| Cat.No. | Name | Information |
|---|---|---|
| M3132 | WZ4003 | WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively, without significant inhibition on 139 other kinases. |
| M2238 | Dorsomorphin (Compound C) dihydrochloride | Dorsomorphin (BML-275) dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK), with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride induces autophagy. |
| M3946 | BML-275 | BML-275 (Dorsomorphin) is a cell-permeable pyrazolopyrimidine compound shown to be an AMPK inhibitor with Ki of 109 nM in cell-free assays. |
| M4897 | AICAR | AICAR is an adenosine analog and activator of AMPK that regulates glucose and lipid metabolism and inhibits the production of pro-inflammatory cytokines and iNOS. In addition, AICAR is an inhibitor of autophagy, YAP and mitophagy. |
| M8095 | PF-06409577 | Pf-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 subtype with an EC50 value of 7 nM. |
| M3244 | Metformin | Metformin (1, 1-dimethylbiguanide) inhibits mitochondrial respiratory chains in the liver, leads to AMPK activation and enhances insulin sensitivity, and can be used in type 2 diabetes research. Metformin can cross the blood-brain barrier and induce autophagy, and Metformin is a CD47 inhibitor in vitro. |
| M5336 | Phenformin HCl | Phenformin HCl is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. It activates AMPK, increasing activity and phosphorylation. |
| M5326 | HTH-01-015 | HTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2. |
| M5207 | Bempedoic acid (ETC-1002) | Bempedoic acid (ETC-1002) is a novel, first-in-class, orally available ATP-citrate lyase (ACL) inhibitor, Bempedoic acid (ETC-1002) can activate AMPK. |
| M4575 | Vaccarin | Vaccarin is an active flavonoid glycoside with a variety of biological functions. Vaccarin significantly promoted wound healing and proliferation of endothelial and fibroblast cells at the wound site. Vaccarin improves insulin resistance and steatosis by activating the AMPK signaling pathway. |
| M4483 | Platycodin-D | Platycodin D, a saponin isolated from orange stem, is an activator of AMPKα and has anti-obesity activity. |
| M4449 | Cimigenol-3-O-α-L-arabinoside | Cimiracemoside C, the active ingredient in cohosh, activates AMPK and has anti-diabetes potential. |
| M4256 | Gomisin-J | Gomisin J isa small molecular weight lignan found in Schisandra chinensis with vasodilatory activity. Gomisin J regulates lipogenesis, lipolytic enzyme and inflammatory molecule expression to inhibit lipid accumulation by activating AMPK, LKB1 and Ca2+/ Calmodulin-dependent protein kinase II and inhibiting Fetuin-A in HepG2 cells. Gomisin J has potential benefits in the study of non-alcoholic fatty liver disease. |
| M4233 | Ginkgolide C | Ginkgolide C is a flavone isolated from Ginkgo biloba leaves, possessing multiple biological functions, such as decreasing platelet aggregation and ameliorating Alzheimer disease. |
| M4121 | 6-gingerol | [6]-Gingerol is an active substance isolated from ginger and has a variety of biological activities, including anti-cancer, anti-inflammatory and antioxidant. |
| M3934 | Saikosaponin A | Saikosaponin A is a novel therapeutic agent against that can be used against obesity‑associated inflammation. |
| M3444 | A-769662 | A-769662 is a potent, reversible AMPK activator with EC50of 0.8 μM, little effect on GPPase/FBPase activity. |
| M3244 | Metformin | Metformin (1, 1-dimethylbiguanide) inhibits mitochondrial respiratory chains in the liver, leads to AMPK activation and enhances insulin sensitivity, and can be used in type 2 diabetes research. Metformin can cross the blood-brain barrier and induce autophagy, and Metformin is a CD47 inhibitor in vitro. |
| M3208 | Geniposide | Geniposide is an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis. |
| M2902 | OTSSP167 | OTSSP167 is a highly potent MELK (maternal embryonic leucine zipper kinase) inhibitor with IC50 of 0.41 nM. |
| M53925 | SAMS | SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK). |
| M44927 | Marein | Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. |
| M44923 | Malvidin-3-O-arabinoside chloride | Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy. |
| M41636 | AMPK activator 12 | AMPK activator 12 is a potent AMPK activator and GDF15 inducer. |
| M38948 | Kazinol U | Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation. |
| M38947 | 3α-Hydroxymogrol | 3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle, acts as a potent AMPK activator, and enhances AMPK phosphorylation. |
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