Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells.Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells.Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 80 mg/mL|
Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells.
Ilangovan R, et al. J Biol Chem. 2003 Aug 15;278(33):30993-9. PMID: 12783893.
Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.
Slee EA, et al. Biochem J. 1996 Apr 1;315 ( Pt 1):21-4. PMID: 8670109.
|Related Caspase Products|
Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM.
Emricasan is a potent irreversible pan-caspase inhibitor.
NQDI-1 is a selective inhibitor of ASK1 with a Ki of 500 nM.
VX-765 is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM.
Betulinic acid is a pentacyclic triterpene which selectively induces apoptosis in tumor cells.It is a inhibitor of HIV-1 with EC50 of 1.4 μM.
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