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BAY 87-2243

Cat. No. M4869
BAY 87-2243 Structure
Size Price Availability Quantity
10mM*1mL In DMSO USD 127 In stock
5mg USD 110 In stock
10mg USD 150 In stock
50mg USD 620 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

BAY 87-2243 inhibits cell proliferation via interference with mitochondrial function. In H460 xenograft mouse model, BAY 87-2243 (4 mg/kg p.o.) reduces tumor weight, HIF-1α protein, and HIF-1 target gene expression levels.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 525.53
Formula C26H26F3N7O2
CAS Number 1227158-85-1
Purity >98%
Solubility DMSO <1 mg/mL
Water <1 mg/mL
Storage at -20°C
References

BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I.
Ellinghaus P, et.al. Cancer Med. 2013 Oct;2(5);611-24. PMID: 24403227.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BAY 87-2243 supplier, HIF, inhibitors

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