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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9065 | Ac-DEVD-CHO | Ac-DEVD-CHO is a specific inhibitor of Caspase-3 with a Ki value of 230 pM. |
| M6237 | CA-074 | CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM. |
| M6233 | Z-YVAD-FMK | Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. |
| M6232 | Z-LEED-FMK | Z-LEED-FMK is caspase-13 inhibitor. |
| M6231 | Z-VAD(OH)-FMK | Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor. |
| M6128 | BOC-D-FMK | Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM. |
| M5612 | Emricasan | Emricasan is a potent irreversible pan-caspase inhibitor. |
| M5215 | NQDI-1 | NQDI-1 is a selective inhibitor of ASK1 with a Ki of 500 nM. |
| M3532 | VX-765 | VX-765 is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM. |
| M3161 | Betulinic acid | Betulinic acid is a pentacyclic triterpene which selectively induces apoptosis in tumor cells.It is a inhibitor of HIV-1 with EC50 of 1.4 μM. |
| M3143 | Z-VAD(OMe)-FMK | Z-VAD(OMe)-FMK is a cell-permeable, irreversible pan-caspase inhibitor which blocks all features of apoptosis. |
| M3138 | Z-LEHD-FMK | Z-LEHD-FMK is a specific, irreversible Caspase-9 inhibitor. |
| M3136 | Z-IETD-FMK | Z-IETD-FMK is a specific Caspase-8 inhibitor. |
| M3134 | Z-DEVD-FMK | Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10. |
| M2972 | Q-VD-OPh | Q-VD-OPh is a potent pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis. |
| M2551 | LY573636 | LY573636 is a novel anticancer agent that induces apoptosis through the intrinsic pathway and has antiangiogenic activity in preclinical models. |
| M2403 | Apoptosis Activator 2 | Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells. |
| M1867 | PAC-1 | PAC-1 is a procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 μM). |
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