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Cat.No.  Name Information
M13386 Myxothiazol Myxothiazol, an antifungal antibiotic, is an inhibitor of mitochondrial electron transport chain complex III (Complex III or Bc1 complex).
M13385 WGA Wheat agglutinin (WGA) is isolated from wheat (Triticum vulgaris, Weat germ), WGA selectively binds to glycoproteins and glycolipids of n-acetylglucosamine (GlcNAc) and n-acetylneuraminine (sialic acid) residues.
M13384 Kira8 Kira8 (AMG-18) is a single selective IRE1α inhibitor with an IC50 of 5.9 nM.
M13383 (Rac)-Indoximod (Rac)-Indoximod(1-methyl-DL-tryptophan) is an indoleamine 2, 3-dioxygenase (IDO) inhibitor.
M13382 LY-3381916 LY-3381916 (IDO1-IN-5) is a potent IDO1 inhibitor that can penetrate the blood brain barrier. LY-3381916 May show antitumor activity.
M13381 Pyridoclax Pyridoclax is a potential McL-1 inhibitor.
M13380 Tapotoclax Tapotoclax is an inhibitor of myeloid leukemia cell differentiation protein McL-1 (myeloid leukemia-1) with a Ki value of 0.13 nM and has potential pro-apoptotic and anti-tumor activity.
M13379 Guggulsterone Guggulsterone is a plant sterol from the gum fat of the Commiphora Wightii tree. It occurs in two heterogeneous forms, namely z-GS and E-GS.
M13378 Antide Sequence:Ac-D2Nal-DCpa-DPal-Ser-Lys(nicotinoyl)-DLys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-DAla-NH2
M13376 Abarelix Abarelix (R3827) is the first approved antagonist for the study of GnRH in advanced prostate cancer. Sequence:Ac-{d-2-Nal}-{d-4-Cpa}-{d-3-Pal}-S-{NMyr}-{d-Asp}-L-K(ipr)-P-{d-Ala}-NH2
M13375 Cetrorelix Sequence:Ac-D2Nal-D4Cpa-D3Pal-Ser-Tyr-DCit-Leu-Arg-Pro-DAla-NH2
M13374 Ganirelix Sequence: Ac-D-2-Nal-D-Phe(4-Cl)-D-3-Pal-Ser-Tyr-D-Lys(C(NHEt)2)-Leu-Lys(C(NHEt)2)-Pro-D-Ala-NH2
M13373 Sobetirome Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ) agonist. Sobetirome selectively binds to TRβ-1 with an EC50 of 0.16 μM.
M13372 Brincidofovir Brincidofovir (CMX001), a lipid-coupled precursor compound of Cidofovir (HY-17438), has long-lasting antiviral effects and is active against a wide range of DNA viruses. These include cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomavirus, papillomavirus, poxvirus, and mixed double-stranded DNA virus infections.
M13371 Onametostat (JNJ-64619178) Onametostat (JNJ-64619178) is a pseudo-irreversible, orally active, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.14 nM. Good pharmacokinetic properties and safety.
M13370 KML-29 KML29 is an effective selective MAGL inhibitor with IC50 values of 15 nM, 43 nM and 5.9 nM in mice, rats and humans, respectively. KML29 has minimal cross-reaction with other central and peripheral serine hydrolases including FAAH.
M13369 ABX-1431 ABX-1431 is a highly potent, selective and orally available CNS-osmotic monacylglycerol lipase (MAGL) inhibitor with IC50 values of 14 nM and 27 nM against human and mouse MGLL, respectively.
M13368 IMT1B IMT1B (LDC203974) is a highly specific human mitochondrial RNA polymerase (POLRMT) inhibitor that inhibits mitochondrial DNA (mtDNA) expression. IMT1B has antitumor effects.
M13367 Metarrestin (ML246) Metarrestin (ML246) is an orally active, specific inhibitor of Perinucleolar compartment (PNC) that destroys nucleolar structure and inhibits RNA Polymerase (Pol) I transcription. Metarrestin blocked the progression of metastasis in mouse cancer models and extended survival.
M13366 (R)-MG-132 (R)-MG-132 (Z-LEu-LEu-Al) is a cellular permeable proteasome and Calpain inhibitor with IC50 of 100 nM and 1.2 μM, respectively.
M13365 Nonapeptide-1 acetate salt Nonapeptide-1 acetate salt is apeptide hormone, which is a potent antagonist of α -melanocyte-stimulating hormone (α-MSH) with an IC50 value of 11 nM.
M13364 Tricyclazole Tricyclazole is a biosynthetic inhibitor of pentaketone melanin and a unique fungicide for rice blast control.
M13363 CCG-222740 CCG-222740 is an inhibitor of the Rho/MRTF pathway. CCG-222740 is also an effective α -smooth muscle actin protein expression inhibitor. CCG-222740 effectively reduces skin fibrosis and prevents melanoma metastasis.
M13362 ASP4132 ASP4132 is an orally active, potent AMPK activator with an EC50 of 18 nM and anticancer activity that promotes tumor regression in a xenograft mouse model of breast cancer.
M13361 MK8722 Mk-8722 is a potent, direct, PAN-AMPK allosteric activator.
M13360 Serotonin Serotonin is a monoamine neurotransmitter and endogenous 5-HT receptor agonist in CNS. Serotonin is also an inhibitor of catechin-o-methyltransferase (COMT) with a Ki value of 44 μM. Serotonin is also a natural product of animals.
M13359 GSK963 GSK963 is a chiral small-molecule inhibitor of RIP1 kinase (RIPK1) with an IC50 value of 29 nM. GSK963 has strong and selective inhibitory effect on the necrosis of mouse and human cells in vitro.
M13358 GSK-843 GSK-843 is a potent ATP-competitive RIP3 (RIPK3) kinase inhibitor (IC50 = 6.5 nM) that inhibits TNF/Z-VAD-FMK/IAP agonist-induced cell necrosis in human mice (EC50 range <0.12 to 3 μM).
M13357 EOC317 EOC317 (ACTB-1003) is an orally available kinase inhibitor that inhibits FGFR1, VEGFR2, and tie-2 with IC50 values of 6,2, and 4 nM, respectively.
M13356 SKI-178 SKI-178 is a potent sphingosine kinase-1 (SphK1) and SphK2 inhibitor. In acute myeloid leukemia (AML) cell lines, the IC50 range is about 500 nm-1 μM. Ski-178 induces apoptosis of human acute myeloid leukemia cells in a CDK1-dependent manner.
M13355 MP-A08 Mp-a08 is a highly selective inhibitor of ATP-competitive sphingine kinase (SPHK1) with Ki value of 6.9 μM.
M13354 Angiopep-2 TFA Angiopep-2 TFA is a brain peptide carrier. Binding of the antitumor compound to angiopEP-2 peptide carrier enhances its activity in brain cancer. Amino acid serial sequence: Thr-Phe-Phe-Tyr- GLly - Glly -Ser-Arg- GLly -Lys-Arg-Asn-Asn-Phe-Lys-Thr- glu-glu-TYr
M13353 Phosphatidylcholines,soya Phosphatidylcholines, soya is a kind of extracted from soybean phosphatidyl choline, can be used for the preparation of liposomes. Has been shown to play important roles in many important areas, including maintenance of cellular structure, fat metabolism, memory, nerve signaling, acting as a precursor of important neurotransmitters, and liver health. Phosphatidylcholines, soya can be used as animal drug delivery carrier.
M13352 Hetrombopag Hetrombopag is an effective thrombopoietin receptor agonist. Hetrombopag is effective, well tolerated and has a controllable safety profile. Hetrombopag has the potential to be studied in immune thrombocytopenia.
M13351 DSPE-PEG(2000)-MAL DSPE-PEG-MAL is one of the reactive phospholipid PEG reagents that can react with sulfhydryl group (mercaptan, -SH). DSPE (1, 2-distearyl-Sn-glycerol 3-phosphate ethanolamine) is a highly hydrophobic saturated 18C phospholipid.
M13350 7-Ketolithocholic acid 7-ketolithocholic acid (3α -hydroxy-7-oxo-5 β-cholanic acid) is a derivative of cholcholic acid, which can be absorbed to inhibit endogenous bile acid production and bile cholesterol secretion. Cholic acid is also used as a cholic acid derivative of TGR5 regulators.
M13349 Tebipenem Tebipenem, the first oral carbapenem antibiotic, inhibits both gram-positive and gram-negative bacteria, but has no effect on Pseudomonas aeruginosa.
M13348 LyP-1 TFA Lyp-1 TFA is a circular 9-amino acid tumor-targeting peptide that selectively binds its P32 receptor protein in a variety of tumor-associated cells.
M13347 FR901464 FR901464 is an effective spliceosome inhibitor with significant antitumor and anticancer effects.
M13346 Taurodeoxycholate sodium salt Taurodeoxycholate sodium salt is a bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. It is used as a cholagogue and choleretic, also industrially as a fat emulsifier.
M13345 LE135 LE135 is an effective RAR antagonist, which can selectively bind RARα (Ki is 1.4 μM) and RARβ (Ki is 220 nM), and has a higher affinity for RARβ. The LE135 is highly selective for RARγ, RXRα, RXRβ and RXRγ. LE135 is also a vitamin A acid receptor antagonist.
M13344 Tidiacic Tidiacic acid, a carboxylic acid derivative, can be used as pharmaceutical intermediates.
M13343 Trichloroacetic acid Trichloroacetic acid (TCA) is derived from trichloroethylene (TCE) metabolism. It can be used as an acid decalcifier. Trichloroacetic acid, a metabolite of Trichloroacetic acid, is believed to contribute to its liver cancer effect in mice.
M13342 DSG Crosslinker DSG Crosslinker is a cleavable ADC linker that can be used to synthesize antibody-conjugated drugs (ADCs).
M13341 VTP50469 VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL Interaction with a Ki value of 104 pM. VTP50469 has anti-leukemia activity.
M13340 Uric acid Uric acid is a scavenger of oxygen radical, a very important antioxidant and a product of the metabolic decomposition of purine nucleotides. Helps maintain stable blood pressure and fights oxidative stress. Uric acid removes reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite and inhibits lipid peroxidation.
M13339 L-Palmitoylcarnitine L-palmitoyl carnitine is a long-chain acylcarnitine and fatty acid metabolite that accumulates in the sarcoid during ischemia and disrupts the membrane lipid environment. L-palmitoylcarnitine inhibits KATP channel activity by interacting with Kir6.2 without affecting single channel conductance.
M13338 Trimethylamine N-oxide Trimethylamine n-oxide is a microbiome dependent metabolite of dietary choline and other Trimethylamine nutrients. It belongs to the amine oxide class. Trimethylamine n-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine n-oxide also accelerates fibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway.
M11556 NLG-919 (Navoximod) Navoximod (GDC-0919; Nlg-919) is an effective IDO (indoleamine-(2,3)-dioxygenase) inhibitor with Ki/EC50 of 7 nM/75 nM respectively.
M11555 Relacorilant Relacorilant is a selective, oral bioeffective glucocorticoid receptor antagonist (Ki of 7.2 nM in HepG2 TAT assay and 12,81.2 nM in rat, human and monkey glucocorticoid receptor in cell-based assay). Relacorilant can be used in studies of Cushing's syndrome.
M11554 Pristane Pristane (Norphytane) is a naturally saturated terpene alkane found in small amounts in many plants, various Marine organisms, and is the most active component in mineral oils. Pristane is a non-antigenic adjuvant that induces MHC Class II restrictive arthritis T cells in rats.
M11553 WS3 WS3 is a β cell proliferation inducer, which can promote the β cell proliferation of primary rat and human islets. WS3 can be used in the study of type I diabetes.
M11552 DREADD agonist 21 DREADD Agonist 21 is an effective agonist for human muscarinic acetylcholine M3 receptor (hM3Dq) (EC50=1.7 nM).
M11551 Deschloroclozapine Deschloroclozapine is an effective, high affinity, selective, metabolically stable agonist based on muscarinic DREADDs. The Ki binding values of Deschloroclozapine to DREADD receptor subtypes hM3Dq and hM4Di were 6.3 and 4.2 nM, respectively.
M11550 3-Aminopropionitrile fumarate 3-amino-propanonitrile (β -amino-propanonitrile (BAPN)) acts as an irreversible inhibitor of lysyl oxidase (LOX), an enzyme involved in collagen cross-linking.
M11549 Palifosfamide Palifosfamide(Isophosphoramide mustard; IPM; Zio-201) is a new DNA alkylation agent and active metabolite of isocyclophosphamide, which has anticancer activity.
M11548 S-Adenosyl-L-methionine disulfate tosylate S-adenosyl-l-methionine disulfate tosylate (Ademetionine disulfate tosylate) is the main biomethyl donor synthesized in all mammalian cells, but is most abundant in liver. Ademetionine has anti-inflammatory activity and has been used in studies of chronic liver disease.
M11547 Ensifentrine Ensifentrine (RPL-554) is an inhaled, pioneering dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50 of 0.4 nM and 1479 nM, respectively. Ensifentrine has bronchoprotective and anti-inflammatory activity and can be used to study chronic obstructive pulmonary disease (COPD).
M11546 CD38 inhibitor 1 CD38 inhibitor 1 (COMPOUND 78c, CD38-in-78C) was an effective INHIBITOR of CD38, with IC50 of 7.3 nM and 1.9 nM for human AND mouse CD38 respectively.
M11545 Dichlorophen Dichlorophen (DDM) is a tapeworm repellent compound. Dichlorophen is an antimicrobial agent that is active against tapeworms, protozoa, fungi and bacteria.
M11544 Enoxolone Enoxolone (Glycyrrhetin) is a β -aromatic resin alcohol pentacyclic triterpenoid derivative obtained by Glycyrrhetin hydrolysis, with anti-ulcer, anti-inflammatory and anti-proliferation properties.
M11543 VPC-70619 Vpc-70619 is a potent oral active n-myC inhibitor. Vpc-70619 inhibits the binding of n-MyC-Max complex to DNA e-box and exhibits strong inhibitory activity against N-MyC-dependent cell lines and high bioavailability for oral and intrabitoneal administration.
M11542 Ochromycinone Ochromycinone ((RAC-STA-21) is a natural antibiotic and a selective inhibitor of STAT3. Ochromycinone can inhibit STAT3 DNA binding activity and STAT3 dimerization. Ochromycinone has anticancer and antibacterial activities.
M11541 JR-AB2-011 Jr-ab2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM. Jr-ab2-011 inhibited mTORC2 activity by blocking the Rictor-MTOR complex (Ki: 0.19 μM). Jr-ab2-011 has anti-glioblastoma multiforme (GBM) activity.
M11540 Propranolol Propranolol is a non-selective β-adrenergic receptor (βAR) antagonist, which has high affinity for β1AR and β2AR with Ki value of 1.8 nM and 0.8 nM, respectively. Propranolol inhibited the binding of [3H]-DHA to rat meninges with an IC50 of 12 nM.
M11539 PCNA-I1 Pcna-i1 is an effective PCNA (proliferating cell nuclear antigen) inhibitor. Pcna-i1 can selectively bind PCNA trimers, and its Kd value ranges from 0.2 μM to 0.4 μM. Pcna-i1 inhibited the growth of tumor cells with an IC50 value of ~0.2 μM.
M11538 MDL-800 Mdl-800 is a selective allosteric activator of SIRT6, a member of the SIRT deacetylase family responsible for deacetylation of histone H3K9Ac and H3K56ac, with tumor suppressive activity
M11537 Nusinersen Nusinersen is an antisense oligonucleotide compound that modifies pre-messenger RNA splicing of the SMN2 gene, thereby promoting full-length SMN protein production.
M11536 Coumarin 2 7-(ethylamino)-4,6-dimethylchromen-2-one
M11535 RG7800 RG7800 is a small molecule SMN2 splicing modifier. RG7800 has the potential to be used in spinal muscular atrophy. RG7800 corrects selective splicing of the human SMN2 gene in the brain of a transgenic SMA model mouse, leading to an increase in SMN protein in the brain.
M11534 Altenuene Altenuene belongs to plant extraction compounds, hydrophilic plant extracts can choose water, methanol, ethanol as solvents, lipophilic plant extracts please choose petroleum ether, benzene and other organic solvents.
M11533 DKK-1 (Mammalian,N-8His) Recombinant Human Dickkopf-related protein 1 is produced by our Mammalian expression system and the target gene encoding Thr32-His266 is expressed with a 8His tag at the N-terminus.
M11532 T7 RNA Polymerase(E. coli) T7 RNA polymerase is a DNA-dependent RNA polymerase that specifically recognizes the T7 promoter sequence (5' -TaatacgactCactatagggaga-3 ') and has high specificity for the phage T7 promoter sequence. T7 RNA polymerase can catalyze NTP incorporation of single or double stranded DNA template downstream of T7 promoter to synthesize RNA complementary to the downstream DNA template of T7 promoter.
M11531 L-Pyroglutamic acid L-pyroglutamic acid is a left-handed isomer of Pyroglutamic acid. L-pyroglutamic acid is a bioactive enantiomer in human body. It is a metabolite of the glutathione cycle and can be converted to glutamate by 5-hydroxyprolinase.
M11530 Guvacine Guvacine, an alkaloid found in areca nut, is an effective inhibitor of GABA uptake. Guvacine inhibited rat GAT-1 with IC50 values of 39 μM, 58 μM and 378 μM, respectively.
M11529 Temuterkib Temuterkib (LY3214996) is a selective, novel erK1/2 inhibitor with an IC50 of 5 nM against ERK1 and ERK2. It can effectively inhibit intracellular P-RSK1 in cancer cell lines with BRAF and RAS mutations. Temuterkib has strong antitumor activity in cancer models with altered MAPK pathways.
M11528 Naringin Naringin, a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.
M11527 BCH001 BCH001 is a quinoline derivative and a selective PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in pluripotent stem cells induced by congenital keratosis (DC). BCH001 did not inhibit poly (A) -specific ribonucase (PARN) or several other polynucleotide polymerases. PAPD5 is A nonnormalized Poly (A) polymerase with an unconventional RNA binding motif.
M11526 Cycloastragenol Cycloastragenol (Astramembrangenin) is the active form of Astragaloside IV and has antioxidant, anti-inflammatory, anti-aging, anti-apoptotic and cardiovascular protective effects. Cycloastragenol is an effective telomerase activator that lengthens telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties.
M11525 2'-Deoxy-5-formylcytidine 2' -deoxy-5-formylcytidine is an effective internal triplet photosensitizer in DNA. 2' -deoxy-5-formylcytidine can be used as a new hot spot for DNA photodamage.
M11524 TMRM Tetramethylrhodamine methyl ester (TMRM) is a cell permeable, cationic fluorescent dye with a maximum excitation/emission wavelength of 550nm/576nm. It emits red fluorescence and can easily adsorb active mitochondria. Store in refrigerator (-5 to -30°C) away from light.
M11523 Rhodamine 6G Rhodamine 6G (Rhodamine 6G) is a fluorescent tracer that can bind to mitochondria, with a maximum excitation/emission wavelength of 525nm/550nm. It emits orange-red fluorescence and should be stored away from light.
M11522 Rhodamine 123 Rhodamine 123 is a membrane-permeable cationic green fluorescent dye that can be easily absorbed by active mitochondria without cytotoxicity. The maximum excitation/emission wavelength is 508nm/530nm, giving green fluorescence for observation of mitochondria, stored in refrigerators (-5 to -30°C) and protected from light.
M11521 DiOC6(3) iodide DiOC6(3)(iodide 3,3' -dihexyl carbonyl cyanine) is a carbonyl cyanine dye that can be used to detect changes in mitochondrial membrane potential. The maximum excitation/emission wavelength is 484nm/500nm. It can be used to look at cell membranes, lipids. Store at room temperature away from light.
M11520 Acridine Orange 10-Nonyl Bromide Acridine Orange 10-nonyl Bromide is a fluorescent probe binding to cardiolipin in mitochondria. The ranging wavelength is 495 nm/521nm. Storage at room temperature and away from light.
M11519 IMT1 IMT1 is the first, specific and non-competitive inhibitor of human mitochondrial RNA polymerase (POLRMT). IMT1 induces conformational changes in POLRMT that block substrate binding and transcription in a dose-dependent manner in vitro. IMT1 reduced deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in significant depletion of cellular amino acid levels.
M11518 Sulforhodamine B sodium salt Sulforhodamine B is a water-soluble dye with a maximum excitation/emission wavelength of 565 nm/586 nm, emitting orange-red fluorescence. It is often used to observe the cytoplasm. Store at room temperature away from light.
M11517 TMA-DPH Tma-dph contains a cationic trimethylammonium substitute that can be used as a surface anchor locator to improve the localization of the fluorescent probe DPH in the membrane. The maximum excitation/emission wavelength is 355nm/430nm, and it is blue fluorescent and stored at room temperature away from light. *The compound is unstable in solutions, freshly prepared is recommended
M11516 Vimseltinib Vimseltinib (DCC-3014) is a C-FMS (CSF-IR) and C-KIT inhibitor with IC50 values of <0.01 μM and 0.1-1 μM, respectively.
M11515 Hoechst 34580 Hoechst 34580 (HOE 34580) is related to important small furrow binding dsDNA selective dyes Hoechst 33258 and Hoechst 33342, with a maximum excitation/emission wavelength of 392nm/440 nm (after binding to DNA), emitting blue fluorescence. For observation of nuclei, nucleic acids, stored at -25°C, away from light.
M11514 Hoechst 33258 Hoechst 33258 tehydrate (dibiphenimide) can bind dsDNA, with a maximum excitation/emission wavelength of 352 nm/461 nm (after binding with DNA), giving blue fluorescence, which is often used to observe the nucleus and nucleic acid. Store at room temperature away from light.
M11513 Ammonium formate Ammonium Ammonium Formate is the Ammonium form of formic acid, which is widely used in a variety of organic reactions. Formic acid is an intermediate product of normal metabolism.
M11512 CBL0137 hydrochloride CBL0137 hydrochloride is an inhibitor of FACT, the histone molecule chaperone. FACT promotes the formation of chromatin transcription complexes. CBL0137 hydrochlorideye also activated p53 and inhibited NF-κB, with EC50 values of 0.37 and 0.47 μM, respectively.
M11511 Vemircopan Vemircopan (ALXN2050) is an oral active complement factor D (FD) inhibitor.
M11510 DL-Propargylglycine Dl-proparyngine (PAG) is an irreversible inhibitor of cysteine γ -lyase (GCL), a key enzyme involved in glutathione synthesis, regulation of homocysteine concentration and metabolism to sulfur pathway that mediates cysteine synthesis.
M11509 DTNB DTNB (Ellman's Reagent) is a chemical used for quantifying the amount or concentration of sulfhydryl groups. It is often used to detect free sulfhydryl groups. DTNB is also an allosteric inhibitor of dengue virus protease (NS2B-NS3Pro) and Streptomyces protease.
M11508 Isoginkgetin Isoginkgetin is a naturally occurring diflavone with antitumor activity. Isoginkgetin directly inhibits chymotrypsin-like, trypsin-like, and caspase - like activities of the 20S proteasome. Isoginkgetin is an inhibitor of MMP-9 and also an inhibitor of pre-mrna Splicing.
M11507 Taurolithocholic acid sodium salt Taurolithocholic acid sodium salt is an effective bile suppressor and Ca2+ agonist.
M11506 Ovalbumin (323-339) (chicken, japanese quail) OVA Peptide (323-339) is an MHC Class II (H-2B) restricted OVA Peptide epitope that binds to the L-A (D) region of Class II MHC protein. It is widely used to study the natural properties of Class II MHC peptide binding and the mechanism of T cell activation. It is also commonly used to study immune allergic reactions, including asthma and food allergies.

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