Free shipping on all orders over $ 500

Caspase-9 Inhibitor III

Cat. No. M10228
Caspase-9 Inhibitor III Structure
Synonym:

AC-LEHD-CMK

Size Price Availability
5mg USD 420  USD420 4-7 Days
10mg USD 720  USD720 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Caspase-9 Inhibitor III is a potent and irreversible inhibitor of caspase-9.

Chemical Information
Molecular Weight 587.02
Formula C24H35ClN6O9
CAS Number 403848-57-7
Solubility (25°C) DMSO 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] M M Mocanu, et al. Br J Pharmacol. Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury

Related Caspase Products
TC11

TC11 is a phenylphthalimide derivative and an activator of caspase-9 and CDK1, as well as a degrader of MCL1.TC11 is structurally related to immunomodulatory active molecules. During prolonged mitotic blockade, TC11 induces MCL1 degradation and leads to apoptotic death.

Ac-Ile-Glu-Thr-Asp-pNA

Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8.

Z-DEVD-AFC

Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore.

Ac-IETD-AFC

Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B.

Z-VDVAD-FMK

Z-VDVAD-FMK is a special inhibitor of caspase-2.

  Catalog
Abmole Inhibitor Catalog




Keywords: Caspase-9 Inhibitor III, AC-LEHD-CMK supplier, Caspase, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.