Z-Asp-CH2-DCB is an irreversible, cell permeable broad-spectrum caspase inhibitor, with IC50 values of 1.1 and 4.1 μM for caspase-3 and caspase-6 respectively. Z-Asp-CH2-DCB inhibits hypoxia-induced apoptosis.
Z-Asp-CH2-DCB shows anti-ischemic effects in vivo.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO: 10 mM|
Differential effects of caspase inhibitors on TNF-induced necroptosis.
Sawai H. Biochem Biophys Res Commun. 2013 Mar 15;432(3):451-5. PMID: 23410748.
Caspase inhibitors affect the kinetics and dimensions of tracheary elements in xylogenic Zinnia (Zinnia elegans) cell cultures.
Twumasi P, et al. BMC Plant Biol. 2010 Aug 6;10:162. PMID: 20691058.
|Related Caspase Products|
|Caspase-9 Inhibitor III
Caspase-9 Inhibitor III is a potent and irreversible inhibitor of caspase-9.
N-BOC-D-FMK is a Caspase-3 inhibitor.
Ac-DEVD-CHO is a specific inhibitor of Caspase-3 with a Ki value of 230 pM.
CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.
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