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AMPK Adenosine Monophosphate Activated Protein Kinase

Inhibitors

Cat.No.  Name Information
M3132 WZ4003 WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively, without significant inhibition on 139 other kinases.
M2238 Dorsomorphin (Compound C) dihydrochloride Dorsomorphin (BML-275) dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM) and bone morphogenic protein (BMP) signaling.
M3946 BML-275 BML-275 (Dorsomorphin) is a cell-permeable pyrazolopyrimidine compound shown to be an AMPK inhibitor with Ki of 109 nM in cell-free assays.
M11462 IMM-H007 Imm-h007 is an adenosine derivative that is an activator of the AMP-Activated Protein Kinase (AMPK).
M11324 BC1618 BC1618, an orally active Fbxo48 inhibitor, stimulates Ampk signaling (preventing activated pAmpkα from being degraded by fBXO48-mediated proteasome). BC1618 promotes mitochondrial division, autophagy and insulin sensitivity in the liver.
M11007 O-304 O-304 is a pioneering, orally active pan-AMPK activator that increases AMPK activity by inhibiting dephosphorylation of pAMPK.
M9911 IM156 IM156, a metformin derivative, is an oxidative phosphorylation inhibitor that increases AMPK phosphorylation.
M9764 MK-3903 MK-3903 is a potent and selective AMPK activator (EC50 = 8 nM).
M8095 PF-06409577 Pf-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 subtype with an EC50 value of 7 nM.
M5336 Phenformin HCl Phenformin HCl is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. It activates AMPK, increasing activity and phosphorylation.
M5326 HTH-01-015 HTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2.
M5207 Bempedoic acid (ETC-1002) Bempedoic acid (ETC-1002) is a novel, first-in-class, orally available ATP-citrate lyase (ACL) inhibitor, Bempedoic acid (ETC-1002) can activate AMPK.
M4897 AICAR AICAR is an activator of AMP-activated protein kinase (AMPK), down-regulates the insulin receptor expression in HepG2 cells.
M4575 Vaccarin Vaccarin is an active flavonoid glycoside with a variety of biological functions. Vaccarin significantly promoted wound healing and proliferation of endothelial and fibroblast cells at the wound site. Vaccarin improves insulin resistance and steatosis by activating the AMPK signaling pathway.
M4483 Platycodin-D Platycodin D, a saponin isolated from orange stem, is an activator of AMPKα and has anti-obesity activity.
M4449 Cimigenol-3-O-α-L-arabinoside Cimiracemoside C, the active ingredient in cohosh, activates AMPK and has anti-diabetes potential.
M4256 Gomisin-J Gomisin J isa small molecular weight lignan found in Schisandra chinensis with vasodilatory activity. Gomisin J regulates lipogenesis, lipolytic enzyme and inflammatory molecule expression to inhibit lipid accumulation by activating AMPK, LKB1 and Ca2+/ Calmodulin-dependent protein kinase II and inhibiting Fetuin-A in HepG2 cells. Gomisin J has potential benefits in the study of non-alcoholic fatty liver disease.
M4233 Ginkgolide C Ginkgolide C is a flavone isolated from Ginkgo biloba leaves, possessing multiple biological functions, such as decreasing platelet aggregation and ameliorating Alzheimer disease.
M4121 6-gingerol [6]-Gingerol is an active substance isolated from ginger and has a variety of biological activities, including anti-cancer, anti-inflammatory and antioxidant.
M3946 BML-275 BML-275 (Dorsomorphin) is a cell-permeable pyrazolopyrimidine compound shown to be an AMPK inhibitor with Ki of 109 nM in cell-free assays.
M3444 A-769662 A-769662 is a potent, reversible AMPK activator with EC50of 0.8 μM, little effect on GPPase/FBPase activity.
M3244 Metformin Metformin (1, 1-dimethylbiguanide) inhibits mitochondrial respiratory chains in the liver, leads to AMPK activation and enhances insulin sensitivity, and can be used in type 2 diabetes research. Metformin can cross the blood-brain barrier and induce autophagy, and Metformin is a CD47 inhibitor in vitro.
M3132 WZ4003 WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively, without significant inhibition on 139 other kinases.



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