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Caspase-9 Inhibitor III

Cat. No. M10228
Caspase-9 Inhibitor III Structure
Synonym:

AC-LEHD-CMK

Size Price Availability
5mg USD 378  USD420 4-7 Days
10mg USD 648  USD720 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Caspase-9 Inhibitor III is a potent and irreversible inhibitor of caspase-9.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 587.02
Formula C24H35ClN6O9
CAS Number 403848-57-7
Purity >98%
Solubility DMSO 5 mg/mL
Storage at -20°C
References

Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury
M M Mocanu, et al. Br J Pharmacol. 2000 May;130(2):197-200. PMID: 10807653.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Caspase-9 Inhibitor III, AC-LEHD-CMK supplier, Caspase, inhibitors

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