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Z-VAD-FMK

Cat. No. M3143
Z-VAD-FMK Structure
Size Price Availability Quantity
1mg USD 54  USD60 In stock
5mg USD 144  USD160 In stock
10mg USD 234  USD260 In stock
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Quality Control
Biological Activity

Z-VAD-FMK (10 μM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 μM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 467.49
Formula C22H30FN3O7
CAS Number 187389-52-2
Purity 99.47%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells.
Ilangovan R, et al. J Biol Chem. 2003 Aug 15;278(33):30993-9. PMID: 12783893.

Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.
Slee EA, et al. Biochem J. 1996 Apr 1;315 ( Pt 1):21-4. PMID: 8670109.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Z-VAD-FMK supplier, Caspase, inhibitors

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