli cells. |
M54734 | SLK/STK10-IN-1 | SLK/STK10-IN-1 is a potent and selective inhibitor of SLK and STK10 with nanomolar potency. |
M54732 | Recombinant Human GAS6 Protein (Mammalian, C-6His) | GAS6 (Growth arrest-specific protein 6) also known as AXL receptor tyrosine kinase ligand, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. |
M54731 | Recombinant Mouse GAS6 Protein (HEK293, C-His) | GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. |
M54730 | INV-347 | INV-347 is a CB1R inverse agonist that can be used in studies related to obesity. |
M54728 | Kdo2-Lipid A ammonium | Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxic activity equivalent to LPS.Kdo2-Lipid A ammonium is highly selective for TLR4 and stimulates the release of TNF and PGE2. |
M54727 | Xylan | Xylan is a polypentasaccharide and a hemicellulose component found extensively in plant cell walls.Xylan consists mainly of cellulose-linked β-D-xylose units. |
M54726 | Chitosan (MW 150000) | Chitosan (MW 150000) is a polycationic linear polysaccharide derived from chitin with a molecular weight of 150000.Chitosan is non-toxic, hypoallergenic, biocompatible, biodegradable, and possesses anti-tumor, anti-bacterial, anti-fungal, and anti-oxidant activities.Chitosan can be used in studies related to drug delivery and cell transfection. |
M54725 | Chitosan (MW 30000) | Chitosan (MW 30000) is a polycationic linear polysaccharide derived from chitin with a molecular weight of 30,000.Chitosan is non-toxic, hypoallergenic, biocompatible, biodegradable, and possesses anti-tumor, anti-bacterial, anti-fungal, and antioxidant activities.Chitosan can be used in studies related to drug delivery and cell transfection. |
M54724 | Trimethylamine N-oxide dihydrate | Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients.Trimethylamine N-oxide dihydrate induces inflammation by activating ROS/NLRP3 inflammasome, and also accelerates fibroblast differentiation and induces cardiac fibrosis by activating TGF-β/smad2 signaling pathway. In addition, Trimethylamine N-oxide dihydrate induces tumor cell pyroptosis and enhances CD8+ T cell-mediated antitumor responses in triple-negative breast cancer. |
M54722 | Fluoflavine | Fluoflavine is a selective NOX1 inhibitor with an IC50 value of 90 nM.Fluoflavine is >100 times more selective for NOX1 than NOX2, NOX3, NOX4, and has an IC50 >10 μM for all of them.Fluoflavine was shown to be a selective inhibitor of NOX1 with an IC50 of 360 nM in HEK293 cells. |
M54721 | A 83-01 sodium | A 83-01 sodium is a potent inhibitor of TGF-β type I receptors ALK5, ALK4, and ALK7, inhibiting ALK5, ALK4, and ALK7-induced transcription with IC50 values of 12 nM, 45 nM, and 7.5 nM, respectively. |
M54719 | O4I3 | O4I3 is a potent and selective inhibitor of the KDM5A (JARID1A) isoform of H3K4 demethylase, with an IC50 value of 0.15 nM.O4I3 effectively induces OCT4 expression and enhances OSKM-induced pluripotent stem cell reprogramming efficiency (50 nM) of human primary fibroblasts by preventing KDM5A from interfering with the enrichment of H3K4Me3 on the OCT4 promoter. iPSC) reprogramming efficiency (50 nM). |
M54718 | PP405 | PP405 is a potent localized mitochondrial pyruvate carrier (MPC) inhibitor that acts on cellular metabolic pathways to up-regulate LDH and activate stem cells to promote hair growth, and can be used in studies related to androgenetic alopecia. |
M54717 | GYM329 | GYM329 is a monoclonal antibody that binds to and inhibits activation of the muscle growth inhibitor (myostatin) precursor protein target. |
M54716 | Trontinemab | Trontinemab is a bispecific human IgG1-κ antibody that targets amyloid β A4 precursor protein (APP) and transferrin receptor (TFRC).Trontinemab may be used in Alzheimer's disease-related studies. |
M54715 | ZK53 | ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP), with EC50 of 1.37 μM for α-casein hydrolysis by HsClpP. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. |
M54714 | BAY 1892005 | BAY 1892005, a p53 protein modulator, is active on p53 condensates and does not lead to mutant p53 reactivation. |
M54713 | ZH8667 | ZH8667 is a trace amine-associated receptor 1 (TAAR1)–Gs agonist. |
M54712 | PF-07224826 | PF-07224826 is a CDK2/4/6 inhibitor. |
M54711 | INCB123667 | INCB123667 is a CDK2 inhibitor. |
M54710 | Senexin B | Senexin B is a potent, orally active CDK8/19 inhibitor with Kd values of 140 nM and 80 nM for CDK8 and CDK19, respectively. |
M54709 | Q901 | Q901 is a CDK7 inhibitor for tumor-related studies. |
M54708 | NUV-422 | NUV-422 is a CDK2/4/6 inhibitor that can be used in studies related to malignant gliomas. |
M54707 | INX-315 | INX-315 is an orally potent and selective CDK2 inhibitor that induces cell cycle arrest in G1 phase. INX-315 also induces CDK2 substrate phosphorylation and inhibits tumor growth in a dose-dependent manner in a xenograft mouse model.INX-315 can be used in cancer-related studies. |
M54706 | GTAEXS-617 | GTAEXS-617 is a highly selective small molecule non-covalent CDK7 inhibitor. |
M54705 | BLU-222 | BLU-222 is an oral, potent, selective CDK2 inhibitor. |
M54704 | AZD-8421 | AZD-8421 can target CDK2 and can be used in tumor-related studies. |
M54703 | BBT-207 | BBT-207 is a reversible, mutant-specific EGFR inhibitor with antitumor activity. |
M54702 | VRN-11 | VRN-11 is an EGFR C797S inhibitor. |
M54701 | TRX-221 | TRX-221 is an EGFR C797S inhibitor. |
M54700 | TAS-3351 | TAS-3351 is an EGFR C797S inhibitor. |
M54699 | Recombinant Human Lactoferrin/LTF Protein (Mammalian, C-6His) | Lactoferrin (LTF) is a major iron-binding protein in exocrine fluid and controls the level of free iron in the blood and external secretions. It exhibits multiple antibacterial effects by chelating iron and disrupting bacterial membranes. |
M54698 | LY-3076226 | LY-3076226 is an antibody drug coupling (ADC) with a cleavable linker targeting FGFR2. |
M54697 | Aprutumab ixadotin | Aprutumab ixadotin is an antibody drug coupling (ADC) with a non-cleavable linker that targets FGFR2. |
M54696 | DGY-09-192 | DGY-09-192 is a bivalent degrader that couples the pan-FGFR inhibitor BGJ398 to the CRL2VHL E3 ligase-recruiting ligand, which induces degradation of FGFR1/2 and largely avoids degradation of FGFR3/4.DGY-09-192 exhibits a nanomolar DC50 against both wild-type FGFR2 and several FGFR2 fusions. In addition, DGY-09-192 has antiproliferative activity in gastric and cholangiocarcinoma cells. |
M54695 | Kendomycin | Kendomycin is a polyketide antibiotic with significant antibacterial activity and tumor cytotoxicity. At low concentrations (MIC: 5 μg/mL), Kendomycin inhibits the growth of methicillin-resistant Staphylococcus aureus (MRSA) strain COL. In addition, Kendomycin is an endothelin receptor antagonist and calcitonin receptor agonist. |
M54693 | Ceftobiprole | Ceftobiprole is a broad-spectrum cephalosporin with rapid bactericidal activity against Gram-positive bacteria such as Staphylococcus aureus, including methicillin-resistant strains (MRSA), and Gram-negative bacteria, with a MIC90 value of 2 μg/mL against MRSA. |
M54692 | MM120 | MM120 is a synthetic tryptamine that is also a partial agonist at the 5-hydroxytryptamine 2A (5-HT2A) receptor. It can be used in studies related to GAD and attention deficit hyperactivity disorder (ADHD). |
M54691 | Leuco methylthioninium | Leuco methylthioninium is a tau protein aggregation inhibitor that can be used in studies related to Alzheimer's disease (AD). |
M54690 | HB0017 | HB0017 is a monoclonal antibody that targets interleukin-17 (IL-17) and selectively binds IL-17A, thereby preventing IL-1717A from binding to its receptor. |
M54689 | Astragalus Polysacharin (70%) | Astragalus Polysacharin is a natural product from Astragalus membranaeus, used as adjuvant, attenuates TNF-α-induced insulin resistance by suppressing miR-721 and activating PPAR-γ and PI3K/Akt in 3T3-L1 adipocytes. |
M54688 | Pegtibatinase | Pegtibatinase is a cystathionine beta synthase (CBS) regulator that can be used in studies related to homocystinuria. |
M54687 | SQLE-IN-1 | SQLE-IN-1 is a squalene cyclooxygenase (SQLE) inhibitor and inhibits the proliferation and migration of Huh7 cells. In addition, SQLE-IN-1 inhibits cellular cholesterol production, increases PTEN expression, and inhibits PI3K and AKT expression. |
M54686 | Amycretin | Amycretin is a novel, potentially first-in-class, long-acting co-agonist of GLP-1 and the amyloid receptor (AMYR) for obesity-related studies. |
M54685 | IRAK4-IN-22 | IRAK4-IN-22 is an orally potent and selective potent IRAK4 inhibitor with IC50 values of 3 and 17 nM for IRAK4 and TAK1, respectively.In addition, IRAK4-IN-21 potently inhibits the production of IL-23 (IC50=0.10 µM), which may be useful in studies related to autoimmune diseases such as plaque psoriasis and psoriasis vulgaris. arthritis). |
M54684 | HS271 | HS271 is an orally potent and selective IRAK4 inhibitor with an IC50 value of 7.2 μM. In addition, HS271 has superior in vitro enzymatic and cellular activities. |
M54683 | PROTAC IRAK4 degrader-3 | PROTAC IRAK4 degrader-3 is a von Hippel-Lindau based IRAK4 degrader PROTAC. |
M54682 | IRAK inhibitor 4 (trans) | IRAK inhibitor 4 (trans) is the trans form of IRAK inhibitor 4 and a potent inhibitor of IRAK4. |
M54681 | IRAK4-IN-21 | IRAK4-IN-21 is an orally potent, selective, and potent IRAK4 inhibitor with IC50 values of 5 and 56 nM for IRAK4 and TAK1, respectively.IRAK4-IN-21 potently inhibits the production of IL-23 (IC50=0.17 µM) and may be useful in studies related to autoimmune diseases such as plaque psoriasis and psoriasis vulgaris. arthritis). |
M54680 | Larotinib mesylate hydrate | Larotinib mesylate hydrate is a potent, broad-spectrum, orally active tyrosine kinase inhibitor (TKI) that primarily targets EGFR with an IC50 of 0.6 nM. |
M54679 | IRAK-4 protein kinase inhibitor 2 | IRAK-4 protein kinase inhibitor 2 is a potent interleukin 1 (IL-1) receptor-associated kinase 4 (IRAK-4) inhibitor with an IC50 value of 4 μM.IRAK-4 protein kinase inhibitor 2 can be used in the study of inflammatory and immune-related diseases. |
M54678 | KTX-582 | KTX-582 is a potent IRAK4 degrader with a DC50 of 4 nM and 5 nM for IRAK4 and Ikaros, respectively.In addition, KTX-582 induces apoptosis in MYD88MT DLBCL cells and tumor regression in vivo in a lymphoma model. |
M54677 | KTX-951 | KTX-951 is a PROTAC (DC50= 18 nM) that targets the degradation of interleukin-1 receptor-associated kinase 4 (IRAK4) and exhibits promising anticancer activity. |
M54676 | PF-06426779 | PF-06426779 is a potent and selective inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) with an IC50 value of 0.3 nM. |
M54675 | Edecesertib | Edecesertib is a selective, orally active IRAK-4 inhibitor. In addition, Edecesertib has anti-inflammatory activity and may be used in studies related to rheumatoid arthritis (RA) and lupus erythematosus (LE). |
M54674 | IRAK inhibitor 2 | IRAK inhibitor 2 is an interleukin-1 receptor-related kinase 4 (IRAK4) inhibitor. |
M54673 | JH-X-119-01 hydrochloride | JH-X-119-01 hydrochloride is a potent and selective inhibitor of interleukin 1 receptor-associated kinase 1 (IRAK1), which also ameliorates LPS-induced sepsis in mice. |
M54672 | Bovine Serum Albumin (Fatty Acid & IgG Free) | BSA is a highly purified, lyophilized albumin, suitable for Westerns, enzyme systems, protein standards, hybridizations and as a protease-sensitive immunoassays. It is also perfectly suitable as a nutrient in cell culture media, with low interference and backgrounds and is ideal for most standard molecular biology experiments. |
M54671 | BTX-6654 | BTX-6654 is a targeted and specific cerebellar-based bifunctional SOS1 PROTAC degrader.BTX-6654 reduces the downstream signaling markers pERK and pS6 and displays antiproliferative activity in a wide range of KRAS-mutant cells. |
M54670 | JTE-151 | JTE-151 is a RORγ inhibitor that suppresses overactive immune responses by inhibiting RORγ associated with Th17 cell activation.JTE-151 can be used in studies related to autoimmune diseases. |
M54669 | TL-925 | TL-925 is a potentially first-in-class Bruton's tyrosine kinase (BTK) inhibitor that targets mast cell-mediated ocular inflammation and hypersensitivity and can be used in studies related to dry eye. |
M54668 | A-005 | A-005 is a potentially first-in-class, brain-penetrating TYK2 allosteric inhibitor for studies related to neuroinflammatory and neurodegenerative diseases. |
M54667 | UCCF-853 | UCCF-853 is a cystic fibrosis transmembrane regulatory protein (CFTR) modulator. |
M54666 | (R)-Posenacaftor sodium | (R)-Posenacaftor sodium is the R-enantiomer of Posenacaftor and a cystic fibrosis transmembrane regulatory protein (CFTR) modulator that corrects the folding and transport of CFTR proteins.Posenacaftor is used in studies related to cystic fibrosis (CF). |
M54664 | (R)-Olacaftor | (R)-Olacaftor is a cystic fibrosis transmembrane regulator (CFTR) modulator that can be used in cystic fibrosis (CF) related studies. |
M54662 | CFTR corrector 9 | CFTR corrector 9 is a cystic fibrosis transmembrane conductance regulator protein (CFTR) modulator for cystic fibrosis (CF) and other CFTR-related diseases. |
M54661 | CFTR corrector 8 | CFTR corrector 8 is a potent modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and can be used in cystic fibrosis related studies. |
M54660 | VRT-532 | VRT-532 is a potent modulator of cystic fibrosis transmembrane conductance regulator (CFTR) that enhances channel activity in G551D-CFTR and intrinsic ATPase activity in G551D-CFTR.VRT-532 can be used in cystic fibrosis related studies. |
M54659 | (R)-Elexacaftor | (R)-Elexacaftor is an enantiomer of Elexacaftor and a corrector of cystic fibrosis transmembrane conductance regulator (CFTR) with an EC50 value of 0.29 μM for CFTR dF508. |
M54658 | Ivacaftor hydrate | Ivacaftor hydrate is an orally active cystic fibrosis transmembrane conductance regulator (CFTR) enhancer for cystic fibrosis related studies. |
M54657 | CFTR corrector 6 | CFTR corrector 6 is a potent cystic fibrosis transmembrane conductance regulator (CFTR) enhancer for cystic fibrosis (CF) and other CFTR-related diseases. |
M54656 | NJH-2-056 | NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking EN523, a recruitment factor for OTUB1, to lumacaftor, a CFTR chaperone protein.NJH-2-056 can be used in cystic fibrosis-related studies. |
M54655 | K41498 TFA | K41498 TFA is an antisauvagine-30 (aSvg-30) analog and a strongly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM, and 425 nM for human CRF2α, CRF2β, and CRF1 receptors, respectively.K41498 TFA inhibits sauvagine-stimulated cAMP accumulation in hCRF2α/hCRF2β expressing cells. K41498 TFA can be used in hypotension studies. |
M54654 | Crinecerfont hydrochloride | Crinecerfont hydrochloride is a potent, orally active, nonpeptide CRF1 receptor antagonist for use in congenital adrenal hyperplasia (CAH) studies. In addition, Crinecerfont hydrochloride is a click chemistry. It contains an Alkyne moiety that undergoes a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an Azide moiety. |
M54653 | SRI-37240 | SRI-37240 is a potent inhibitor of premature termination codons (PTCs) that suppresses nonsense mutations in CFTR. In HEK293T cells, SRI-37240 alters the cellular translation termination of PTCs. When used in combination with G418, SRI-37240 also restores CFTR function in primary bronchial epithelial cells. |
M54652 | Bamocaftor | Bamocaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector that restores F508del-CFTR protein function.Bamocaftor can be used in cystic fibrosis-related studies. |
M54651 | Cavosonstat | Cavosonstat is an orally active nitrosoglutathione reductase (GSNOR) inhibitor. In addition, Cavosonstat is a CFTR stabilizer and can be used in cystic fibrosis studies. |
M54649 | Navocaftor | Navocaftor is a cystic fibrosis transmembrane regulator (CFTR) modulator. |
M54648 | SRI-41315 | SRI-41315 inhibits PTCs (premature termination codons) associated with cystic fibrosis in permanent and primary human bronchial epithelial cells by inducing a prolonged stoppage of the termination codon, restoring the expression and function of cystic fibrosis transmembrane conductance regulator (CFTR). In addition, SRI-41315 enhances aminoglycoside-mediated passaging, leading to a synergistic increase in CFTR activity. |
M54647 | (R)-Vanzacaftor | (R)-Vanzacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). |
M54646 | Astressin 2B TFA | Astressin 2B TFA is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist with IC50 values of 1.3 and > 500 nM for CRF2 and CRF1, respectively. |
M54645 | SION-109 | SION-109 is a transmembrane conductance regulator (CFTR) modulator that targets the interface of CFTR nucleotide-binding domain 1 (NBD1) interaction with the CFTR intracellular loop 4 (ICL4) protein domain. |
M54644 | SION-719 | SION-719 is a potentially first-in-class transmembrane conductance regulator (CFTR) modulator that stabilizes nucleotide-binding domain 1 (NBD1) of CFTR protein. |
M54643 | SION-451 | SION-451 is a potentially first-in-class transmembrane conductance regulator (CFTR) modulator that stabilizes nucleotide-binding domain 1 (NBD1) of CFTR protein. |
M54642 | Scalaradial | Scalaradial is a marine-derived natural product that modulates protein tyrosine kinase receptor-mediated signaling pathways. |
M54641 | Murrayafoline A | Murrayafoline A is a carbazole alkaloid that enhances calcium inward flow through L-type calcium channels.Murrayafoline A can be used for related research in the life sciences. |
M54640 | Showdomycin | Showdomycin is an antibiotic that is induced by IM-2 in Streptomyces. |
M54639 | Shizukaol A | Shizukaol A is a sesquiterpene dimerizable from Chloranthus japonicas. |
M54638 | Aspulvinone O | Aspulvinone O is a natural inhibitor of aspartate aminotransferase 1 (GOT1) and inhibits the growth of pancreatic ductal adenocarcinoma cells by interfering with glutamine metabolism. |
M54637 | Recombinant Mouse Thioredoxin/SASP Protein (E. coli) | Thioredoxin/SASP Protein participates in a variety of redox reactions and can use its active dithiol center for reversible oxidation and disulfide bond formation. It catalyzes important dithiol-disulfide exchanges and plays a key role in the S-nitrosylation of cysteine residues in response to intracellular nitric oxide. |
M54636 | Recombinant Human Thioredoxin/SASP Protein (E.coli, N-6His) | Recombinant Human Thioredoxin/SASP Protein participates in a variety of redox reactions and can use its active dithiol center for reversible oxidation and disulfide bond formation. It catalyzes important dithiol-disulfide exchanges and plays a key role in the S-nitrosylation of cysteine residues in response to intracellular nitric oxide. |
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