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Z-Asp-CH2-DCB

Cat. No. M9293
Z-Asp-CH2-DCB Structure
Size Price Availability
10mg USD 360  USD400 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Z-Asp-CH2-DCB is an irreversible, cell permeable broad-spectrum caspase inhibitor, with IC50 values of 1.1 and 4.1 μM for caspase-3 and caspase-6 respectively. Z-Asp-CH2-DCB inhibits hypoxia-induced apoptosis. 

Z-Asp-CH2-DCB shows anti-ischemic effects in vivo.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 454.26
Formula C20H17Cl2NO7
CAS Number 153088-73-4
Purity >98%
Solubility DMSO: 10 mM
Storage at -20°C
References

Differential effects of caspase inhibitors on TNF-induced necroptosis.
Sawai H. Biochem Biophys Res Commun. 2013 Mar 15;432(3):451-5. PMID: 23410748.

Caspase inhibitors affect the kinetics and dimensions of tracheary elements in xylogenic Zinnia (Zinnia elegans) cell cultures.
Twumasi P, et al. BMC Plant Biol. 2010 Aug 6;10:162. PMID: 20691058.

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  Catalog
Abmole Inhibitor Catalog 2017




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