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Abmole Inhibitor Catalog 2017

Caspase Caspase

Inhibitors

Cat.No.  Name Information
M5215 NQDI-1 NQDI-1 is a selective inhibitor of ASK1 with a Ki of 500 nM.
M3532 VX-765 VX-765 is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM.
M3161 Betulinic acid Betulinic acid is a pentacyclic triterpene which selectively induces apoptosis in tumor cells.It is a inhibitor of HIV-1 with EC50 of 1.4 μM.
M3143 Z-VAD-FMK Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor which blocks all features of apoptosis.
M3138 Z-LEHD-FMK Z-LEHD-FMK is a specific, irreversible Caspase-9 inhibitor.
M3136 Z-IETD-FMK Z-IETD-FMK is a specific Caspase-8 inhibitor.
M3134 Z-DEVD-FMK Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.
M2972 Q-VD-OPh Q-VD-OPh is a potent pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis.
M2551 LY573636 LY573636 is a novel anticancer agent that induces apoptosis through the intrinsic pathway and has antiangiogenic activity in preclinical models.
M2403 Apoptosis Activator 2 Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.
M1867 PAC-1 PAC-1 is a procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 μM).


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